Highlights of chemical society national meeting in San Diego, March 13-17
...om the blood. This mechanism is similar to that of statin drugs, they say. The study also showed that apple extracts prevent the bad (LDL) cholesterol from turning into oxidized LDL, a potentially more deadly form of bad cholesterol that is associated with an increased risk of heart attack and stroke. Anoth...Study reveals potential new target for cholesterol-lowering drugs
...eting PCSK9 may be able to act in conjunction with statin drugs to further lower LDL cholesterol levels. Dr. Horton said cholesterol-lowering drugs based on blocking PCSK9 might be effective on their own as well, providing another option for individuals unable to take statins. Statins increase the activit...Statins, other cholesterol depletors, may disrupt hypertension development: UCSD study
...rol-lowering agents, such as the widely-prescribed statin drugs, and cholesterol-blocking agents may prove t...esterol (methyl-beta-cyclodextrin, or MBCD), or "a statin (in this case, lovostatin, sold as Mevacor by Merck), which blocks cholesterol synthesis, resulted i...Combination of Lipitor and Celecoxib
...ence and progression of colon cancer. Lipitor, a statin drug aimed at lowering cholesterol and used in humans primarily in support of cardiovascular health, reduces cholesterol that is processed into tumorogenic molecules in the intestine. "Cholesterol is a substrate of the bile acid synthesis in the li...Cancer research finds targets for new cholesterol-lowering therapies
...t a two-pronged attack on LDL removal, combining a statin with a treatment that prevents Fbw7/SREBP interaction would likely be of more benefit to some patients than statins alone." Dr. Ericsson said that the team also found that the Fbw7/SREBP interaction may also be connected to diabetes, as insulin sign...New study demonstrated add-on effects of ACTOS (pioglitazone HCl)
...tudy has shown that people with type 2 diabetes on statin therapy for diabetic dyslipidemia who were switche...se resulting from traditional cholesterol-lowering statin therapy, in key lipid parameters. These effects were independent of blood glucose control, which re...First link found between obesity, inflammation and vascular disease
... good news: the researchers found that aspirin and statin drugs, now commonly used to treat heart diseases, ... other part of the puzzle why it is that aspirin, statin drugs and an agent known as troglitazone, used to treat diabetes, can reduce CRP levels. They expose...UT Southwestern physician-researcher wins international award for lipid research
...sterol metabolism, which led to the development of statin drugs to treat high cholesterol. Dr. John Dietschy, professor of internal medicine, received the Wieland Prize in 1983 for his research into the regulation of cholesterol balance in tissues. Dr. David Mangelsdorf, professor of pharmacology and bioche...Recreating 'Flowers for Algernon' with a happy ending
...1 mice would jump off as the log spun faster. But statin therapy enabled the NF1 mice to perform as well as their normal counterparts. "This is mind-blowing we think we have a real fundamental reason to be optimistic," explained Silva. "Here is a drug that affects a key learning and memory pathway, and ...This week, researchers report evidence that a statin drug already shown to be safe for use in humans ha...nt Biology demonstrates that a commonly prescribed statin drug, Lovastatin, can reverse the overactivity of Ras, decrease inhibition, repair the cell-cell com...Cholesterol-lowering drugs not associated with reduced colorectal cancer risk
... type of study, found no clear association between statin use and colorectal cancer, but these trials were relatively small and did not examine long-term statin use. In contrast, a recent large study, the Molecular Epidemiology of Colorectal Cancer (MECC) stud...Red grapefruit appears to lower cholesterol, fight heart disease
...gh lipid levels failed to respond significantly to statin drugs. Statins are commonly prescribed to lower cholesterol, according to study leader Shela Gorinstein, Ph.D., a chief scientist at the Hebrew University of Jerusalem. The patients, equally divided into three treatment groups, were given either a si...Cholesterol-lowering foods most effective when combined, U of T study
...ults achieved by 29 of the participants who took a statin for one month under metabolically controlled conditions before following the diet under real-world conditions. "The study's findings suggest that the average person can do a lot to improve their health through diet," Jenkins says. "People interested...New evidence suggests statins could prove useful in treating MS
...utiny, adding a relatively inexpensive drug like a statin to an already expensive regimen is likely to make consumers and health care insurers even more enthusiastic about combination therapies." The finding is the latest step in elucidating the potential of Lipitor to treat MS. It follows a study of mouse ...Chemist wins national award for contributions in medicinal chemistry
...erapeutic agents. Out of this effort came Zocor, a statin widely prescribed for lowering cholesterol, and Trusopt, a carbonic anhydrase inhibitor used to treat glaucoma. More recently, Anderson has directed research efforts at Merck and DuPont Pharmaceuticals on chemotherapeutic agents for the treatment of ...Moderate lifetime reductions in LDL cholesterol dramatically reduce risk of heart disease
...tions keep LDL low over a lifetime, not just after statin treatment is begun typically when a patient is in...K9 are healthy, Hobbs is optimistic that combining statin therapy and drugs that target PCSK9 might be particularly effective at reducing the risk of heart di...Lowering cholesterol early in life protects against heart disease later
...rugs prescribed to lower LDL in patients. However, statin treatment may increase the production of the PCSK9 enzyme, Dr. Hobbs said, which in turn may limit the effectiveness of these drugs. Developing new therapies that inhibit PCSK9 activity not only should lower LDL levels, but in addition, might enhance...Research provides clues to obesity's cause and hints of new approach for curbing appetite
...comes of obese patients who are being treated with statin drugs, such as Lipitor and Zocor, for high cholesterol. Recent studies have found that statin drugs lower levels of CRP as well. Working with David E. Kelly, M.D., professor of medicine and dire...Researcher predicts paradigm shift in heart disease treatment
...l see something similar to what evolved out of the statin trials," explained Dr. Aronne. "Some of these drugs may be better than others and some of them may be remarkably similar." "In the future, we'll see a paradigm shift, or a change in the treatment of cardiometabolic risk," said Dr. Aronne. "Instead of...Nanotechnology shows early promise to treat cardiovascular disease
...essel sites. Their approach contrasts with today's statin drug therapy, which aims to reduce the amount of low density lipids, or LDLs ("bad" cholesterol), throughout the body. In an ironic twist, the Rutgers approach aims to thwart a biological process that is typically beneficial and necessary. Prabhas Mo...