Weill Cornell team identifies potential new cancer drug target
...alled the NF-kappa B pathway causes tumor cells to sidestep apoptosis and become dangerously immortal. "So, drug development aimed at short-circuiting NF-kappa B has become very hot in the past few years," Dr. Wu says. Her team focused on a particular protein involved in the NF-kappa B pathway called the...New chemistry approach promises less expensive drugs
...nceton University chemists may have found a way to sidestep many of the expensive and hazardous barriers that stand in the way of drug development. The new approach allows scientists to synthesize molecules without employing toxic catalysts, and it also does not generate alternate versions of drug molecule...Scientists develop method to find genetic basis for plant variation
...ormation from a large genetic database in order to sidestep the lengthy processes previously used to identify similar genetic variations. Salt employed his methodology to identify a sodium-regulating gene in the extensively studied Arabidopsis thaliana, a wild mustard plant. Salt said this approach could a...Research milestone brings goal closer of cheap antimalarial drug for developing world
...much of the drug synthesis as possible in order to sidestep the expensive laboratory synthesis needed to make artemisinin. That synthesis would have increased the drug's cost beyond the researchers' ambitious target of 25 cents per dose. They now have nearly achieved that goal by engineering the production of...Stem cells from brain transformed to produce insulin at Stanford
...ght that human neural stem cells may be one way to sidestep the more problematic embryonic stem cells. The study shows that his intuition was correct. "When you look at islets cells you realize that they resemble neurons," Kim said. Like neurons, islet cells respond to external signals by changing their elect...Purdue scientists hunt for 'secret X' to treat liver cancer
... and liver cancer may one day help cancer patients sidestep the poison of chemotherapy, a Purdue University study suggests. The research group of Ourania M. Andrisani (oo-RAHN-ee-ah an-dri-SAH-nee) has shown that a protein the hepatitis virus instructs chronically infected liver cells to produce - known as th......sts, making it possible for errant parasite DNA to sidestep several obstacles on its way into a host cell....