Studies find general mechanism of cellular aging
...a similar role in aging. The researchers developed strains of mice that were either deficient in p16INK4a (the gene was deleted, or 'knocked out") or genetically altered to have an excess of the protein to a degree seen in aging. According to Sharpless, islet proliferation persisted in p16INK4a -deficient a...Sequences reveal benign origin of deadly plant pathogens
...studies and for tracking the movement of different strains of P. ramorum. Further, this was the first case where researchers were able to infer gene function from actual evolutionary analyses based on the pipeline we have developed at http://PhIGs.org ." Professor Tyler added: "The sequences are a fundam...DOE JGI, VBI describe disease mechanisms of sudden oak death, related soybean pathogens
...ly different single-letter changes that vary among strains of the disease," said Jeffrey Boore, senior author of the Science study and DOE JGI Evolutionary Genomics Program head. "These 'fingerprints' are already being used to track the movement and identity of these species as they progressively invade dif...New anthrax inhibitor could combat antibiotic-resistant strains
...ibiotics, but the emergenceof antibiotic-resistant strains calls for new approaches to designingtherapeutics for bioterrorism agents, according to Ravi Kane, the MerckAssociate Professor of Chemical and Biological Engineering at Rensselaerand corresponding author of the PNAS paper. Pathogens such as anthrax ...University of Pittsburgh receives $1.3 million from NIH to develop promising avian flu vaccine
...will make it even more effective against different strains of the virus. Dr. Gambotto is hopeful that NIAID will be interested in comparing the effectiveness of his vaccine to that of two other vaccines that already have been tested in federally funded clinical trials. Those vaccines, produced by GlaxoSmit...Avian flu detection information on wild birds available
...ions of domestic and wild birds. Low-pathogenicity strains of avian influenza are commonly found in waterfowl and shorebirds; such strains do not cause significant disease in wild birds or in people. Many federal, tribal, and state agenc...... from the centre of the brain to form eyes. But in strains of fish that have no Rx3, no eyes develop and the cells remain inside the brain, because nothing tells them to migrate to the right place." In the embryo the paths for cell movements are signposted by cues that by attracting or repelling different ...Tight-knit family: Even microbes favor their own kin
...oward their relatives. The team collected wild strains of D. purpureum from the Houston Arboretum and too...ed in dishes. In each of 14 experiments, a pair of strains were placed in a dish in equal proportion, and one of the strains in each pair was labeled with a fl...Bird flu study highlights need to vaccinate flocks effectively
... of poultry flocks could make the spread of deadly strains of avian flu such as H5N1 worse, scientists at the Universities of Edinburgh and Warwick have found. The research shows that even though the available vaccines are effective on individual birds, the disease is likely to spread unless almost all of a ...Tips from the journals of the American Society for Microbiology
...nza outbreaks, and the threat of a pandemic as new strains continue to emerge and mutate, are of great worldw...st reliable method for identifying influenza virus strains takes 3 to 7 days and can only test a few samples simultaneously. In this blind study researchers...New hope for Hepatitis C research
...y, and how we can adapt treatment to the different strains of the disease." "Our research is still in the early stages, but the research model we have created will be a valuable toolin understanding the underlying mechanisms of chronic HCV infection, and how the virus responds tointerferon treatment" said ...Researchers devise new tools to help pinpoint treatments for heart failure
...ood position to do similar experiments with mutant strains of mice that experience heart failure in ways that mimic human disease." McCulloch is an expert at mathematical modeling the interactions of hundreds of enzymes and other molecules in heart cells. McCulloch and a team of Ph.D. candidates in bioengi......riety of experiments that included creating mutant strains unable to make outer-membrane cytochrome, or OMC, leading to an excess of uraninite particles forming only inside the cell, in the periplasm the region between the microbe's cell and outer membrane. In nonmutants, on the other hand, OMC and uraninit...Transgenic goat's milk offers hope for tackling children's intestinal disease
...hat were fed milk from non-transgenic goats. Some strains of E. coli can cause severe intestinal illness. However, the kid goats fed lysozyme-rich goat's milk, had higher levels of coliform bacteria and roughly the same level of E. coli, compared to control group. Both the kid goats and the young pigs ......ts an unrivalled capacity for new immune-resistant strains of African trypanosomes." Analysis of the genome sequence of T. brucei was published just last year, amid increasing calls for research into new control strategies for this neglected disease. The current study underscores this parasite's reputat...Innovative method for creating a human cytomegalovirus vaccine outlined
...ate selected elements from several human rotavirus strains into a bovine rotavirus backbone. The vaccine that resulted takes advantage of the immunological characteristics of both the human and bovine viruses. This approach is conceptually similar to Maul's strategy for developing a CMV vaccine, although the...Super blackcurrants with boosted vitamin C
...how it moves throughout the plant. Using different strains of blackcurrant plant the team can compare and analyse how the vitamin accumulates in the blackcurrant fruit as well as the limiting factors. To date the research has discovered that starch that accumulates after the berries have been harvested pl...UGA study explains peaks and troughs of dengue epidemics
...del applies to other regions where all four dengue strains circulate. The researchers compared the data with results from mathematical models that explore both independently and collectively the role factors such as temporary cross-immunity and variation in serotype virulence play in epidemics. They foun...Human behavior changes the number of strains of infectious diseases
...hat the coexistence of multiple infectious disease strains result from monogamous populations. "When people...e at a time), groups with different behavior favor strains with different properties," explain the authors. "When new interactions occur frequently, rapidly tr......the latest round is a project to sequence up to 50 strains of the yeast Saccharomyces cerevisiae. The genome of Saccharomyces cerevisiae was first completed in 1996 and is a primary model for studying variations in genomes that can contribute to health and disease. The genomic data provided by this effort wi...