A tumour suppressor in mice and men
...The researchers were able to describe the cellular signalling path which causes uncontrolled growth when the Cyld gene is defective. Furthermore, there is evidence that such a defective Cyld gene may be the root cause of kidney, liver, uterus, and large intestine tumours. Cyld could possibly be one of Bcl-3's m...The molecular post office inside the cell
... embedded into the cell's membranes - for example, signalling receptors. One particular molecular complex is important in protein sorting. It is made from an active ribosome - that is, the protein synthesis machine in the cell - called the signal recognition particle (SRP), and its corresponding receptor. It is...Discovery points to more effective ways of regulating cell signalling
...es (growth factors). It is important that cytokine signalling is properly regulated within the human body. If SOCS3 permits cytokine signalling to be too "loud", then the excess of growth signals can cause crippling inflammatory diseases such a...Young researchers recognised for scientific achievements
...robiologist, is investigating the role of the CD95 signalling system in the physiological and pathophysiological processes of the central nervous system. The CD95 signal path controls programmed cell death (apoptosis) of nerve cells. Martin-Villalaba has discovered that blocking this signal path can reduce dama...Diabetes and cancer: Alpha connection
... present work imply that cancer cells hijack a key signalling pathway to fuel their energy needs and drive their proliferation and survival. The current work has far-reaching implications, given that several million of people are affected by metabolic disorders, and every year, several hundreds of thousand new ...Increased environmental carbon levels the good news!
... dangerous human pathogen. So far, AC is the only signalling molecule known to directly respond to inorganic carbon. Dr Martin Cann will present this work at the Society for Experimental Biology Annual Main meeting at the University of Kent, Canterbury on Monday 3rd April [session A1]. Dr Cann's group have b...Plant cells 'black out' when eaten by leafworms
...kers. The researchers investigated two defence and signalling substances in leaves attacked by pathogens: Hydrogen peroxide (H2O2), and calcium ions. The scientists used soybean cell cultures to determine that cellular calcium ion amounts increased with concentration of hydrogen peroxide in the nutrient solutio...Sexual differences in immune response appear at puberty
...between males and females are controlled by a gene signalling pathway called the Fas/FasL pathway, which is modulated by the female sex hormone estrogen....Cancer researchers found a new mechanism potentially explaining evolution of signalling pathways
...ionary change that occurred in a key developmental signalling pathway. The finding suggests a potential mechanism for evolution of complex intercellular signalling pathways. A relatively small number of evolutionary conserved genes are responsible for controlling......l loses a large portion of its synapses. Moreover, signalling at the remaining contact sites is significantly impaired. Staufen proteins are involved in the transport of molecular blueprints (mRNAs) to specific locations in a cell. The disturbance in the structure and function of synapses without Staufen2 prote...Vitamin supplement could help treatment-resistant asthma
...ells of the immune system to synthesise a secreted signalling molecule, called IL-10. This molecule can inhibit the immune responses that cause the symptoms of allergic and asthmatic disease. Unlike T-cells from healthy individuals, or patients that respond to steroids, T-cells taken from patients who are ster...Six Central European scientists awarded EMBO/HHMI startup grants
...ity, Brno, Czech Republic Mart Loog Protein kinase signalling networks in the eukaryotic cell cycle, Institute of Technology, University of Tartu, Tartu, Estonia Richard Stefl Structural studies of protein-RNA complexes involved in RNA quality control, National Centre for Biomolecular Research, Masaryk Universi...Scientists push forward understanding of multiple sclerosis
...lex nervous systems, such as humans, achieve rapid signalling between their nerve cells. Communication between nerve cells and other organs such as muscles needs to be extremely fast, so that the body responds quickly to instructions from the brain. Electrical signals can travel rapidly from the brain because......ternal "communications network" known as the NF-kB signalling pathway. Cells have many such networks; their function is usually to switch genes on or off, changing the chemistry and behavior of the cell. Most drugs work by interfering with molecules that play important roles within these networks. Scientists kn...Researcher finds new use for botox
...tralia's role at the forefront of neurobiology and signalling research." Dr Meunier, whose PhD thesis at Paris University concentrated on nerve cell communication, furthered his interests in the field during postdoctoral studies at Imperial College, London on synaptic research, and on phosphate-containing lipi...Scientists identify two key genes linked to aggressive breast cancers
...ents." Notch1 and Jagged1 are players in the Notch signalling pathway, which is normally involved incell communi...ains of patientswith Alzheimer's disease. As Notch signalling also depends on gamma secretase, these drugsmay be useful in treating Notch-dependant cancers." The ...Discovery that bacterium is phosphate gourmet key clue to what makes it most social of bacteria
...n such a social manner. Dr Whitworth looked at the signalling pathways used by the bacterium to process informat...us has an unprecedented number (around 150) of the signalling pathways known as "two component switches" which dramatically increases the level of complexity of i...Tissue regeneration operates differently than expected
...ously, the stem cells are recruiting the IL-4/NFAT signalling pathway which also is involved in the activation of T-lymphocytes during immune response. From the findings presented by Thomas Braun and his collaborators some important consequences for the use of adult stem cells in possible therapeutic approache......s" at the University of Hamburg is to identify new signalling transduction mechanisms in myocardial cells. The purpose of this is to create a starting point for therapeutic approaches to combat the increasing heart failure rates. Engineering Sciences The Research Unit "Solid Sponges Utilisation of Monolithic...