Study begins to reveal clues to the cause and progression of sepsis
...heir results, treatments that completely abolish a specific component of the inflammatory response would be ineffective, and could be dangerous, since the inflammatory response is needed to address the underlying infection. Instead, they believe that therapies that address the chronic inflammatory response a...Unravelling new complexity in the genome
...eresting that many of the genes have important and specific functions in the nervous system, including roles associated with memory and learning. However, in most cases the investigators working on these genes were not aware that their favorite genes are regulated at the level of splicing. Blencowe believes t...Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
... state during progression of MM. Regardless of the specific method of activation, the NF-κB pathway plays a central role in MM pathogenesis and is an excellent target for development of new therapeutics....Interaction of just 2 genes governs coloration patterns in mice
...S Biology, marks one of the few instances in which specific genetic changes have been linked to an organism's ability to survive in the wild. "Our work shows how changes in just a few genes can greatly alter an organism's appearance," says Hopi E. Hoekstra, John L. Loeb Associate Professor of the Natural Sc...Bursts of waves drive immune system 'soldiers' toward invaders
... the wave itself. Using optical tricks to label specific pools of Hem-1, they found that molecules of Hem-1 don't move, but pass information between molecules to generate a wave. The research is now focusing on how external signals influence this wave generator to guide the cells. They also want to lear...Newly created cancer stem cells could aid breast cancer research
...st Tan Ince. Each cancer cell in the tumor plays a specific role, and just a fraction of the cells serve as qu... He transformed it into a cancer cell by inserting specific genes through a standard procedure. The engineered cells proved to be extremely powerful. When Inc...Does the desire to consume alcohol and tobacco come from our genetic makeup?
...functions relating to alcohol and smoking. Our sex specific findings may also play a role in the sex differences related to alcohol and tobacco use. ...X-ray images help explain limits to insect body size
...ts how big insects can be. The research provides a specific explanation for what limits size in beetles: the constriction leading to the legs. A collaborative team of researchers from Argonne's Advanced Photon Source (APS), Midwestern University and Arizona State University wanted to study how beetles' trac...Rain forest protection works in Peru
... found that the governments program of designating specific regions for legal logging, combined with protection of other forests, and the establishment of territories for indigenous peoples helped keep large-scale rain forest damage in check between the years 1999 and 2005. However, the research also showed a...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
... Dr. Dickeys research is to identify ways in which specific proteins accumulate in the brain and identify new drug targets for the treatment of Alzheimers disease. The study will focus on the removal of the accumulated proteins by manipulating a class of proteins called molecular chaperones. These chaperones ...Evolution is driven by gene regulation
...nctionally map these interactions and identify the specific targeted promoters, said Snyder. We were startled to find that even the closely related species of yeast had extensively differing patterns of regulation. In this study, the authors found the DNA binding sites by aiming at their function, rather th...JCI table of contents: Aug. 9, 2007
...protein PU.1 is a tumor suppressor. Mice lacking a specific portion of the DNA (known as the upstream regulatory element; URE) that controls the level of expression of the PU.1 gene develop acute myeloid leukemia (AML). When researchers from Harvard Medical School, Boston, analyzed the equivalent URE in human...European Science Foundation's Forward Look reaches out beyond the endless frontiers
... as frameworks to coordinate the dynamics of these specific fields at an international level. In the Forwar...uropean life sciences area. The result is a set of specific recommendations that aim at synergising Systems Biology efforts in Europe: Development of a com...Female gender provides an advantage in renal diseases
...udy will be presented at the APS meeting, but more specific data will be held until the study results are published. Presentation in Austin, TX Dr. Silbiger is discussing her work at the conference, Sex and Gender in Cardiovascular-Renal Physiology and Pathophysiology, being held August 9-12, 2007 at th...Research aims to identify markers for menopausal women at risk for deadly blood clot
...h brings us closer to defining risk profiles for a specific health issue. Our hope is that it can lead to tools that will allow doctors to provide hormonal therapy for their female patients that is commensurate with a womans risk for venous thrombosis. ...Grapes, soy and kudzu blunt some menopausal side effects
... young, estrogen-depleted rats. After ten weeks on specific diets, grape seed supplementation significantly reduced arterial pressure in the rats fed a high salt diet, compared to controls. The results indicate that grape seed polyphenols decrease arterial pressure in rats, probably via an antioxidant mechani...Secret life of elephant seals not secret anymore!
...ected by the seals show that the seals target very specific water bodies, Dr Rintoul said. An intriguing surprise was that the feeding preferences of the Atlantic seals were very different from seals tagged on Kerguelen and Macquarie Islands, in the Indian and Pacific sectors of the Southern Ocean, Dr Rinto...Other highlights in the Aug. 7 JNCI
...es to determine whether this loss of imprinting is specific to the IGF2 gene or whether it is part of a more general disruption of the epigenome. These results may have important therapeutic implications. Because of their potential reversibility, epigenetic modifications are under investigation as potentia...Cornell scientists link E. coli bacteria to Crohn's disease
...role in the development of Crohns disease, but the specific bacterial characteristics that drive the inflammat...ted a broad culture-independent approach to target specific subgroups of bacteria for quantitative in situ analysis and culture based characterization, said Ken...Role of thyroid hormones in slumber under investigation at Rutgers
...Camden will build on earlier findings by providing specific measurements of the levels of thyroid hormones and the compounds which are derived from them in the brain during circadian rhythms and during sleep and waking. Additional research will include observations of the effect of microinjections of thyroid ...