Tag: "splicing" at biology news

Phillip A. Sharp to present 2004 Ullyot Public Affairs Lecture at Chemical Heritage Foundation

...ry records of achievement. Sharp codiscovered RNA splicing in 1977. This work provided one of the first indications of the startling phenomenon of "discontinuous genes" in mammalian cells. The discovery that genes contain nonsense segments that are edited out by cells in the course of utilizing genetic infor...

New version of tumor-suppressor linked to progression of childhood cancer

...nd that the level of TrkIII resulting from altered splicing of TrkA transcripts is controlled in part by hypox...lating NB progression based on alternative TrkAIII splicing rather than genetic TrkA abnormality would theoretically permit reversal by re-establishing regular ...

Chicken genomic sequence yields insight into vertebrate evolution

...ice sites in vertebrates. Their findings show how splicing has changed very slowly over time, and that even w...in their function. While splicing has largely been conserved over evolutionary time, another interesting biological mechanism namely,...

New technique provides insights into gene regulation

...ics and Microbiology, who notes out-of-control RNA splicing is involved in many human diseases, including cancers and birth defects. "The new information we can now obtain could also provide insights into new treatments." Each cell in the human body contains about 25,000 genes. Although human tissues and org...

Cells don festive holiday colors

...lls and observe a range of cellular processes. By splicing the genes for the fluorescent proteins into specific genes in the cell, researchers can detect when those genes are switched on to produce proteins. They can then use the telltale fluorescent colors to separate the cells visually. The availability of...

UCSD medical researchers discover molecular pathway that turns a juvenile heart into an adult heart

...ion in a vital cellular process called alternative splicing the mechanism through which a single gene can gen...me set of amino acid building blocks. Alternative splicing occurs at all stages of development, including the period of transition from juvenile to adult life,...

Multi-purpose protein regulates new protein synthesis and immune cell development

...hat IRE1 triggers the unfolded protein response by splicing a segment of messenger RNA called XBP1. This leads to production of a new protein, which turns on genes in the UPR signaling pathway and directs cells to secrete large amounts of protein. The University of Michigan has filed a U.S. patent application...

Controlling protein diversity

...iology. The answer is a process called alternative splicing in which certain information from a gene is left o... unusual in that they can both control alternative splicing that results in different proteins being made as well as the production of RNA....

Researchers find missing genes of ancient organism

...nes for tRNA in an ancient parasite are made up by splicing together sequences in distant parts of the DNA genome. The research led by Professor Dieter Sll in the Department of Molecular Biophysics and Biochemistry at Yale focuses on the most ancient organism with a known genome sequence. Nanoarchaeum equ...

New study explains process leading to many proteins from one gene

...making several different proteins. "Alternative splicing is a key mechanism for achieving a diverse range o...udy aimed at understanding how and why alternative splicing occurs in humans. The study is available online and will be published in the April 15 issue of the...

Single gene is genetic switch for fly sexual behavior

...the fruitless protein, as a result of sex-specific splicing of the mRNA. The male form of Fruitless is critica...male form, suggesting that male-specific fruitless splicing "not only promotes male-female courtship, it also inhibits male-male courtship," the researchers say...

Cancer comes full circle

...ith dramatically different activities. Alternative splicing is emerging as a key mechanism for controlling cellular function, and identification of MMPs as influencing these processes provides a unique tool for understanding their regulation." Finding new mechanisms of cancer control can lead to specific o...

Modification of program enables prediction of gene transcription

...xtra-long untranslated region is then discarded by splicing the 5' untranslated region (UTR). All present gene finding systems except for N-SCAN either ignore the UTR splice sites or incorrectly incorporate them into some protein-coding segment, making gene prediction a none-too-sure industry. "We...

Key process in gene regulation occurs in blood platelets, Univeristy of Utah researchers find

...of study subjects, the Utah researchers found that splicing also takes place in the cytoplasm of circulating p... Eccles Institute of Human Genetics. "To find that splicing takes place outside the nucleus has potential implications beyond the platelet. It suggests that, un...

Spliceosomal fidelity

Pre-messenger RNA (pre-mRNA) splicing is an integral step in gene expression, removing i... Christine Guthrie at UCSF have identified a novel splicing fidelity factor, as well as provide additional evidence for a two-step model of pre-mRNA splicing. ...

Temperature sensing by the circadian clock

...spora. The scientists investigated thermosensitive splicing of the central clockwork protein, FREQUENCY (FRQ),...onsensus signals - in this case the interaction of splicing machinery with non-consensus splice sites and the interaction of ribosomes with non-consensus transl...

Alteration of brain protein regulates learning

... the new amino acids is similar to cutting a rope, splicing in a short portion, and lashing the ends in place. This longer form of Apoer2 is necessary for reelin to act upon the NMDA receptor, Dr. Herz and his colleagues found. When reelin binds to the longer Apoer2, the NMDA receptor alters its structure an...

Carnegie Mellon University research reveals how cells process large genes

...sciences at Carnegie Mellon. Ultimately, recursive splicing could be responsible for thwarting molecular misha...ny large introns are removed by multiple recursive splicing steps," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work a...

Rett gene regulates alternative splicing

...some of these proteins to synapse. Alternative RNA splicing is one way for the cell to create many different f...t beginning to learn the importance of alternative splicing in neuronal activity."Zoghbi discovered the role of the gene methyl-CpG binding protein 2 (MeCP2) in...

RSRF-funded research yields novel function for Rett syndrome gene

...e as a transcriptional repressor it also acts as a splicing regulator. In support of this finding Zoghbi and colleagues observed alternative splicing abnormalities in the mutant mouse model for RTT. "The finding that MeCP2 functions in two steps of ...

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(Date:10/30/2014)... York | Heidelberg, 30 October 2014 Biological membranes ... better understanding of adsorption of solution ions onto ... cells. Now, a new study provides a quantitative ... surrounding solution ions. Joanna Kotyńska and Zbigniew Figaszewski ... authors of a study describing these findings, just ...
(Date:10/29/2014)... released by unconventional oil and gas production are well ... in the open access journal Environmental Health . ... found. The study is the first to be based ... sites and could be used to supplement official air-quality ... reserves that do not readily flow to the surface. ...
(Date:10/29/2014)... the largest study of its kind to date, researchers ... that heighten the risk for autism. Joseph Buxbaum, Ph.D., ... City, Mark Daly, Ph.D., Broad Institute of Harvard and ... samples from affected children, parents and unrelated people. They ... contribute to the risk for autism spectrum disorder (ASD) ...
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