Tag: "splicing" at biology news
Phillip A. Sharp to present 2004 Ullyot Public Affairs Lecture at Chemical Heritage Foundation
...ry records of achievement. Sharp codiscovered RNA splicing
in 1977. This work provided one of the first indications of the startling phenomenon of "discontinuous genes" in mammalian cells. The discovery that genes contain nonsense segments that are edited out by cells in the course of utilizing genetic infor...
New version of tumor-suppressor linked to progression of childhood cancer
...nd that the level of TrkIII resulting from altered splicing
of TrkA transcripts is controlled in part by hypox...lating NB progression based on alternative TrkAIII splicing
rather than genetic TrkA abnormality would theoretically permit reversal by re-establishing regular ...
Chicken genomic sequence yields insight into vertebrate evolution
...ice sites in vertebrates. Their findings show how splicing
has changed very slowly over time, and that even w...in their function. While splicing
has largely been conserved over evolutionary time, another interesting biological mechanism namely,...
New technique provides insights into gene regulation
...ics and Microbiology, who notes out-of-control RNA splicing
is involved in many human diseases, including cancers and birth defects. "The new information we can now obtain could also provide insights into new treatments." Each cell in the human body contains about 25,000 genes. Although human tissues and org...
Cells don festive holiday colors
...lls and observe a range of cellular processes. By splicing
the genes for the fluorescent proteins into specific genes in the cell, researchers can detect when those genes are switched on to produce proteins. They can then use the telltale fluorescent colors to separate the cells visually. The availability of...
UCSD medical researchers discover molecular pathway that turns a juvenile heart into an adult heart
...ion in a vital cellular process called alternative splicing
the mechanism through which a single gene can gen...me set of amino acid building blocks. Alternative splicing
occurs at all stages of development, including the period of transition from juvenile to adult life,...
Multi-purpose protein regulates new protein synthesis and immune cell development
...hat IRE1 triggers the unfolded protein response by splicing
a segment of messenger RNA called XBP1. This leads to production of a new protein, which turns on genes in the UPR signaling pathway and directs cells to secrete large amounts of protein. The University of Michigan has filed a U.S. patent application...
Controlling protein diversity
...iology. The answer is a process called alternative splicing
in which certain information from a gene is left o... unusual in that they can both control alternative splicing
that results in different proteins being made as well as the production of RNA....
Researchers find missing genes of ancient organism
...nes for tRNA in an ancient parasite are made up by splicing
together sequences in distant parts of the DNA genome. The research led by Professor Dieter Sll in the Department of Molecular Biophysics and Biochemistry at Yale focuses on the most ancient organism with a known genome sequence. Nanoarchaeum equ...
New study explains process leading to many proteins from one gene
...making several different proteins. "Alternative splicing
is a key mechanism for achieving a diverse range o...udy aimed at understanding how and why alternative splicing
occurs in humans. The study is available online and will be published in the April 15 issue of the...
Single gene is genetic switch for fly sexual behavior
...the fruitless protein, as a result of sex-specific splicing
of the mRNA. The male form of Fruitless is critica...male form, suggesting that male-specific fruitless splicing
"not only promotes male-female courtship, it also inhibits male-male courtship," the researchers say...
Cancer comes full circle
...ith dramatically different activities. Alternative splicing
is emerging as a key mechanism for controlling cellular function, and identification of MMPs as influencing these processes provides a unique tool for understanding their regulation." Finding new mechanisms of cancer control can lead to specific o...
Modification of program enables prediction of gene transcription
...xtra-long untranslated region is then discarded by splicing
the 5' untranslated region (UTR). All present gene finding systems except for N-SCAN either ignore the UTR splice sites or incorrectly incorporate them into some protein-coding segment, making gene prediction a none-too-sure industry. "We...
Key process in gene regulation occurs in blood platelets, Univeristy of Utah researchers find
...of study subjects, the Utah researchers found that splicing
also takes place in the cytoplasm of circulating p... Eccles Institute of Human Genetics. "To find that splicing
takes place outside the nucleus has potential implications beyond the platelet. It suggests that, un...
Pre-messenger RNA (pre-mRNA) splicing
is an integral step in gene expression, removing i... Christine Guthrie at UCSF have identified a novel splicing
fidelity factor, as well as provide additional evidence for a two-step model of pre-mRNA splicing. ...
Temperature sensing by the circadian clock
...spora. The scientists investigated thermosensitive splicing
of the central clockwork protein, FREQUENCY (FRQ),...onsensus signals - in this case the interaction of splicing
machinery with non-consensus splice sites and the interaction of ribosomes with non-consensus transl...
Alteration of brain protein regulates learning
... the new amino acids is similar to cutting a rope, splicing
in a short portion, and lashing the ends in place. This longer form of Apoer2 is necessary for reelin to act upon the NMDA receptor, Dr. Herz and his colleagues found. When reelin binds to the longer Apoer2, the NMDA receptor alters its structure an...
Carnegie Mellon University research reveals how cells process large genes
...sciences at Carnegie Mellon. Ultimately, recursive splicing
could be responsible for thwarting molecular misha...ny large introns are removed by multiple recursive splicing
steps," Lopez said. "These steps involve the sequential excision of smaller subfragments. Our work a...
Rett gene regulates alternative splicing
...some of these proteins to synapse. Alternative RNA splicing
is one way for the cell to create many different f...t beginning to learn the importance of alternative splicing
in neuronal activity."Zoghbi discovered the role of the gene methyl-CpG binding protein 2 (MeCP2) in...
RSRF-funded research yields novel function for Rett syndrome gene
...e as a transcriptional repressor it also acts as a splicing
regulator. In support of this finding Zoghbi and colleagues observed alternative splicing
abnormalities in the mutant mouse model for RTT. "The finding that MeCP2 functions in two steps of ...