Acoustics meeting in San Diego
...ppiness has similarities: longer duration, shorter silences between words, and higher pitch. Sadness is disti...emotions with its lower acoustic energy and longer silences between words. Interestingly, they found that the difference between happiness and anger and sadnes...NIEHS to develop new RNAi library to help fight disease
...Ai, or RNA interference, is a new technology which silences specific genes. RNAi technology "turns off" specific genes so scientists can learn more about how the genes influence the cell. Knowing how a gene responds to a stress allows scientists to gain a more comprehensive understanding of how chemicals and...Fox Chase Cancer Center scientists discover key proteins linked to aging and cancer
...SAHF (senescence-associated heterochromatin foci), silences the genes that promote the cells' growth. Adams' discovery reveals the mechanism of SAHF formation.SAHF are domains of densely packed chromatin that repress activity of the genes that normally drive cell proliferation. Adams and coworkers have iden...PNAS highlights for the week of April 4 - 8
...nt with RNA interference (RNAi), which selectively silences particular genes. Biochemical Strategies for Burn Trauma Genomic analysis identifies potential new therapies to improve both short- and long-term care of skeletal muscle trauma in burn patients. Curry Compound Affects Tumor Gene Curcumin, a natur...Gene mutated in cancer found in some with autism
...ent cells from becoming cancerous. When a mutation silences tumor-suppressor genes, it can place a person at higher-than-usual risk of developing cancer during his or her lifetime. Autism is a developmental disorder that typically appears by age 3. It has a prevalence of four to 10 cases per 10,000 people. It...Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration
...ed bacteria to synthesize double-stranded RNA that silences planarian genes. The bacteria effectively become tiny pills-five to 10 microns across-that now can be mixed into planarian food. When Snchez Alvarado and his associates fed the worms dinner, the RNA diffused throughout their bodies. Snchez Alvarado ...Fibromyalgia patients may benefit from cough remedy, UF study finds
...tromethorphan, an over-the-counter medication that silences coughs, may help fibromyalgia patients quiet over-reacting nerves that amplify ordinary touches into agony. A University of Florida study documents, for the first time, that dextromethorphan temporarily reduces the intensity of fibromyalgia "wind-up...Rett gene regulates alternative splicing
...urological disease found mostly in girls, not only silences some genes but in combination with another also regulates alternative splicing, crucial to the formation of proteins -- a finding that may explain the symptoms associated with this puzzling disorder and others related to it, said Baylor College of Me...MicroRNA may have fail-safe role in limb development
...ty in chicken embryos and in mice, finding miR-196 silences a chemical important for transferring information from DNA to RNA within a cell - a transcription factor. "It's turning off a transcription factor in the hindlimb that is important for forelimb development," Harfe said. "But it still doesn't explain ...Interfering RNA silences genes in 'slippery' immune cells
...nes by studying what happens when RNAi temporarily silences them--a process calling "knocking down" the gene. The research by Dr. Finkel's team aims to extend RNAi to a wider pool of researchers by making the technique less expensive and more widely available, as well as adapting it to T cells, a cell type pr...In a technical tour de force, Salk scientists take a global view of the epigenome
...d. The investigators also found that methylation silences transposons, so-called "jumping genes," which can wreak genomic havoc by hopping about the chromosomes. In the words of Ecker, undermethylated transposons "just go wild," suggesting that mother nature keeps transposons in time-out by covering them wi...Bee genome information housed at Texas A&M University
...tion into proteins. RNA interference effectively silences genes by administering short double-stranded RNAs complementary to the gene one wants to turn off, he said. "While RNAi recently won the Nobel Prize for the scientists who discovered it in nematodes--Craig Mello and Andrew Fire--its tremendous pote...Detailed 3-D image catches a key regulator of neural stem cell differentiation in action
...ar and Molecular Medicine at UCSD, found that Scp1 silences neuron-specific genes in non-neuronal cells last year. "Having a specific inhibitor would give us a lot of insight into the development of the fetal nervous system and would allow us to chemically push embryonic stem cells to acquire a neuronal fate ...Drug strategy makes cancer genes get lost in translation
...a result, the molecule, called 4EGI-1, effectively silences oncogenes, which have links to cancer. They also found evidence that the small molecule inhibitor exhibits activity against multiple cancer cell lines, including lung and blood cancer cells. While cancer-promoting proteins may be lost as a result o...Salk scientists hammer out a pathway that promotes muscle cell survival in mice
...scle cells grown in the lab using a technique that silences gene expression. Less SIK1 activity resulted in less phosphorylated HDAC. With the unphosphorylated HDAC brake now firmly in place, expression of muscle-specific target genes was also reduced. Conversely, when the researchers boosted SIK1 levels or i...... Based on what weve learned so far, a therapy that silences the expression of the toxic RNA molecule seems to be a viable treatment for DM. In the Rachel Fund announcement last month, Dr. Brenda Banwell with Muscular Dystrophy Canada (MDC) noted, the work of Dr. Mahadevans laboratory will provide novel insi...