Biologists ID molecular block for social 'cheaters'
... Before forming a stalk, the colony goes through a stage where it forms a slug-like structure. During this ...es from the rest of the group and enter a prestalk stage of development. Using biotechnology, the research team created a mutant strain of Dictyostelium with...Obese women with early-stage breast cancer more likely to die than women of normal weight
...of the study. "Despite being diagnosed with early stage disease, which is more commonly cured, obese women... the data of 2,010 patients from 1978 to 2003 with stage I/II breast cancer who were treated with lumpectomy, lymph-node dissection and radiation therapy wit...Study describes basic mechanism in cell growth control involving damaged DNA
...ions of cellular proteins increasingly take center stage in basic biomedical research, studies are revealing a complex molecular choreography with implications for human health and disease. In a report currently appearing in the online issue of the journal Nature Cell Biology, scientists at the University ...Cooperation to create a new tuberculosis vaccine
...s challenging mission. This still is a preclinical stage project, but our cooperation will add significant value to this new vaccination approach. There is a significant commercial perspective in developing as well as in developed countries. If our tests prove successful we will decide if we carry on with ...Researchers provide road map for generating B cells from stem cells
...y, activating genes that move the cell to the next stage and enabling the cell to respond to specific chemi...process, nudging a multi-potent progenitor cell -- stage 1, which could become any type of blood cell -- toward becoming a lymphoid progenitor, stage 2. The...FSU scientist links iron imbalance to Parkinson's disease
...lay the onset of the disease once the neurological stage is set or slow the degenerative progress, iron toxicity both precipitates Parkinson's symptoms and hastens decline and death in existing victims. Until further studies determine optimal levels of the essential nutrient, Levenson advises heal...New study on smallpox in monkeys reveals tactics of a killer
..., also published online in PNAS this week, set the stage for Dr. Relman's smallpox study. In this work, researchers at the U.S. Army Medical Research Institute of Infectious Diseases, the Centers for Disease Control and Prevention (CDC) and Stanford University, show that cynomolgus macaque monkeys exposed ...Technique for genetically modifying blood stem cells brings cure for blood diseases closer
...) because it normally occurs only during the fetal stage of development. The use of HbF prevents the need to introduce normal beta-globin into the body in someone who has never had it before. It is possible that the sudden introduction of beta-globin could trigger an immune response against this protein. ...Muscling in on a deadly cancer
...d be converted into a Pax3-Fkhr fusion gene at any stage of embryo development and in any desired cells a new technology called "conditional mutagenesis." Capecchi says these experiments revealed how the fusion gene turns various genes on or off, interfering with normal muscle development and providing cl...The long road to a promising malaria vaccine started at NYU School of Medicine
...salivary glands of the Anopheles mosquito. At that stage it is a crescent-shaped and called sporozoite, a stage in the complex life cycle of the parasite before it invades the human liver and causes devastating i...New version of tumor-suppressor linked to progression of childhood cancer
...n NB cells. TrkIII levels are elevated in advanced stage NB tumors, suggesting that the molecule may play a role in cancer progression. The researchers found that the level of TrkIII resulting from altered splicing of TrkA transcripts is controlled in part by hypoxia, a condition where cells are deprived o...Peakadilly nv biopharmaceutical firm created
...d its product potential were presented in an early stage to a select group of (bio)pharmaceutical firms, the need for such a technology and products proved to be so large that R&D collaborations at a value of around 2 million euro were quickly established with 3 well-known firms. These collaborations...Combination hormone therapy doubles breast density and quadruples risk of abnormal mammograms
...mammograms for detecting early breast cancers at a stage when they are most treatable." In addition, McTiernan and colleagues suggest that health-care providers may want to track breast-density change during regular mammography screenings and use this information as part of the risk-benefit assessment whe......y found in cartilage was reduced, although at this stage the knee, for example, looked normal. By 7 weeks old (adulthood for mice), there were clear structural changes in the knee joints, and the articular cartilage was thinner and showed signs of wearing away. By 9 months old, the knees of the mutant mice...New method studies living bacterial cells
...ngle bacterial cells. The new capabilities set the stage for future studies defining mineral-metal-microbe interactions in contaminated environments. "This technique also should be directly applicable to investigations of microbial processes in extreme subsurface environments and to studies of a variety o...Brain differences in adolescents, psychopaths, lend to their impulsive, risk-taking behavior
...sts now urge that puberty be studied as a separate stage of development--one distinctly different from the ...ge. "Puberty appears to be a specialized stage of development in which males and females are more likely to explore novel environments," Hodes says...Moffitt doctor's talk on ovarian cancer receives international first place award
...o individualize therapy for patients with advanced stage ovarian cancers. Lancaster sought to develop gene expression profiles that predict response to platinum-based chemotherapy using microarray expression analysis. Data obtained from cancers of patients who demonstrated a complete response to platinum...Yerkes researchers to present array of new data at Society for Neuroscience Meeting
...hat controls motor function. This finding sets the stage for further analysis of the role of these proteins in the development of Parkinson's disease. (5 pm 8 pm.) October 25, 2004 Each study is embargoed until the date and time of presentation. Symposium Dr. Young: how development, social situati...... avoid being excreted at a particularly vulnerable stage of its development. "Identifying and targeting midgut molecules essential for parasite survival represents a novel strategy for development of transmission-blocking vaccines against vector-borne diseases," Valenzuela and colleagues conclude. As Steph...... the post blastula but pre-hatching embryo at this stage is beginning to transform into a spiral animal. Each such animal had three clockwise spires. After hatching, the spiral organism began to uncoil slightly," Xiao said. "They look as if they can unwind to a tube structure. We are looking for more evide...