New study explains process leading to many proteins from one gene
... genome and found that the presence of certain DNA sequences called "tandem repeats" that lie between exons are... be spliced out of the pre-mRNA. The tandem repeat sequences also were complementary and could bind to each other. "The complementary tandem repeat sequences ...Readers of genome decipher signatures of cancer patient outcomes
...of genes is characterized by short, repetitive DNA sequences known as tumor microsatellite regions. Some of these microsatellites are unstable (MSI); others are stable (MSS). Mogens Kruhffer, Ph.D., associate professor, Aarhus University Hospital, Aarhus, Denmark, and colleagues from Denmark and Finland, disco...Scientists track 'stealth' DNA elements in primate evolution
...tionary process in the human genome. Specific DNA sequences that appear to have persisted in a latent state fo...h. Alu elements are short, 300-nucleotide-long DNA sequences capable of copying themselves, mobilizing through an RNA intermediate, and inserting into another lo...Major advance made on DNA structure
...s in determining the structure of all possible DNA sequences a discovery that in one sense takes up where Wats...-dimensional structures of nearly all the possible sequences of a macromolecule, and thereby create a map of DNA structure. As work of this type expands, it shou...Biologists determine genetic blueprint of social amoeba
...ul for other researchers in assembling the genetic sequences of Dictyostelium's genome. Another UCSD biologist involved in the genome effort, Christophe Anjard, an assistant project scientist in Loomis' laboratory, analyzed families of Dictyostelium genes and uncovered relationships with these genes in both an...Shared computing grid cuts data mountains down to size
...dreds of millions of base pairs - long, contiguous sequences of DNA that are the genes' biochemical memory. Suc...sconsin (GLOW), Schwartz can whip through daunting sequences of DNA like nobody's business. "The work we're doing wouldn't be possible without GLOW," says Schwar...For young canaries learning their song, freedom in youth gives way to rules in adulthood
...of their tutors for several months, producing long sequences of dissimilar sounds. Then puberty hit. As the birds' testosterone levels rose, their style of singing started to change. "At sexual maturity, when the song would be important for courting females, rules interfered," says Nottebohm. "The freedom of y...Human cells can 'silence' HIV genes
...sked three questions. First, does HIV have genetic sequences that an HIV-infected cell can detect and transform into the necessary precursors of RNAi, called short interfering RNA (siRNA)? Second, do human cells use siRNAs to disable HIV? Third, if human cells try to battle HIV using RNAi, does HIV have a way ...STN Expreses Version 8.0 gives information professionals advance analysis and security capabilities
...on option Automatic upload of individual gene sequences to DGENE and PCTGEN sequence databases, which makes searching easier Post-processing tools provide flexible cell formatting in tables for better client presentations An ability to export search results for use with the new STN AnaVist TM sof...Founding fathers & mothers: How many crossed the land bridge?
...ting renewed contact. Hey used nine genes in which sequences and frequencies were well documented in the scient... of the new methodology is that it uses actual DNA sequences collected from Asian peoples and Native Americans, an approach that can provide a detailed portrait ...New World founders small in number
...t genes have different histories. Hey analyzed DNA sequences from nine loci, so that the population genetic history could be found despite variation among genes. He also added an additional parameter to standard models to incorporate changes in the size of the ancestral population and of each founder populatio...Study: 'homemade' gene expression technology unreliable
...ds of tiny droplets containing a cell's whole gene sequences that are laid out on a single microscope slide by fast-moving robotic machines. Scientists determine how the expression of individual genes is turned up or down by placing copies of DNA or RNA molecules labeled with fluorescent dyes on the slide, and...Washington State University study points to role of toxins in inherited disease
...ed to the DNA. In epigenetic transmission, the DNA sequences the genes remain the same, but the chemical modifications change the way the genes work. Epigenetic changes have been observed before, but they have not been seen to pass to later generations. While this research focused on the impact of these cha...Pathogens shape evolution of humans' most diverse genes
...t out to test the PDBS hypothesis by analyzing HLA sequences from 61 native human populations worldwide and comparing the degree of HLA diversity to the number of different pathogens known to be present in each population's geographic region. Because other factors, such as a population's migratory history, cou...Public release of pig genomic sequences
...n to the genome survey, 100 libraries of expressed sequences from different pig tissues and developmental stages have been analyzed. These sequences will be released in the near future together with a publication on pig gene expression. This far, th...University of Chicago study overturns conventional theory in evolution
...genes in their study. For each gene, they compared sequences between two mammalian species. This enabled them to measure the mutation rate of the gene specifically, the rate of those mutations that do not affect the protein's structure, called synonymous mutation (Ks). These mutations are functionally neutral...NHGRI selects 13 new targets for large-scale sequencing program
...lves. Consequently, scientists will use the genome sequences of the non-mammalian animals to learn more about how, when and why the genomes of humans and other mammals came to be composed of certain DNA sequences, as well as to gain new insights into the organization of genomes. Sequencing efforts will be car......all but impossible with miRNAs because their short sequences are not as distinctive and thus "cross-hybridize" ...nvolves attaching to color-coded plastic beads DNA sequences complementary to the individual miRNAs whose levels they wish to probe. The beads can be made in 100...Rodent social behavior encoded in junk DNA
...ere a gene turns on. The length of these repeating sequences once dismissed as mere junk DNA in the gene that...icularly intrigued with microsatellites, repeating sequences of letters in the genetic code peppered throughout these regulatory areas of the vasopressin recepto......rogram for screening hundreds of thousands of gene sequences and making them accessible to medical researchers around the world. It has already led to a number of breakthroughs at ANU in one of the largest health problems in the community - dysfunction of the immune system. Autoimmune diseases include type 1 d...