Genetically modified parasite lets researchers probe immune system's memory
...ss of this minimal parasite remnant seemed in some studies to result in loss of immunity. For the new study, immunologists at the University of Pennsylvania infected mice with a genetically modified form of Leishmania created by microbiologists at Washington University School of Medicine. The modified Leishm...Gene for Joubert syndrom with excessive brain folds discovered by UCSD researchers and Harvard team
...rnal Nature Genetics.** Both the UCSD and Harvard studies were published online prior to the print publications in November. The AHI1 gene mutation is responsible for a form of Joubert Syndrome manifested by absence of part of the cerebellum, the part of the brain controlling balance, and by excessive ...International human genome sequencing consortium describes finished human genome sequence
...hers around the world to conduct even more precise studies of our genetic instruction book and how it influences health and disease." One of the central goals of the effort to analyze the human genome is the identification of all genes, which are generally defined as stretches of DNA that code for particul...DFG research training groups become increasingly international
...niversity of Leipzig. Their research will focus on studies of the retina as a visual organ as well as process... at the Humboldt University in Berlin. Whereas the studies into virology, bacteriology and parasitology are still highly focussed on their specific area, the a...For inferring the biological tree of life, simple is better
...ol for evolutionary biologists, largely because of studies that found it to be a more accurate and powerful t...nal work on phylogenetic methods with experimental studies to understand how genes evolve new functions. He is particularly interested in the evolution of hor...New DNA repair enzyme makes mistakes to save lives of cells
... more detailed biochemical analyses and structural studies to determine if our impressions are correct," said... at UPCI and the paper's first author. Additional studies also will provide researchers with more insight into POL-Q's role in preserving the integrity of the...New genomic method can identify disease-causing genes
...the power of the new computational technique. The studies are directed toward better understanding the genet...nce. This method eliminates the need for follow-up studies to mine large chromosomal regions, saving researchers from months to years of experimentation. In ad...Mouse study: 'Critical' Down syndrome region isn't
...report in the Oct. 22 issue of Science , based on studies in genetically engineered mice, shreds a 30-year-old notion that genes in this region are largely responsible for the condition's characteristic facial features and some of its other common traits. Down syndrome, which affects roughly 1 in 700 live b...Single genetic defect links many risk factors for heart disease and stroke
...as also an author on the paper. "Epidemiological studies over the last twenty years have shown that hypertension, high cholesterol, high triglycerides, low magnesium, diabetes, insulin resistance, and obesity tend to cluster with one another, but not in a simple way," said Lifton. "Not everybody who has an...NIH funds new bioinformatics resources at UT Southwestern
...arch, such as clinical trials, animal modeling and studies using cultured cells, allowing researchers to better identify altered genes and proteins that lead to disease. Dr. Scheuermann predicts that such a database will enhance the development of novel treatment strategies for diseases like autoimmunity. Re...Genetics play role in response to most common asthma drug
...E was developed based on observations from earlier studies that suggested that genetic differences in the beta-receptor might play an important role in how patients respond to albuterol. The BARGE study examined the effects of two forms of the beta-2 adrenergic receptor in patients with mild asthma. The tri...New method studies living bacterial cells
...lls. The new capabilities set the stage for future studies defining mineral-metal-microbe interactions in con...rocesses in extreme subsurface environments and to studies of a variety of astrobiology topics, such as detection of past or present life in samples returned f...Reductions in blood oxygen levels in newborns could contribute to ADHD development
...to 27 percent of all children. Data from previous studies suggests that diminished release of brain dopamine...e hallmark traits associated with ADHD. Previous studies in Dr. Decker's laboratory at Emory have shown that newborn rats who experience repetitive drops in ...Brain differences in adolescents, psychopaths, lend to their impulsive, risk-taking behavior
...ent than with how pleasurable it is. "These studies suggest that adolescent decisions may, in part, be due to a greater biological sensitivity to either rewards themselves or, more likely, the novelty of rewards," says Berns. "It is possible that a reward or novelty associated with the reward may trig......," Millonig says. Their next clue came from studies of mutant mice. Mice with a mutation in the ENGRAI...n autistic and control brains. "These studies not only reveal important changes in the neurotransmitter systems of autistic brains, but also the s...Early life stress harms mental function and immune system in later years
... Insight into one potential mechanism comes from studies showing how maternal care can induce alterations i...long after the stress has disappeared. Still other studies are unraveling the cellular basis for how early life stresses can lead to later cognitive impairment...Calorie restriction leads to some brain benefits but not others in mice
...ent or reverse these impairments." Though numerous studies have shown severe calorie restriction helps animal...ce did not. "For the last 20 years there have been studies that suggest free radicals, particularly superoxide, are involved in cumulative damage with aging an...Pesticides may promote Parkinson's disease and exercise may offer protection
...y Greenamyre, MD, PhD, of Emory University. "These studies on monkeys, therefore, support our previous findin... humans." The results also support epidemiological studies that suggest that chronic exposure to environmental toxins, such as pesticides, may contribute to th...OHSU scientists identify key gene that delays female puberty
... for Neuroscience meeting, Ojeda's group performed studies with rats showing that the TTF-1 gene is expressed...ntrol the onset of puberty. "While observational studies are required to determine the role of TTF-1 in humans, we know that children recently described to h......pulation analysis and to toxicology testing. These studies will also influence the development of curative treatment and regulatory decisions. "Before genetic mapping, we were able to expose a mouse to environmental toxins and see 'if' a disease developed, but with genetic information, we can also understand...