Unrestrained retina too much of a good thing
...e. The Salk team showed that two chemical cues, or signalling proteins, must be present in the right place at th...cally engineered mouse embryos that lacked the two signalling proteins Vax1 and Vax2. The mice developed normally until approximately 10 days after conception, at...Function of cancer genes discovered
... protein plays an important role in the NF-kappa B signalling route. This is a cellular communications system which becomes overactive if the CYLD protein is mutated. This results in increased cell growth and the occurrence of tumours. An important implication of this research is that inhibition of the NF-kapp...New findings in taste and smell research
...De-orphaning, functional characterization and cAMP signalling of five human V1R-like receptors. Genetic Odorprints May Use Peptides -- Encoding immune system signals by the mammalian nose: The scent of genetic compatibility. Reduced Selection for Human Odor Receptor Genes -- A genomic perspective on the evo...Wnt signalling protein Dishevelled acts in the nucleus, not just in the cytoplasm
... Dishevelled, a key player in the Wnt/beta-catenin signalling pathway, has to be localised in the nucleus to per...nt signals transmitted through the 'canonical' Wnt signalling pathway. Dsh has always been considered to be a cytoplasmic protein, exerting its function as a stab...The Louis-Jeantet-Prize for Medicine 2005
...in finding out what genetic alterations affect the signalling pathways of Rho GTPases, for instance, to modify the regulation of the cytoskeleton and to permit epithelial tumour cells to escape from the primary tumour. With the Louis-Jeantet Prize for medicine, Alan Hall wants to further investigate how the spe...Study in Royal Society journal on first evidence for magnetic field detection in sharks
... instead. Thus, paradoxically, it is not avoidance signalling that stabilises the warning signals, but the actions of predators who are invited to taste the prey. Contact: Dr Gabriella Gamberale Stille, Department of Zoology, Stockholm University, 106 91 Stockholm, SWEDEN Ancient DNA by Dr E Willerslev and Pr...Dream home: Malaria parasite renovates to suit its tastes
... involved in malarial infection and deciphered the signalling code, which is critical for the protein export mechanism. "We have tried removing certain proteins from the parasite gene knockouts, for example and the parasite survived well in most cases. So those proteins were not useful drug targets. But some...New weapon in germ warfare: 'Jamming' bacteria signals stops cholera
...ays Dr McDougald. Many bacteria rely on a signalling system known as quorum sensing to detect when enough of their own kind is present and then change their behaviour and attach themselves to a surface on a host or in the environment. The seaweed, a red algal species found at a UNSW marine r...Human gland probably evolved from gills
... such as muscle contraction, blood coagulation and signalling by nerve cells, require specific levels of calcium in the body. In humans, calcium levels are regulated by the parathyroid gland, which secretes parathyroid hormone if the calcium concentration in the blood falls too low. This hormone then causes the...Nitric oxide is essential for animal development
...ave discovered that nitric oxide (NO), a versatile signalling molecule involved in a diversity of clinically imp...velopment. NO has been the most intensely studied signalling molecule for more than a decade. Produced by NO synthases (NOS), it regulates blood pressure, contri......dest mechanisms used for environmental sensing and signalling in bacteria, and it's critical for successful competition in diverse and frequently changing conditions. As a neutral molecule, glucose is able to pass freely in and out of a bacterium cell's membrane. When glucose is available as the energy source, ...