Epigenetic drugs, promising for breast cancer treatment
...gulatory factors, NM23, negative regulators of Wnt signalling and Major Histocompatibility Complex Class-I and II genes. In addition, these drugs down-regulate genes such as ABCB5, a recently identified member of the ABC transporter family implicated in multidrug resistance, which is predominantly expressed by ...Finding a cure for cancer: The holy grail of science
...y of Vienna has demonstrated. He is looking at two signalling pathways which are regulated by stress or interferon and related to immune response. Although both pathways can be activated by independent stimuli, an immune response is only obtained when both pathways are acting on the gene at the same time. This ...U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
...birds to see how they activate downstream cellular signalling pathways. To do this, they are using reverse genetics technology, where researchers begin with a gene and figure out its function. These studies will allow the team to identify the genes that enable the virus to cause disease, laying the groundwork...Enzyme inhibitor produces stable disease in patients with advanced solid cell cancers
...lays an important role in the Ras/Raf/MEK/ERK cell signalling pathway, which regulates cell proliferation and su... associated with a profound inhibition of the cell signalling protein pERK and a reduction in cell proliferation which indicates that the drug is working against...Scientists discover way to block growth of prostate cancer cells
...dicals, which are known to play a key role in cell signalling and prostate cancer development. "These results demonstrate that polyamine oxidation is one of the major causes of androgen-induced oxidative stress in prostate cancer cells," said Dr Basu. "The discovery of this pathway is a major step forward in...Europe's best young group leaders win EMBO support
...Brussels Johanna Ivaska (FI)Integrin traffic and signalling in cancerTurku Centre for Biotechnology Bruno Klaholz (FR)Complexes in gene expressionInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Strasbourg Jean-Christophe Marine (BE)Key modifiers of p53Flanders Interuniversity Institute f...... strength. A crucial player in this process is the signalling molecule NF-kB. It is well known as a messenger of inflammation and has recently been implicated in other degenerative conditions such as multiple sclerosis. The groups of Nadia Rosenthal and Manolis Pasparakis at the EMBL Mouse Biology Unit have now...Scientists' cell discovery unearths evolutionary clues
...ree allows us to reconstruct the evolution of the signalling mechanisms that generate multicellularity. It also provides a powerful tool to identify core ancestral processes that regulate the most basic aspects of development." Professor Baldauf, of the Department of Biology at York, said: "We have investiga...Resistance and genetic sensitivity to sleeping sickness
...eractions, by means of identifying genetic markers signalling risk. That should open the way in the long term to possible development of innovative control strategies against sleeping sickness....Inheriting a tendency to brain infection
... blood cells failed to produce an important immune signalling molecule, type I interferon, when challenged with the virus in a laboratory flask. At about the same time, Bruce Beutler of the Scripps Research Institute in La Jolla, California created a mutant mouse that did not respond to certain molecules that...New target for cancer therapy identified
...onash University scientists investigating the cell signalling pathways that turn on a gene involved in cancer de...ting breast cancer cells to identify the molecular signalling that is required to turn on, and also inhibit, the gene that produces telomerase. They have found tw...After insects attack, plants bunker sugars for later regrowth
...kinase activator (GAL83) in the plant tissue via a signalling cascade that remains unknown. GAL83 is not unknown in the animal kingdom and in microorganisms: it is the beta-subunit of a protein complex (SNF1 related kinases), which regulates the use of glucose or galactose in mammals and yeast - especially duri...Molecular motor helps cells tell which way is up
...knew that a lipid called PIP3 is very important in signalling polarity. But the process everyone wanted to understand, he said, "was the trafficking and disposition of this lipid to where it was needed at the growing tips of the cells." Chishti's research team, including Kaori Horiguchi and Dr. ToshihikoHanada...Germans do well in the third round of EURYI Awards
...mpal neurons in adults. Lie will investigate which signalling pathways regulate these stem cells. He hopes not only to provide a better explanation of the molecular mechanisms, but also to indicate possible strategies for the maintenance of hippocampal functioning in older people. Dr. Frank Keppler (38), Nat...Eleven million Euros for Endotrack
... unexplored connection between endocytosis and the signalling of growth factors into the cells and understanding...eus where it regulates gene expression. Overall, signalling from growth factors is a highly specific and fine-tuned process. Up until now little has been known ...AACR awards $2.6 million in grants for metastatic colon cancer research
...ill affect choice of therapy and will show whether signalling abnormalities can be reversed using immunotherapy. Douglas V. Faller, M.D., Ph.D., Boston University School of Medicine, "PKC-Delta as a Therapeutic Target in Colon Cancer." The approach is to inhibit PKC-delta which is not critical for normal ...First human trial of antibacterial contact lens
... and disrupts microbial infection by "jamming" the signalling systems bacteria rely on to form biofilms. Because the technology does not kill bacteria, Biosignal's technology is less likely to create the drug-resistance problems that plague current anti-microbial treatments. The US Centers for Disease Control e...Tumour development actors ERK1 and ERK2 found to play opposite roles
... ERK2. ERK1 and ERK2 are crucial components of the signalling cascade that mediates the function of the Ras onco...ition to bind to other regulatory molecules in the signalling pathway. Their activities and expression levels must be finely tuned to ensure normal cell prolifera...How IVF could be causing genetic errors in embryos
...bsequent poor growth). Gnas plays a role in cell signalling and is associated with McCune-Albright syndrome (involves bone, hormone and skin abnormalities), pseudohypoparathyroidism Ib (involves inadequate levels of calcium and excessive levels of phosphates in the blood), and GH-secreting adenomas (type of t......s that the butterflies are toxic. The wing pattern signalling system is so finely tuned that butterflies with even slight deviations in color pattern -- confusing signals-- suffer from higher predation. Non-toxic butterfly species may copy common wing patterns from this group in order to take advantage of the p...