Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
...scientists compared two different rat strains; the strains possessed virtually identical nuclear genomes but ...ome. Any differences observed between the two rat strains could be attributed to variation in the mitochondria. When comparing the two rat strains, the rese...How cells change the pace of their steps
...uch as Dictyostelium, we are able to design mutant strains that will permit us to dissect each component of the cell movement cycle, thus allowing us to understand the function of each biochemical part and how the whole system works in concert. As the Dictyostelium cells moved on the elastic substrate the...Identified mechanism in the malaria parasite to help it adapt to infected individuals
...nced, and well follow this up with studies on wild strains of the parasite, concludes Corts. The scientist, who leads a research line in molecular parasitology in the Genetic Translation Laboratory at IRB Barcelona, emphasises that this study has also revealed that none of these proteins acting on its own ...Handicapping tuberculosis may be the way to a better vaccine
...They altered the normal and the apoptosis-inducing strains of TB to produce this peptide. The researchers tr...normal mice, which they then infected with the two strains of TB. This procedure gives scientists a magnified view of the immune systems response. Although bot...Developing a more effective vaccine for tuberculosis
... as CD8+ T cells are more efficiently activated by strains of M. Tuberculosis that lack a protein known as SecA2 than strains of M. Tuberculosis that express SecA2. Efficient CD8+ T cell activation was associated with increase...JCI table of contents: August 1, 2007
... as CD8+ T cells are more efficiently activated by strains of M. Tuberculosis that lack a protein known as SecA2 than strains of M. Tuberculosis that express SecA2. Efficient CD8+ T cell activation was associated with increase...Strains of laboratory mice more varied than previously thought
...that the genetic variation in the most widely used strains of laboratory mice is vastly greater than previous...the study found that the pedigrees of the 15 mouse strains studied are not what they were previously assumed to be. It appears they differ from each other to a...Monell researchers find metabolic defect in liver that can lead to obesity
...e when fed a high-fat diet. The closely-related strains weigh the same and eat the same amount of calories when fed a low-fat diet. However, when switched to a high-fat diet, the strain that is obesity-prone overeats and becomes obese, while the obesity-resistant strain does not. The researchers found......ch detailed differences distinguish the genomes of strains from the polar circle or the subtropics, from Amer...searchers compared the genetic material of 19 wild strains with that of the genome of the lab strain, which was sequenced in the year 2000. Using a very elabor...JCI table of contents: July 19, 2007
... UT Southwestern Medical Center examined different strains of lupus-prone mice in order to address this question. They report that different signaling pathways are upregulated in lupus B cells as the disease evolves. However, the very same pathways are shown to be upregulated in B cells from mice with differ...Charting ever-changing genomes
...scientists catalogued the genetic variations in 23 strains of the mustard weed Arabidopsis thaliana that were...titute -- went through the genomes of 20 different strains of Arabidopsis thaliana with an even finer-toothed comb, allowing them to determine the exact nature...Study explains how pathogens evolve to escape detection
...syringae and trigger an immune response. But some strains of P. syringae have evolved the AvrPtoB protein ...tein still detects AvrPtoB-like proteins from some strains of P. syringae , prompting an effective immune response, the researchers believe new P. syringae ...Universal flu vaccine being tested on humans
...ne is intended to provide protection against all A strains of the virus that causes human influenza, includin...he flu virus mutates regularly, giving rise to new strains of flu. Due to these frequent mutations, the virus is able to elude the antibodies that have been bu...University of Colorado licenses two influenza virus detection discoveries to Quidel Corp.
...ratory. The BChip can detect two influenza B virus strains (B/Victoria/2/87 and B/Yamagata/16/88), which are critical in determining seasonal influenza vaccines. In a recent study of 62 influenza B virus samples from 19 countries, dating from 1945 to 2005, as well as five negative control samples, the BC...UT and Atom Sciences Collaborate on NIH grant to develop test for major african disease
...and Small will compare test results with different strains of the bacteria to refine the diagnostic's ability to detect the subtle genetic differences between bacteria that come from different environmental sources, such as contaminated water sources. By understanding the sources, medical professionals and...Tips from the Journals of the American Society for Microbiology
...of influenza viruses in humans and found that some strains currently circulating throughout the world may transmit better than others in mammals. The researchers report their findings in the July 2007 issue of the Journal of Virology. Transmission of H5N1 influenza viruses is of great concern worldwide ...A new plant-bacterial symbiotic mechanism promising
...searchers sequenced (3) the genes of two bacterial strains of Bradyrhizobium, ORS278 and BTAi1, in order to find out their genetic make-up and identify the genes involved in this rather special form of symbiosis. These bacteria were found to have no nod genes, usually essential for nodulation. Bradyrhizobium...MIT, BU team builds viruses to combat harmful 'biofilms'
... be custom-designed to target different species or strains of bacteria. The work, reported in the July 3 Pr... different phages that target different species or strains of bacteria, each constructed using related design principles to express different enzymes. Creat...Rapid evolution of defense genes in plants may produce hybrid incompatibility
...of 900 first generation hybrid offspring among 293 strains of thale cress, Bomblies and Detlef found that 2% of the offspring were severely defective. They call this phenomenon hybrid necrosis or hybrid weakness, and identified the gene responsible for the incompatibility as a disease resistance gene that h......support the colony, so what's to keep more selfish strains of D. discoideum from cheating the system, avoidin... exacting studies of genetically engineered mutant strains conducted by former postdoctoral researcher Kevin Foster and postdoctoral researcher Natasha Mehdiab...