Time-lapse movies show brain cells move like a two-stroke engine
...idth of a hair over the course of an hour. The new study shows that a surprising mechanism underlies neuronal migration. The Rockefeller scientists suspected that the cytoskeleton, the scaffold of elements called microtubules that support a cell's three-dimensional shape, was important to neuron migration....Muscling in on a deadly cancer
...yosarcoma, "is a very mean childhood cancer," says study leader Mario Capecchi, co-chair of human genetics ...imilar to humans and thus are used as "models" for study of human diseases. Co-authors of the studies were University of Utah undergraduate Mark Hans...Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
...s well as a potential target for drug therapy. The study will be published in the Oct. 15 issue of the jour... NY, used transgenic (genetically altered) mice to study the biochemical pathways underlying muscle wasting. Their studies zeroed in on a transcription fact......r those with the bipolar form of depression, a new study finds. The discovery, which surprised researchers ...the brain known to be important to depression. The study relied on microarray analysis of 32 post-mortem brain samples -- the microarray method can simultane...NHGRI seeks next generation of sequencing technologies
...ation can be derived from those interactions. This study attempts to extend the use of nanopore sensors into living cells. Stuart Lindsay, Ph.D., Arizona State University, Tempe, Ariz. $550,000 (3 years) "Molecular Reading Head for Single-Molecule DNA Sequencing" Building on the concept of threading DNA th...Amphibians in dramatic decline; Up to 122 extinct since 1980
...ust a century, according to the most comprehensive study ever conducted. More than 500 scientists from over...environmental degradation." Key findings of the study include: According to the IUCN Red List of Threatened Species, at least 1,856 amphibian species ...Perceptual decision-making hub pinpointed in human brain
...e the researchers. Also participating in the study were Drs. Sean Marrett and Peter Bandettini, NIMH. ...How to use math and a CT scanner to see how trees intercept light
...ho have used a computed tomography (CT) scanner to study how tree branching affects light interception. "We collect CT scan data, which basically measures of density in 3D, to quantify the complexity of plant branching patterns," he explains. "This will lead to a more complete and accurate model providing ...Researchers find protein that makes long-term memory possible
...help to compensate for these problems." The study was conducted by NICHD's Petti Pang, Ph.D, and Bai...d tPA are needed to bring about L-LTP. "Our study has provided a link between these two seemingly unrelated molecule systems in L-LTP," Dr. Lu said. ...Study identifies target for preventing sexual transmission of HIV
...leveland, Ohio, and lead author on the paper. "Our study focuses on a strategy for preventing transmission of HIV through the vagina. We have identified a potential target, a mechanism critical for the transmission at vaginal sites of infection, that may offer a simple strategy for preventing HIV transmiss...Using fruitflies to examine alcohol tolerance
... that occur with repeated exposure to the drug. A study in the October issue of Alcoholism: Clinical & Ex... in flies." "The most provocative result in this study is the suggestion that rapid and chronic tolerance are mechanistically distinct," said Crabbe. "Thi...Identifying genes that contribute to a low level of response to alcohol
...eritability. Step three, he added, is the current study that seeks to identify those genes. Schuckit and his colleagues reviewed both animal and human English-language studies developed since January 1998, listed on Medline, and with appropriate keywords (n= 135). They then synthesized the studies' resu...Scientists explain how morphogens work
..., they can lead to organ defects and cancers. This study provides insights into the mechanisms of organogen... sought to determine how morphogens work. In a new study published in the October 15 issue of the journal Cell, Xinhua Lin, PhD, an assistant professor of de...Sniffing out the culprits of dust allergies
...ility to protect the receptor on whole cells. This study demonstrates the utility of this new approach for quickly identifying active proteases involved in allergic responses or other disease processes and effective inhibitors that can be further developed for diagnostic or therapeutic research. Nicolas W...Biological importance of basal activity of appetite suppressor
...ty of California, San Francisco, made a systematic study of naturally occurring MC4R mutations in obese patients. By genetically transferring normal or mutant versions of the MC4R gene into cells in culture, the authors were able to define a cluster of mutations at the N-terminal end that impaired the cons...S1P1 essential for tumor growth and is blocked by RNA interference
...promised and tumor growth suppressed in vivo. This study indicates both that S1P1 is vital for blood vessel growth in tumors and that RNA interference technology may be of great use in anticancer therapies. TITLE: Requirement for sphingosine 1phosphate receptor-1 in tumor angiogenesis demonstrated by in v...The long road to a promising malaria vaccine started at NYU School of Medicine
...ny of its victims are young children. In a study reported today of more than 2,000 children in Moza...ced milder forms of the disease by 30 percent. The study is published in the October 16, 2004, issue of The Lancet, a medical journal. "This is real...Normal cells in tumors may aid cancer growth
A study led by researchers at The Ohio State University Co...the clinical cancer genetics program. "But our study indicates that genetic damage occurs in stromal tumors cells, and that that damage may play an impor...Horse auction raises $75,000 for research
...rowing foals provide researchers an opportunity to study how nutrition affects metabolism and skeletal development. The research objectives are to develop pastures and pasture supplements that improve the reproductive efficiency of mares, optimize growth in the young horses, enhance athletic performance,......rgy output," said Vaisse, senior author on the new study and a scientist in the Diabetes Center at UCSF. "O...eaves in and out of the neuron's membrane. The new study reports six mutations -- in six different obese patients -- in the tail-like strip of the protein th...