New data demonstrate that Benicar and Benicar HCT significantly reduces systolic hypertension
...n. BENICAR HCT is not recommended in patients with severe renal impairment and is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs. No initial dosage adjustments are necessary with BENICAR in elderly, in moderate to marked renal impairment (creatinine clearanc...Leprosy microbes lead scientists to immune discovery
...bacterium. They were missing, however, in the more severe leprosy infections, meaning that the monocytes hadn't succeeded in producing those key anti-bacterial fighters. "The logic here is that because their monocytes are unable to produce the [CD1b+] cells that can mobilize T-cells, these people don't resp...JCI table of contents July 1, 2005
...se that begins with mild symptoms and becomes more severe with destruction of the pancreatic islets. In a study appearing online on June 2 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Pere Santamaria and colleagues from the University of Calgary sh...From memory formation during sleep to novel components for physics
... analysis in animals, defects in which can lead to severe mental disability. In so doing, the Collaborative Research Centre is both taking on a very current topic of interest and simultaneously building a bridge between molecular and clinical research. (Spokesperson: Prof. Robert Nitsch, the Free Universit...Results of world's first gene therapy trial for arthritis show approach safe, feasible
... cells as a more recent French trial for X-linked severe combined immunodeficiency (X-SCID) in which three children later developed leukemia, the researchers point out that this is the only similarity between the two trials. The studies were concerned with different genes and with different targets, and in...JCI table of contents July 1, 2005
... was largely because most individuals with WS have severe mental retardation, precluding use of demanding tasks and comparison to matched normal controls. In a study appearing online on June 9 in advance of the print publication of the July 1 print issue of the Journal of Clinical Investigation, Andreas Mey...Device traps, disables harmful bacteria
... gram-negative bacterial cell walls that can cause severe inflammatory responses -- with and without the air filters operating under similar conditions. They compared the performance of the filters twice, one year apart, and found that the filters reduced concentrations of culturable bacteria by 69 and 80 p...Deadly infectious entity of prions discovered
...terious, highly infectious prions, which cause the severe destruction of the brain that characterizes "mad cow disease" and several human brain degenerative disorders, can be rendered harmless in the laboratory by a slight alternation of the three-dimensional conformation or shape of the prion protein's str...Gene variant linked to chronic kidney disease
...al exams every 3 years from 1987 to 1999. None had severe renal disease when they entered the study and 1,060 developed some kidney disease, as indicated by laboratory testing, hospitalization or death certificates, by 2003. Most recent estimates indicate that approximately 400,000 US residents undergo dial...Two Children's Hospital Boston researchers win top presidential awards
...ia as a model for understanding how nutrition and severe malnutrition affect bone health in other pediatric settings such as vitamin D deficiency, cystic fibrosis, and chronic steroid treatment for rheumatologic or inflammatory bowel disease. "I'm thrilled that pediatric osteoporosis has been recognized,"...Parasite whips up ideas for bowel cancer treatments
...ymptoms resembling amoebic dysentery. In children, severe trichuriasis can be more serious, leading to anaemia, growth stunting and developmental problems. It may also influence the effectiveness of vaccines against diseases such as tuberculosis and how we cope with other infections such as malaria. "Nemato...Fragment of yellow fever virus may hold key to safer vaccine
...s improve the existing vaccine, which has rare but severe side effects, said Jan ter Meulen, an HHMI international research scholar and associate professor of virology at Leiden University Medical Center in The Netherlands. The group has identified a specific region on one of the viral proteins that elicit...Emerging diseases require a global solution
...s that afflict people, livestock and wildlife have severe economic and social consequences for all regions of the world," said Dr. Bob Cook. "Failing to implement a cross-species, planet wide approach to these emerging health issues will cost more than we can afford. The 'One Health' paradigm can serve as a...Gene mutation responsible for lung and diaphragm defects
...ne mutation who died on the first day of life with severe breathing difficulties, small lungs, and an abnormal diaphragm. "This is the first identified cause of [this type of] diaphragmatic defect," Ackerman said. "And now we have a mouse model to try to learn more." This discovery means that researche...Deconstructing the genome of a notorious yeast
...re often just a minor inconvenience, but in 30% of severe cases, they can lead to death. Candida albicans , the species that causes superficial cases of thrush and vaginitis, is responsible for many of these deaths. Most susceptible are premature infants, people with HIV, cancer patients, and organ trans...Millennium Ecosystem Assessment: Many of 2 billion dryland dwellers at risk as land degrades
...se droughts triple the number of people exposed to severe water scarcity at least once in every generation, leading to major food and health crises....Tips from the Journals of the American Society for Microbiology
...serin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. Journal of Virology, 79. 11: 7095-7103.) One Vaccine May Protect Against Both Parainfluenza and Influenza Viruses Researchers from Wisconsin and Japan have dev...SEROQUEL: An effective treatment option for aggression in patients with schizophrenia
...ant problem in patients with schizophrenia and has severe negative consequences for the patient, families, c...r treating aggressive or violent patients, however severe side effects limit their benefit. 1 Therefore, research in this field, particularly as regards the...Alzheimer's disease linked to inflammation
...fe, as represented bychronic gum disease, may have severe consequences later. Gatz was inspired to focus on inflammation by the work of USCgerontologists Caleb Finch and Eileen Crimmins, who published apaper in the journal Science linking today's record life spans tolower rates of childhood infectious disea...Recurrent miscarriages: Could prednisolone reduce the occurrence of this distressing condition?
...of women with RM. They recruited 110 women who had severe RM (an average of six miscarriages, with a range from three to 22), with no known cause and with regular 28-day menstrual cycles. They took endometrial samples and tested them to identify the quantity of uNK cells. Any women whose endometrial cells c...