Study finds gender differences in renal and other genes contributing to blood pressure
...red in a large community-based population with the strategy of assessing genetic variants of genes involved in two major blood pressure regulation pathways to identify gender differences in genetic contribution to blood pressure. The results reinforce previous observations of the role of gender in cardiovasc...Almac Diagnostics announces pioneering genetic research on ductal carcinoma in situ
...s curative in nearly all patients1. However, this strategy may represent over-treatment for those patients in whom disease will not recur2. A gene signature identifying the subset of DCIS patients most likely to suffer a DCIS recurrence, could therefore be used to aid those remaining patients who have been ...Unlocking proteins from their cellular shell
..., on, and around cells. Protein targeting is the strategy commonly employed to create new drugs to deal with those adverse affects. Cytoskeletal proteins, well-known amongst cell biology and biophysics researchers, are a leading cause of a large number of diseases that mess up proteins, sometimes misfold th...New strategy for treating allergic disorders
...c acid bacterium Lactococcus lactis might be a new strategy for treating various kinds of auto-immune and alle...lerance toward certain substances. This innovative strategy can now be developed further for the treatment of allergic and auto-immune disorders. The rising inc...Einstein researchers' prototype vaccine could provide improved protection against tuberculosis
...nse--lurk inside cells and multiply. A key evasion strategy involves preventing their host cells from undergoing apoptosisthe cell suicide often triggered when microbes invade cells. For intracellular TB bacteria, avoiding apoptosis is an understandable aim: Apoptosis flushes them into the open, activating im...Orangutans' communication resembles a game of 'charades'
...et their point across, they rely on the same basic strategy that people follow in playing the game of charades...ieved more quickly. The orangutans charades-like strategy is one way to construct a shared lexicon from learned or ritualized signals, the researchers conclud...Synchrotron could help save the Tassie devil
...e evident, he says. This would make any quarantine strategy easier to establish, as well as much more efficient. The idea is based on Australian research showing disease-related changes in the composition of human hair. The suggestion is that similar changes could occur in Tasmanian devils hair when the fac...Does EPA have an adequate strategy to oversee nanotechnologies?
...ronmental Protection Agency (EPA) have an adequate strategy to ensure that nanotechnology is being safely commercialized? Can it get needed information through a proposed program where companies voluntarily submit details about the nature of the nanomaterials they are using to manufacture products and about t...MIT model could predict cells' response to drugs
...ous end results. Lauffenburger compared a cell's strategy to playing a piano: Just as there are 88 keys that can be played in a vast number of combinations to produce different melodies, cells can use their multiple pathways together in many different combinations to produce different behaviors. One of th...JCI table of contents -- July 26, 2007
...age ABCA1 and ABCG1 expression may be an effective strategy to inhibit the development of, or reduce, atherosclerosis. TITLE: Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo AUTHOR CONTACT: Daniel J. Rader University of Pennsylvania, Philadelphia, Pe...'Preconditioning' helps protect brain's blood vessels from stroke
...ng helps minimize damage to heart tissue -- it's a strategy cardiologists routinely use today. And we know it can help protect brain cells -- neurons -- against stroke damage," Dr. Iadecola says. "Now, besides illuminating mechanisms involved in this process, our new study in mice demonstrates that preconditi...JCI table of contents: July 19, 2007
...therapeutic modulation of ERK1/2 could be a useful strategy during embryonic development for preventing this form of congenital heart disease. TITLE: Mediating ERK1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome AUTHOR CONTACT: Jeffrey Robbins Cincinnati Childrens Hospi...New proteomics research promises to revolutionize biomedical discovery
...complexes to concertedly exert their function. The strategy of the IRCM researchers was basically to identify the interaction partners of many proteins of well-known function, using sophisticated proteomics procedures and computational algorithms they developed. The initial guess of the scientists was that pr...Nature's secrets yield new adhesive material
...produce synthetic adhesives based on the adherence strategy of the gecko. What caught his eye in this article is gecko adhesion doesnt work well in water. Messersmith, who studies the underwater adhesion of mussels, had an idea. What if each synthetic gecko-inspired polymer, called a pillar, was coated wit...High blood pressure medication strategy proves effective in Hispanic women
...c white women who were randomly assigned to a drug strategy containing either a sustained release form of the calcium antagonist verapamil or the beta-blocker atenolol. The INVEST study enrolled more Hispanic patients than any other hypertension trial to date, Cooper-DeHoff said, and included Hispanic part......how how this particular, albeit important, therapy strategy may be optimized, but because they illustrate the more general potential for mathematical models to influence therapy decisions. “Our experience has been that clinicians and policy makers are often hesitant to consider, sometimes even hostile towards...One man's junk may be a genomic treasure
... repeated genomic sequences might be a widely used strategy used in mammals to organize functional domains. Without boundary elements, the coding portion of the genome is like a long, run-on sequence of words without punctuation, said Rosenfeld. Decoding the information written in junk DNA could open new...JCI table of contents: July 12, 2007
... talin and alpha-IIb beta 3 could be an attractive strategy for the development of future anti-thrombotic drugs, with a reduced risk of pathological bleeding. TITLE: The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIbIIIa) activation AUTHOR CONTA...New use for a cell toxin found to inhibit survival proteins in cancer cells
...ties to 2-Methoxy antimycin, Hockenbery said. This strategy has already yielded one additional Bcl-xL inhibitor with "gain of function" activity, reported in the Molecular Cancer Therapeutics paper. Funding for the study, 2-Methoxy antimycin reveals a unique mechanism for Bcl-xL inhibition, came from the New ...... up the equivalent switch in people might be a new strategy for treating overweight and obesity. The investigators said their next step is to rev up the control in mice and overfeed them to see if they are resistant to becoming obese. "Brown fat is present in mice and in human infants, where it keeps them w...