NIH awards new $14.5 million, five-year grant to the Scripps Research Institute
...echnique used. Smaller proteins may be most easily solved by NMR, larger proteins may require crystallograph...ing electron microscopy, Yeager and his colleagues solved and published the structure of the heart gap junction channel in a cover article in the journal Scie...Penn receives grant for initiative to help understand genes' effects on medications
...olutions to biomedical problems that have not been solved using traditional, disciplinary approaches," says NIH Director Elias A. Zerhouni, MD. The NIH initiative, fronted by the National Center for Research Resources, is part of the NIH Roadmap for Medical Research, which is intended to support and transfo...Lag-3 gene dampens immune responses by controlling regulatory T-cell function
...er issue of the journal Immunity. The researchers solved the mystery of what Lag-3 does by showing that the gene permits so-called regulatory T cells to act as brakes on the immune system. Regulatory T cells, which carry the Lag-3 protein on their surfaces, interfere with the ac...Darwin's greatest challenge tackled: the mystery of eye evolution
...ence of common evolutionary origin. We had finally solved one of the big mysteries in human eye evolution."...Structure of new DNA enzyme family member found
...e building blocks of all living organisms, and has solved 50 protein structures over the past 20 years. "From knowing the genetic sequence alone, we wouldn't necessarily guess that two proteins play a similar role in an organism." Zhang took just two months of "trial and error" -- an unusually short time --...Sea change: Skeletons of ancient corals different from today's
...Johns Hopkins University graduate student may have solved a problem that has been baffling marine biologists and paleontologists for years: Why do coral reefs disappear from the fossil record during the beginning of the Cretaceous period -- 120 million years ago -- only to reappear after its end 35 million ...New protein structure may aid in design of therapeutics for autoimmune disease
...Somers. "Moreover, the structure reported here was solved in the presence of the high potency protein kinase inhibitor, staurosporine, revealing the structural basis of inhibitor binding." Dr. Somers believes his results have the potential to aid in identifying selective inhibitors of kinase function t...Study identifies key aspect of immune response against HIV
...ard Medical School. "The AIDS crisis will only be solved with the development of an effective vaccine," says Bruce Walker, MD, director of the Partners AIDS Reseach Center at MGH and a co-author of the current study. "This study's results help to focus this effort by telling us what the most effective imm...Gene therapy reduces skin cancer to sunburn in mouse model
...nce some of the existing technical limitations are solved these studies can hopefully be extended to trials with human XP patients." Other UT Southwestern contributors to this research are Maria Carolina N. Marchetto, visiting student and lead author, and Dr. Dennis Burns, professor of pathology. D...Scientists solve the mystery of how Botox attacks nerves and eliminates wrinkles
...Stanford graduate student Mark A. Breidenbach have solved part of the puzzle. Their results, which will be published in the Dec. 12 online edition of the journal Nature, could help researchers develop alternative treatments for botulism and perhaps find new medical applications for Botox and other neurotoxi......used in the past. "The problem is basically solved in Banff," St. Clair said, adding that similar solutions may be possible for elk in other areas and for other animals like bears that are prone to habitutation. ...Vollum Institute discovery may unlock human genome
...an said. "And so, in a sense, declaring the genome solved was somewhat arbitrary because it's solved when you really understand it. If you look at the genome, or the database that the genome provided, ...Research may speed development of new oral drugs for fertility treatments
...drickson, was the structure of FSH, which had been solved by Dias and colleagues at the Wadsworth Center of the New York State Department of Health. Receptors such as FSH are switches that are situated in the cell membrane. When triggered by a molecular signal, such as a hormone, the switches activate speci...Chemists create 'Superbowl' molecule; May lead to better health
...ates are confident these potential problems can be solved with further testing and some clever chemical engineering. Funding for this study was provided by The Australian National University. In addition to Sherburn, study authors include Elizabeth S. Barrett and Alison J. Edwards, also with Australian Nat...... place, the number of protein structures they have solved has increased significantly. In the second, third,...ological structure data. "The protein structures solved by the PSI are more than a scientific stamp collection," explained Norvell. "They will help research...The BIOS Initiative - open source biotechnology is born
...health,poverty and hunger. These problems are best solved by empowering untapped resources -the countless creative people who are currently marginalized", says Jefferson, an influentialscientist who in 2003 was named as one of Scientific American's 50 Top TechnologyInnovators and is a Fellow of the Schwab F...Why do insects stop 'breathing'? To avoid damage from too much oxygen, say researchers
...igating the respiratory system of insects may have solved a mystery that has intrigued physiologists for decades: why insects routinely stop breathing for minutes at a time. Challenging previous theories, researchers at UC Irvine and Humboldt University propose that insects such as grasshoppers, moths, butt...Teams build robots that walk like humans
... because a large portion of the control problem is solved in the mechanical design. The MIT robot uses a learning program that exploits this design, allowing the robot to teach itself to walk in less than 20 minutes, or about 600 steps. Dubbed "Toddler" because it learns to walk and because it toddles when...Successful test of single molecule switch opens the door to biomolecular electronics
...se properties in conductance experiments. The team solved the problem by developing a technique where the mo... Recently, this problem this problem may have been solved by using the scanning probe microscope to make and measure single molecule contacts with molecules d...Antibody that neutralizes most HIV strains described by scientists at The Scripps Research Institute
...earch Institute and several other institutions has solved the structure of a rare human antibody that broadly neutralizes human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). Neutralizing antibodies are soluble proteins that are secreted by adaptive immune cells into...