Next-era targeted therapy overcoming Gleevec's shortcomings
...s seamless," Giles says. "I don't work in a lab. I spend all my time with patients. But clinicians are now using molecular endpoints every day and in every way to direct our therapy and to design protocols. It is incredibly exciting."...Neural activity reveals continuity between infant and adult sleep
...Roffwarg and William Dement discovered that babies spend far more time in REM sleep than adults - prompting their hypothesis that infant REM sleep plays a role in central nervous system development. A central element of their hypothesis is built on whether the neural mechanisms of infant sleep differ sign...Elephant seal pups suffer from ocean warming
...lder waters, female seals have to swim further and spend more time searching for food. As a result, they gain less body mass while pregnant and have fewer reserves to draw on during nursing. Nursing pups get all nourishment from their mothers; changes in ocean temperature therefore directly affect the weig...Butterfly migration could be largest known
...lies, known by the scientific name Vanessa cardui, spend the winter in the desert. As caterpillars turn into adults in the spring, they migrate north in search of fresh food and breeding grounds, powered by a supply of yellow fat they have built up over the winter. Painted ladies migrate every year, but us...New technology, new approach to help heart and lung patients awaiting transplants
...arlier in treatment. "We in the medical community spend a lot of time helping patients live with heart failure until their bodies can't tolerate it any longer. Ironically, by the time we deem the candidate eligible for a heart transplant or a VAD, the patient may be so sick that he is no longer a good can...Europe faces brain drain and declining patient care unless cancer research funding is doubled
...ade Area) and found that: European Member States spend seven times less per person than the USA a funding gap far wider than previously thought; there is insufficient funding for preventative and clinical research, while funding for basic scientific research is proportionately much higher; Europe is w...Babies born preterm cost businesses big money: Hospital charges estimated at $7.4 billion annually
... March of Dimes noted that babies born prematurely spend significantly longer time in hospitals , have more...omson Medstat analysis found that premature babies spend nearly 17 days in the hospital over the 12 months following birth, compared to 2 to 3 days for healt...Quality of mom's time, not quantity, most important in early infant development
...chologists and parents worry that the time mothers spend away from their babies when at work detracts from ...ose three years. "The amount of time that mothers spend with their babies and at work are not the critical determinants of strong, positive mother-child rel...NIH should take decisive steps to promote independence, originality
...ies, and limit the maximum length of time they can spend in training under senior NIH-funded scientists to ...Is). Consequently, postdocs are often required to spend their time focused on the research of these senior investigators, a pattern that may stifle their cr...Harnessing microbes, one by one, to build a better nanoworld
... comprise the raw materials of nanotechnology. "We spend a lot of time making tiny little nanowires and things of that sort, and then we try to direct them in place, but it is very hard," says Hamers. "However, bacteria and other biological systems can be thought of as nature's nanowires that can be easily...Report highlights diseases from the environment
...hogens are defined as microorganisms that normally spend a substantial part of their lifecycle outside human hosts, but when introduced to humans cause disease with measurable frequency. They are carried in the water, soil, air, food and other parts of the environment and can affect almost every individua...Urgent measures needed to retain our lead in pharmaceuticals
...faced by pharmaceutical companies is that they may spend enormous sums on developing a new drug only to find that it works well with 60% of the population but not with the remainder. In the past this has always led to the product being shelved. A way out of this wasteful impasse, "Personalised medicine", i...Studies reveal methods viruses use to sidestep immune system
...e unimpeded. "Having identified RIG-I, now we can spend our time completely defining the signaling pathway that goes from RIG-I all the way down to IRF-3," Dr. Gale said. "Once we've done that, we hope to identify parts of the pathway to target with drugs to try to limit infection." Drugs called proteas...Reviewing scientists say proposed conservation measures unlikely to help whales
...les that the sanctuaries are meant to protect also spend part of the year in areas where they would be vulnerable to capture by whalers. "There is a growing body of literature on marine reserves and empirical evidence about the effects of reserves from around the world. There is a general consensus among ...Stem cell therapy for ailing hearts
...eart failure due to heart attacks and other causes spend much of their day at home in a chair or in bed. These are the patients whose lives we hope to greatly improve with stem cell therapy to restore heart function," said Dr. Henning, lead author of the study. "Our initial results are extremely promisin...Urban ecology study witnessing the birth of a 'designer ecosystem'
...s, most of whom are mainly seed-eating species, to spend more time hunting nutrient-rich insects, a behavior that would be risky around predators. Other behavioral and trophic shifts also appear to follow. Particularly intriguing is the further implication that populations and trophic structures vary some...$6.7 million for bionic war on disabilities
...trol a computer with their thoughts. "We plan to spend this $6.7 million to further develop technology that we hope will someday help blind individuals see, allow paraplegics to stand and eventually walk, and let people with vocal cord problems speak," says Richard Normann, a professor of bioengineering ...'Casanova' field crickets - live fast, die young
...ell-fed male field crickets die young because they spend too much time courting members of the opposite sex, according to research by Australian scientists in the latest edition of Nature . The results reveal how male crickets (Teleogryllus commodus) fed on a high protein diet engaged in more "sexual call...Hummingbirds lose power at high altitudes
...marginal power at high elevations. "When you spend a lot of time watching hummingbirds, you realize they engage in an amazing suite of maneuvers, above and beyond hovering at flowers for nectar or insects," he said. "They are constantly using much more mechanical power to do other interesting things,...Europe's fishermen should have marine 'stewardship' role, says study
...ations, managing them for a common good. Fishermen spend their lives at sea, they know and understand the environment, and this scheme can help them play a more direct role in the stewardship of our fish stocks, marine life and maritime heritage. "The Fisheries Ecosystem process should also be about ensur...