U-M scientists see ubiquitin-modified proteins in living cells
...Kerppola adds, "because proteins must get to their sites of action in order to do their jobs. Each protein must fulfill many different functions in different cells and in response to different stimuli. It is the variety of modifications and interactions with partners that enable the same protein to accompl...Experts present new research on hot topics in aging at GSA's annual meeting in Washington, DC
... a study of 3,075 men and women aged 70-79, at two sites - Pittsburgh and Memphis, with no reported difficulty walking 1/4 mile, walking up 10 steps, or performing ADL, was designed to assess whether risk factors for functional decline were similar in Blacks and Whites of the same age and reported function...'Junk' DNA may be very valuable to embryos
...ut rather appear to be a large repository of start sites for initiating gene expression. Therefore, more than one third of the mouse and human genomes, previously thought to be non-functional, may play some role in the regulation of gene expression and promotion of genetic diversity. Dr. Barbara B. Knowle...Award-winning INEEL probe to help safely monitor hazardous waste sites
...ystem was developed, geoscientists monitored waste sites by drilling around them -- a task as tough as tryi...mission, Jones notes. About 300,000 waste disposal sites are scattered across the nation, some containing PCBs, corrosives, heavy metals, and radioactive mat...NHGRI seeks next generation of sequencing technologies
...esearch and for training and career development at sites nationwide....Study identifies target for preventing sexual transmission of HIV
...mechanism critical for the transmission at vaginal sites of infection, that may offer a simple strategy for...to how the virus actually gets into cells at these sites of transmission, called mucosal sites. HIV can use certain cell surface molecules such as CCR5 to g...Pushing the envelope to overcome HIV drug resistance
...rotease. Also, when the protease mutates at unique sites that contact the inhibitor envelope but not the substrate envelope, drug resistance emerges. This general principle offers a rational basis for combating drug resistance more aggressively by preventing a common mode of escape. Such a tool would be of...Medical geneticists elected to Institute of Medicine
...with organizations sponsoring genetics-related Web sites to ensure they contain high-quality information. Prior to joining NHGRI in 1999, Dr. Guttmacher directed the Vermont Regional Genetics Center at the University of Vermont in Burlington, where he launched a series of public health genetics prog...Dr. Harris receives NIH Javits Neuroscience Investigator Award
... of anatomical changes that occur at synapses, the sites of communication between brain cells. Congress established the Senator Jacob Javits Award in the Neurosciences in 1983 to honor the late New York senator with amyotrophic lateral sclerosis who was an advocate for research of the brain and nervous s...Large-scale forces shape local ocean life, global study shows
... For example, Witman and his team sampled five sites from Maine to Massachusetts and found anywhere fro...phic regions and randomly sampled at a total of 49 sites within these regions, which included the Gulf of Maine, Iceland, the Northeast Pacific, the Galapago...ORNL system eliminates perchlorate, helps scientists trace source
...he system also is being tested at two contaminated sites in California. Gu will present findings from those tests at meetings this month with municipal water utilities and environmental remediation groups in California. The Environmental Protection Agency proposed one part per billion in 2002 as th...OHSU study: Bacterial switching mechanism key to survival
...g them to then bind a large number of specific DNA sites on the bacterial chromosome. Such binding, in turn, redirects the metabolic program of the cell so only proteins that are needed for glucose metabolism are made. When glucose is not present, HPr is not phosphorylated properly for CcpA binding, leadin...Molecule that helps DNA replicate may make good target for cancer therapy
...sizes new DNA strands--be escorted to the specific sites on the DNA strands where it can attach and go to w...he DNA polymerase alpha complex to the chromosomal sites where replication originates. It does this by attaching to the protein that keeps the two DNA strand...Study is looking at ways to help stroke survivors regain lost motor skills
...earch is needed to validate these findings. Other sites in the study were the University of Illinois-Chicago, Rush University Medical Center, University of Arizona, Wayne State University, University of Minnesota and Kansas University. "It is our hope that by stimulating the surface of the brain we...Three years of Proba, the 'smart' satellite that runs itself
...al Infrared Detection). CHRIS has been reacquiring sites of forest fires previously detected by BIRD to identify the extent of the burnt area and identify any vegetation regrowth, in order to study the long-term effects of the blazes. In a related field, CHRIS images have also been acquired on behalf of t...Predicting infection risk of mosquito-borne disease
...tion density peaks, typically either near breeding sites or where human density is highest. The proportion of infectious mosquitoes, on the other hand, reflects the age of the mosquito population: it peaks where older mosquitoes are found--farther from breeding sites--and when populations are declining. Th...Military hazards are greater for Native Americans, according to sociological research
...can lands tend to be located in the same county as sites deemed to be extremely dangerous due to the presen... the contiguous 48 states. The research focused on sites containing unexploded ordnance, including landmines, nerve gases, and toxic and explosive shells, cu...Electronic records to improve care for children with asthma
...he first time, records of patient care at multiple sites will be accessible to clinicians in the emergency department, all primary care settings, hospital inpatient units and specialty care." Research will focus on asthma in children, the most common chronic illness in childhood, which is responsible fo...Are museum collections of ancient life representative?
...time consuming and expensive. Also, many promising sites are being covered with human developments or prese...he efforts of several researchers, provide data on sites no longer available, and make data collection cost and time effective. However, it is important to u...BU chemist to map DNA's surface, uncovering details that will show how structure abets function
...ullius plans to then build maps of protein-binding sites and sequences critical to the folding of chromatin, the nuclear structure that condenses to form chromosomes during DNA replication. DNA bound up as chromatin has a complex structure -- it twists around histone proteins, turns upon itself, and, in g...