MIT creates 3-D images of living cell
...allized or otherwise processed to provide detailed structural information. When you fix the cells, you can't look at their movements, and when you add external contrast agents you can never be sure that you haven't somehow interfered with normal cellular function, said Badizadegan. The current resolution o...Abnormal fat metabolism underlies heart problems in diabetic patients
...housands of different lipids based on their subtle structural differences. The set of techniques has been termed "shotgun lipidomics" because they very rapidly determine which lipids are in tissues and blood. "Shotgun lipidomics provide a precise way to measure changes in heart lipid content," says first author...Research shows skeleton to be endocrine organ
...y bone-forming cells (osteoblasts), was not a mere structural protein, but rather a hormone with totally unanticipated and crucial functions. Osteocalcin directs the pancreas beta cells, which produce the bodys supply of insulin, to produce more insulin. At the same time, osteocalcin directs fat cells to releas...Weizmann Institute scientists discover a control mechanism for metastasis
...the anchor point on the cell membrane. Rather than structural support, this protein acts as a kind of plug, blocking the anchor point, and allowing the skeletal protein fibers to unravel into the threads that push the cells apart. The cell is then free to move, and, if its a cancer cell, to metastasize to a new...American Chemical Society's Weekly PressPac -- Aug. 1, 2007
...roperties have made it the worlds most widely used structural material. Concrete, however, is so porous that water soaks in, corroding steel reinforcing bars and meshes that strengthen concrete roads and buildings and causing cracks as water expands and contracts during freeze-thaw cycles. Sealants are commerci...Gene predicts better outcome as cortex normalizes in teens with ADHD
...with ADHD. Since this gene version had similar structural effects in healthy children as in children with the disorder, our findings suggest that ADHD is at the far end of a continuum of normal traits, said Philip Shaw, M.D., NIMH Child Psychiatry Branch, who led the research. ADHD likely stems from interac...In a first, Einstein scientists discover the dynamics of transcription in living mammalian cells
...eloped by Dr. Robert Singer, co-chair of anatomy & structural biology at Einstein and senior author of the study, which appears in the August issue of Nature Structural & Molecular Biology. The study focused on RNA polymerase II--the enzyme responsible for transcription. During transcription, growing numbers...Success or failure of antidepressant citalopram predicted by gene variation
...minated the need to compare all of the millions of structural units that comprise even a tiny segment of DNA a resource- and time-intensive process by organizing the units into more manageable blocks of information....New grants bolster efforts to generate faster and cheaper tools for DNA sequencing
...nformation. This would include information such as structural variations and aberrations associated with cancer genomes. The resulting data could be linked to information produced by other emerging sequencing platforms....New UD tissue-engineering research focuses on vocal cords
...rganization of natural extracellular matrices--the structural materials that serve as scaffolding for cells. These novel biomaterials, combined with defined biophysical cues and biological factors, are being used for functional tissue regeneration. Randall Duncan, associate professor of biological sciences an...Jan Lwe awarded 2007 EMBO Gold Medal
...cle and cell morphogenesis, through his insightful structural studies on virtually all of the key players, says ...n which had been discovered by Jeff Errington. The structural discoveries of FtsZ and MreB proved to be key pieces of evidence for the discovery of the bacterial ...20 Kentucky firms share $1.9 million from state to match federal SBIR-STTR awards
...fidelity modeling and simulation for aerodynamics, structural mechanics, and other applications. The Cabinet for Economic Development, through its Department of Commercialization and Innovation (DCI), is managing the program, which is being administered under contract to DCI by the Kentucky Science and Techn...Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
...sing X-ray diffuse scattering, the team quantified structural properties of different lipid bilayers seeded with FP-23 peptides. The lipid bilayers varied in their thicknesses, which affects the stiffness of cell membranes. The research was conducted at Cornell Universitys CHESS synchrotron, which provides a ...Researchers watch antibiotics, bacteria meet at atomic level
...human sick, the bacterium is widely used to gather structural information at the molecular level. The researchers first isolated the RNA polymerase from T. thermophilus. They then created an active elongation complex by mixing the enzyme with small molecules of DNA and RNA. This solution hardened into a cryst...Scientists discover new way to study nanostructures
...gs, which may be used to identify and characterize structural and mechanical properties of nanoparticles, including materials of biological interest, appear online in the journal Nature Nanotechnology. The AC Josephson effect refers to work that Brian Josephson published in 1962 regarding the flow of an elect...Steroids, not songs, spur growth of brain regions in sparrows
Neuroscientists are attempting to understand if structural changes in the brain are related to sensory experience or the performance of learned behavior, and now University of Washington researchers have found evidence that one species of songbird apparently has something in common with a few baseball slugge...Nicotine rush hinges on sugar in neurons
...led it a landmark accomplishment for the fields of structural biology and neuronal cell signaling. Besides substance addiction, Stevens pointed to epilepsy, schizophrenia and depression as targets for improved drugs that could result from the studys findings. The study provides the first detailed look at...... he designs to tackle problems in fields including structural genomics, systems biology, microbial ecology, and synthetic chemistry, are akin to having a fully automated laboratory on a postage stamp-sized wafer. Remember the early days of electronics with all of those big vacuum tubes and wires" Next came the ...JCI table of contents: July 19, 2007
...ed SHP2 had altered cardiomyocyte cell cycling and structural defects, while expression of the mutant protein in postnatal cardiomyocytes had no effect. Fetal expression of this mutated protein was found to activate the ERK1/2 pathway and further studies confirmed that activation by mutant SHP2 was necessary an...Crystal structure enables tailoring of pharmaceuticals against asthma
...lopments are membrane proteins. Until now detailed structural information on these proteins has been absent, and therefore it has been difficult to fully understand their function. The present study is likely to lead the way for the determination of structures of other human membrane proteins. The elucidation o...