Key regulator of bone cells linked to osteoporosis
...are well maintained. Mice that lack IRAK-M develop severe osteoporosis." The study was done with male mice, and possible association between sex hormones and the expression of IRAK-M remain to be investigated, according to Vignery. "For now, IRAK-M looks like an exciting new target for treating or preventin...National Academies news: Spent nuclear fuel storage
...orist attack scenarios that could have potentially severe consequences if carried out successfully, we also identified two relatively simple measures that could be implemented immediately at vulnerable plants to greatly reduce the risks." The committee found that an attack which partially or completely drai...Human chromosomes 2, 4 include gene deserts, signs of chimp chromosome merger
... Wolf-Hirschhorn syndrome, a condition that causes severe birth defects and mental retardation. Human chromosome 2, the second largest human chromosome, originated during the evolution of Homo sapiens by the merger of two chimpanzee chromosomes recently renamed chimp chromosomes 2a and 2b. Other scientists...Liverpool vet creates pain relief diet for arthritic dogs
...ft untreated, the debilitating condition can cause severe pain and lameness. Dog owners are sometimes unable to detect signs of OA in their animals, but it is the most common cause of chronic pain in dogs, affecting one in five over the age of one. Signs of OA in dogs include limping, stiffness, decrease...Mental retardation cause may include cell miscommunication
...e blood builds to toxic levels, ultimately causing severe brain disorders, including mental retardation and seizures. Researchers have been less clear on precisely how that torrent of phenylalanine interferes with brain function. "Despite tremendous progress in the understanding of the molecular basis of P...Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award
...eurological illness causing involuntary movements, severe emotional disturbance and cognitive decline. While it usually strikes in mid-life, it can also attack children and the elderly. There is no treatment to halt its progression, which leads to death after 10 to 25 years. In the United States, the preval...The Academy of Natural Sciences investigates effects of climate change on Delaware tidal marshes
...vironments. A rise in sea level is one of the most severe threats to coastal environments such as the Delaware. Current estimates indicate that as the sea rises, saltwater will move upstream by between 6 and 12 miles. Vile and Velinsky will study the potential consequences of this increased salinity on tida...Nitrite says NO to ischemia/reperfusion injury
...nous protective mechanism that protects cells from severe stress....JCI table of contents May 1, 2005
...nous protective mechanism that protects cells from severe stress. TITLE: Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver AUTHOR CONTACT: David Lefer LSU Health Sciences Center, Shreveport, LA USA Phone: 318-675-6974; Fax: 318-675-4217; E-mail: dlefer@lsuhsc.edu ...Scientists propose new method for studying ion channel kinetics
...ty ion channels in humans have been shown to cause severe diseases like cystic fibrosis and diabetes and more subtle, but still dangerous physiological effects, like over-responses to general anesthetics. According to Bruno, "we found a new way of simplifying the models that reflects the fact that one's kno...Method shows how precisely gene expression signals are copied in DNA replication
... impairments, from slight learning disabilities to severe cognitive disorders. Fragile X is caused by abnormal methylation of a gene called FMR1, Miner said, and other conditions have similar causes. "Methylation is a normal biological process that, in the case of fragile X, is happening at the wrong place...Readers of genome decipher signatures of cancer patient outcomes
... higher risk for metastatic complications and more severe cancer illness as the disease progresses," said Glinsky. "Those people are genetically less likely to respond to the conventional therapies that work for many other patients." Early identification of patients who carry in their chromosomes 'the Deat...UCLA researchers discover new method to generate human bone
...side effects at a lower cost," Ting said. "In more severe cases, such as in children born with congenital an...e is that aside from the pain, which often becomes severe and persistent, there is a high risk of infection. This adds higher risk to the surgery," said Dr. J...Faulty body clock leads to obesity and diabetes
...bined effect of diet plus mutation led to the most severe alteration in body weight and changes in metabolism. The obese mice showed metabolic abnormalities in insulin secretion and the ability of the liver to handle sugar. Obesity is associated with metabolic and cardiovascular disorders often referred t...Brain scans reveal how gene may boost schizophrenia risk
... these two common gene variants. Schizophrenia, a severe mental illness marked by hallucinations and delusions, affects one percent of the population and is treated with antipsychotic drugs that block dopamine. The prefrontal cortex is critical for motivation, learning in response to reward, and working me...Buying time through 'hibernation on demand'
...duced metabolic hibernation could include treating severe blood-loss injury, hypothermia, malignant fever, c...umans could involve treating people suffering from severe fevers of unknown origin. Currently, when a person comes to an ER with such a fever they run the ris...Live faster, die younger: The shortest-living vertebrate
...ortality rates of 2%8% were common, indicating the severe biological time constraints and intense selective pressure that this community experiences. These findings on the shortest-living vertebrate, along with recent discoveries on coral reefs of the smallest and earliest-maturing vertebrate species, are h...'Dead zone' area in Gulf could be increasing, researchers say
... That could mean the dead zone area could be more severe in 2005 and perhaps cover an even larger area than in previous years, says Steve DiMarco, associate professor in the Department of Oceanography at Texas A&M and leader of the project. "During January and February of this year, the flow of the Missis...Natural glucose byproduct may prevent brain damage and cognitive impairment after diabetic coma
...normally low blood glucose is called hypoglycemia; severe hypoglycemia can cause coma. "It's estimated that ... least one episode of diabetic coma resulting from severe hypoglycemia," says Swanson, chief of the Neurology and Rehabilitation Service at SFVAMC and profess...Respiratory syncytial virus poses a significant threat to elderly
... are similar to the common cold, but they are more severe and last longer. The virus is highly contagious, entering the nose or eyes by hands and by direct contact with residue from coughs or sneezes. Falsey and the research group conducted the study through four consecutive winters from late 1999 to early ...