Tag: "sepsis" at biology news
Study begins to reveal clues to the cause and progression of sepsis
PITTSBURGH, Aug. 13 Not all patients with sepsis
mount the same immune response, even when they loo...e and death. More than 30 percent will die, making sepsis
the 10th leading cause of death. While incidence rates of sepsis
have been steadily increasing over ...
Ethnicity plays a role in neonatal deaths
...rns, but the research team has found that neonatal sepsis
(infection) was the strongest predictor of mortality among African-American infants, even greater than being born at 28 weeks of age or younger. Our results suggest that reducing neonatal infection among African-Americans newborns may help to lowe...
Key to male infertility
...e and inflammatory diseases - such as diabetes and sepsis
- and Al-Abed, an organic chemist by training, ha...once-fatal sepsis. In patients in the throes of sepsis
- an over-reactive and potentially fatal immune response to a bacterial infection - MIF concentratio...
PET/CT use expands: Effectively diagnosing graft infections
...can lead to life-threatening complications such as sepsis
or hemorrhage, with limb amputation and death occurring in more than 50 percent of patients, she indicated. The clinical presentation is often subtle and non-specific. PET is a highly specialized, noninvasive imaging technique that utilizes short-...
Biosite reports on presentation of preliminary data from sepsis program
...ould potentially aid in the assessment for risk of sepsis
progression. Sepsis is an often fatal condition wi...linically useful tool in the assessment of risk of sepsis
progression within 72 hours of patients presenting to the emergency department and meeting the diagn...
Gene chip technology shows potential for identifying life-threatening blood infection
...for halting its lethal spread, doctors who suspect sepsis
typically rush to prescribe powerful antibiotics, ...sts that doctors one day could quickly distinguish sepsis
from widespread non-infectious inflammation based on genetic profiles of patients' blood. Testing th...
New study finds on/off switch for septic shock
...were greatly elevated. A cytokine storm had caused sepsis
in these animals. In summary, auf1 is a protect... results might also help explain why many previous sepsis
drug trials have failed. The cytokine storm needs to be turned off at its source, he says, and auf1...
Scientists identify a septic shock susceptibility gene
...mately, organ failure. One quarter to one half of sepsis
patients die, making it the leading cause of hospital deaths in the US. Dr. Schneider and colleagues demonstrate that the protein encoded by the AUF1 gene destabilizes the mRNA precursors of important pro-inflammatory cytokines. To better understan...
Data show treatment with Remicade reduced hospitalizations for ulcerative colitis patients by half
...f serious infections, including tuberculosis (TB), sepsis
and pneumonia. Some of these infections have been fatal. Tell your doctor if you have had recent or past exposure to people with TB. Your doctor will evaluate you for TB and perform a TB test. If you have latent (inactive) TB, your doctor should begi...
JCI table of contents: October 19, 2006
...only in endothelial cells were more susceptible to sepsis
induced by administration of the bacterial product LPS than normal mice. In addition, tumors grew more rapidly in these mice than in normal mice. This study implicates NF-kappa-B as a regulator of endothelial cells function in health and disease, lea...
New study aims to stop sepsis in its tracks
...c interventions can halt the progression to severe sepsis
and septic shock. Key to the project is determinin...t set of standard procedures to diagnose and treat sepsis
in emergency departments. The National Institute of General Medical Sciences (NIGMS), part of the ...
Acorda announces positive Phase 3 Fampridine-SR study in people with multiple sclerosis
... subject that was observed during an occurrence of sepsis
associated with a urinary tract infection. No deaths occurred during the study. One death was reported for a subject five weeks after the last on-drug study visit. This death occurred outside of the protocol time window for reporting adverse reactio...
JCI table of contents: August 17, 2006
...OLOGY IRAK-M mediates immunosuppression during sepsis
is a life-threatening condition caused, in part, by an initial massive pro-inflammatory response, in...
JCI table of contents: July 27, 2006
...ion, which can cause acute lung injury in cases of sepsis
and infection, is associated with the accumulation in the lung and surrounding blood vessels of fluid, cells, and cellular debris. The deposition of inflammatory exudates spreads rapidly and can soon involve the entire lung or both lungs. The mechani...
New study finds key role for VEGF in onset of sepsis
...infection, but 30 percent of patients with severe sepsis
will die in spite of successful antibiotic therapy...intensive care unit (ICU) hospitalizations, severe sepsis
accounts for 200,000 deaths each year and poses a particular danger in hospital settings, where pati...
Patent awarded for LSUHSC-developed peptide that blocks lethal toxins of anthrax
...timated that about 750,000 American people develop sepsis
each year and that more than 200,000 die from it. ... the factors contributing to the high mortality of sepsis
(which has increased more than 90% in the last 20 years according to the National Vital Statistics R...
Lack of a key enzyme dramatically increases resistance to sepsis
... could be a potentially useful in the treatment of sepsis
and other inflammatory and immune disorders. The ...ese individuals are far more susceptible to severe sepsis
and have a significantly increased risk of dying from it." Sepsis, the body's inflammatory response...
Found in 20 percent of people of African descent: MUHC describes gene that shuts down immune system
...more vulnerable to life-threatening infections and sepsis
('septic shock'). "Only by investigating the mechanisms by which caspase-12 works can we hope to inhibit its destructive effects," says Dr. Saleh. Dr. Saleh and a research team from Merck and the La Jolla Institute for Allergy and Immunology in San D...
First analysis of recent disease outbreak in China
...hen clinicians encounter patients with unexplained sepsis
who have a history of exposure to pigs." They conclude that "the emergence of any new zoonotic disease [an animal disease than can be transmitted to humans] associated with high mortality is of global concern" and call for "international collaboratio...
Researches discover gene critical for protection against septic-shock-induced death
...in regulating the body's innate immune response to sepsis
and septic shock, according to a study by a resear...on as potential targets for the next generation of sepsis
therapies. The incidence of sepsis
in the United States ranges from 400,000 to 750,000 cases per yea...