ESF EURYI award winner aims to stop cancer cells reading their own DNA
...ls (EuroHORCS). Dekker and her team are trying to stop tumor development by interfering with the molecular motors that copy DNA during cell division. This will cut off the genetic information flow that tumours need to grow, and could complement existing cancer therapies, while in the longer term bringing...Penn researchers discover how key protein stops inflammation
...explains Chen. Without Bcl-3, Chen says p50 cannot stop the inflammation response, but instead will become degraded very fast, through ubiquintination. Ubiquitination is an intracellular system of checks and balances, where cellular proteins are flagged for disposal. During exposure to infection, Bcl-3 ...UCLA scientists produce functioning neurons from human embryonic stem cells
...s to these debilitating diseases and find a way to stop or treat it. Sun will be among the first researchers to be able to study true neuron function. A second important discovery in Suns study showed that two embryonic stem cells lines derived in similar manners, and therefore expected to behave si......other drawbacks of those used now, can effectively stop the bug in its tracks. Bacillus anthracis can quickly transform from a dormant spore (the white powder sent to U.S. lawmakers and others in the mail in 2001) into an active, quickly-multiplying organism once it gets inside the warm lungs of a host....Boston Univeristy bioengineers devise 'dimmer swith' to regulate gene expression in mammal cells
...get around this by entirely snipping out a gene to stop production of a specific protein, but this approach is irreversible. To overcome these challenges, Tara came up with a design that really combined two different technologies to repress or shut down gene expression, Collins added. We said, okay, wev...Researchers watch antibiotics, bacteria meet at atomic level
...ll prevent its movements, then we will immediately stop the action of RNA polymerase, and bacteria will die soon thereafter. The team's findings may be applicable to realms outside microbiology and drug discovery. Such a clear picture of the RNA polymerase elongation complex may be useful to a number of...Other highlights in the July 24 JNCI
...mote tumor growth while its withdrawal may slow or stop it. They add that using individual-basedin addition to population-baseddata would give researchers a better picture of relationship between hormone therapy use and breast cancer. These additional analyses will be hopefully forthcoming from registr...1 in 4 NYC adults has elevated blood mercury levels
...use the brain is still developing. No one needs to stop eating fish, but some people may need to change the type and amount they eat, Kass said. Young children, breastfeeding mothers, and women who are pregnant or planning pregnancy should eat fish that are lower in mercury and limit fish that are higher ...Disease-free mosquito bred to disease-carrier can have all disease-free progeny
...t, such as a gene that directs the dengue virus to stop replication. The research reported in PNAS shows that we can access the female germline and we can perform experiments in the germline, said Adelman. The nanos control sequences show promise as a part of a TE-based gene drive system, he said....Scientists take next step in understanding potential target for ovarian cancer treatment
...er protein that tells components in the nucleus to stop cell growth. The discovery of this additional role...e cell nucleus to turn on specific genes that help stop cell growth. Alterations in the TGF signaling system are known to contribute to cancer, Mulder sa......ic attacks stem from the inability of the brain to stop experiencing the fear associated with a specific incident or series of incidents. For some people, upsetting memories of traumatic events do not go away on their own, or may even get worse over time, severely affecting their lives. Treating these d...Major breakthrough in understanding how HIV interferes with infected cell division
... cellular protein complex targeted by HIV-1 Vpr to stop infected cell division. This protein complex, designated DDB1-CUL4-VprBP, is involved in a process called ubiquitination. Ubiquitination is a mechanism by which a small protein called ubiquitin is conjugated to cellular proteins in order to modulate ...New way to target and kill antibiotic-resistant bacteria found
...EL HILL -- Putting bacteria on birth control could stop the spread of drug-resistant microbes, and researchers at the University of North Carolina at Chapel Hill have found a way to do just that. The team discovered a key weakness in the enzyme that helps fertile bacteria swap genes for drug resistance...Research ends debate over benefits of butterfly defenses
... that the birds eventually learnt that in order to stop mistakenly eating the distasteful prey, they must stop eating both species altogether. We can now apply this model to other insects that use mimicking t...Skin rash actually signifies better outcomes for pancreatic and lung cancer patients
...rceva outside of a clinical trial may be likely to stop treatment. Some patients are stopping treatment because of the rash, yet those are the ones who are most likely to benefit, Wacker said. This is a critical problem and rather than permanently discontinue treatment, patients should talk to their do...New approaches to endometriosis treatment -- mouse experiments point the way
...hat they have been used for many years in order to stop breastfeeding, for example, without any major side effects, says Dr. Novella-Maestre, so we decided to see what effect they would have on the experimental mice. The scientists found that the blood vessel formation in the lesions was significantly d...Cell receptor may lead to new 'biomarker' for pancreatic cancer
...receptor and the standard chemotherapy drugs might stop progression of pancreatic cancer more effectively, says Waltz. RON could be a promising molecular target for future cancer drug development. Waltz stresses, however, that additional preclinical research is needed before RON receptor blockers become...Doing nature one better: Expanding the genetic code in living mammalian cells
...codons encoding 20 different amino acids and three stop signals. Being able to expand the code and insert ...nstructions spelled out in the genetic code till a stop codon for which no corresponding tRNA/amino acid pair exists lets everybody know that this particu......The idea is to suppress inflammation so that cells stop producing MIF, said Dr. Al-Abed. Every year, 215,000 Americans die of sepsis, a systemic inflammatory reaction to infection. Another 500,000 survive the infection, and scientists are still trying to figure out why these patients survive and others ......y to environmental cues that cause normal cells to stop growing. Hence, the discovery that too much HEF1 and Aurora A cause cilia to disassemble provides important hints into what may be happening in cancers. Defects in cilia have already been identified in one disease that represents a significant pub...