Tag: "sodium" at biology news

Botulism bug says no to nitric oxide, provides key to molecule's role in human cell signaling

...how the decades-old practice of treating meat with sodium nitrite prevents life-threatening food poisoning known as botulism. Discovering how botulism-causing Clostridium botulinum detects nitric oxide (NO) sheds light on how NO connects with its receptor protein in humans to govern crucial processes in ...

'Broken' gene reveals evolution of salt retention and possible ties to hypertension

...ssociated with type 2 diabetes." Humans need salt, sodium chloride, to transport nutrients, transmit nerve impulses or contract muscles, such as the beating heart. The average adult contains about 250 grams of salt, enough to fill three small saltshakers. This salt is constantly lost through sweat and uri...

Novel biotoxin being studied for use in opioid withdrawal

...oin withdrawal in China. It works by blocking slow sodium channel nocicipetive pain fibres in a highly selective way. Tetrodotoxin proved to have such good analgesic properties in the initial Chinese trials that it is also now being evaluated for clinical use in the treatment of refractory cancer pain. "Th...

'Blind' cells see the light; maybe someday humans will, too

...t of cells. Spanning the membranes of nerve cells, sodium and potassium channels, in particular, facilitate ...s." One solution, Kramer said, is to re-engineer a sodium channel to function just the opposite of the mutated potassium channel, then target the engineered s...

The Cochrane Library Newsletter, 2005, Issue 1

... studies aimed at evaluating the effects of adding sodium bicarbonate to the blood of people who have ingest... should be a priority, particularly to see whether sodium bicarbonate can help, because this chemical showed promising outcomes in early research, is cheap, w...

Mayo Clinic researchers discover new kind of heart failure gene

... the same gene. SCN5A is the gene that encodes the sodium ion channel in the heart, which helps regulate transport of positively charged sodium ions, and therefore the heart's electrical patterns. Among the individuals with an SCN5A mutation, ...

Paralytic shellfish toxins cause mutation that allows clams to accumulate 100 times more toxin

...ier work that the toxins block the function of the sodium ion channel, a molecular switch that generates the...ll mutation that prevents them from binding to the sodium ion channels in the clam's nerve tissue. Instead of binding to the ion channels and causing paralysi...

Mutation in clams protects against paralytic shellfish poisoning but raises human health risk

...e mutation, which changes a single amino acid in a sodium channel, makes nerves less sensitive to those toxi..., a protein in the nerve cell membrane that allows sodium ions to pass through the membrane. Regulation of sodium is critical to nerve cell function. Without ...

At the molecular level, the predator is the prey

...s is tsNa(V)1.4, a tube-shaped protein that allows sodium ions to flow into the cell. When nerve cells' ability to move sodium in and out is hampered, paralysis and death can result. Tetrodotoxin (TTX), a powerful paralytic poi...

Protein tags regulate key ion channel

... world. Ion channels allow ions such as potassium, sodium and calcium to flow in and out and so are key regulators of many fundamental processes in biology. "Ions are the currency of the cellular world," explained Goldstein. "Cells collect some ions, others they discharge. Ions are stored, spent, and excha...

The promise of new medical uses for sodium nitrite for heart attack and organ damage

.... The scientists found that low concentrations of sodium nitrite had a strong protective effect preventing...the NIH research team that found that infusions of sodium nitrite into the human circulation leads to the production of nitric oxide (NO), a strong blood vess...

Scientists propose new method for studying ion channel kinetics

...dden." John Pearson added, "Ions such as calcium, sodium and potassium play a fundamental role in nearly all biological processes. Calcium, for example, is important in fertilization, cell death, cell division, human hearing, memory, vision, and the immune system. It also plays a factor in cancer, Alzheime...

Newly discovered genetic disease sheds light on body's water balance

...g the diagnosis of NSIAD as an explanation for low sodium levels in their pediatric patients." MEDICAL MYST...oms of fluid overload and strikingly low levels of sodium in their blood. The first child suffered from severe irritability. A few months later, the second in...

Purdue study finds races react differently to dietary salt, calcium

...can-American and Caucasian adolescent girls handle sodium and calcium differently, which may help explain wh...escents, we also confirmed that blacks retain more sodium on a high-salt diet than whites," said Connie Weaver, distinguished professor and head of Purdue's D...

JCI table of contents June 1, 2005

...d to treat hypertension and they work be enhancing sodium excretion by inhibiting a protein in the kidney called NCC. Mutations in the gene that encodes the NCC protein cause a disease called Gitelman's Syndrome, which is characterized by low calcium and magnesium levels and kidney problems. The molecular ...

New data demonstrate that Benicar and Benicar HCT significantly reduces systolic hypertension

...he release of another hormone that causes enhanced sodium and chloride (salt) retention, with a resultant increase in vascular water retention and blood volume that also contributes to an elevation in blood pressure. BENICAR is a member of the ARB class of antihypertensive medications that help lower blood...

PET confirms changes at brain molecular level in bulimia nervosa patients after CB therapy

...lyte imbalances (especially of potassium, calcium, sodium and chloride). In rare cases, it may be fatal. While the cause of bulimia nervosa is still unknown, research shows that certain brain chemicals may function abnormally in bulimia patients. Cognitive-behavioral therapy, which teaches patients how to c...

Oral rinse predictor of marrow transplant effectiveness

...bone marrow transplant patients, testing the basic sodium bicarbonate solutions for the return of neutrophils, specialized white blood cells which fight infection. Their test was able to detect the white blood cells about a week earlier than the blood test which is commonly used to confirm a successful bone...

Viagra shows potential vasopressin-independent cGMP signaling in certain diabetes

...s associated with excretion of abnormal amounts of sodium in the urine. Because the present study was performed over a short time period, only a small effect on final urine concentration was found. Long-term studies need to now be carried out, and combination therapy as well as maintenance of subjects on ...

Enzyme affects hypertension by controlling salt levels in body

...ls, in kidney cells that allow increased levels of sodium to be reabsorbed into the blood, researchers at UT..., which is well known to lead to the activation of sodium ion channels in kidney cells. "The kidney plays a very important role in controlling blood pressure ...

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(Date:11/18/2014)... Nov. 18, 2014  The Secure Identity & ... today jointly announce the formation of The Airport ... its Identity and Biometric Entry and Exit ... received official support from BORDERPOL, the international non-profit ... and provide expertise regarding border security, traveler and ...
(Date:11/15/2014)... , Nov. 13, 2014  While we may still ... Doctor McCoy used in "Star Trek" to gain instant access ... designed to work with smartphones and tablets for monitoring and ... the healthcare world. This may seem a tad Orwellian to ... to adopt some of these technological opportunities into their healthcare ...
(Date:11/7/2014)... led by Dr. Debra Auguste, associate professor, biomedical ... The City College of New York, have identified ... for one of the most aggressive forms of ... have a high mortality rate owing to aggressive ... therapeutic options. However, Professor Auguste,s team, discovered the ...
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