deCODE discovers cause of major subtype of glaucoma
...pear to account for virtually all cases of a major subtype of glaucoma. The SNPs are located in the LOXL1 gene on chromosome 15, and confer respectively 26-fold and 8-fold increases in risk of exfoliation glaucoma compared to the low-risk versions of the same markers. Approximately 25% of those in the Icelan...'Supermap' of avian flu yields new info on source/spread
...ditional information. Clicking on a specific viral subtype generates a popup window revealing diagnostic mutations that distinguish one strain of the virus from another, and all of the data is linked to the National Institute of Health's GenBank. "The map gives us a whole new way of seeing the virus in ac...Migratory birds: Innocent scapegoats for the dispersal of the H5N1 virus
...persal. Highly pathogenic avian influenza virus subtype H5N1 was first detected in poultry in November 1996 in south-east China. The virus subsequently dispersed throughout most of Asia, and also to Africa and Europe. From mid-2005, migratory wild birds have been widely considered to be the primary source...Other highlights from the March 21 JNCI
...ne, known as MLH1, may have an increased risk of a subtype of colorectal cancer. Mismatch repair genes fix problems that arise during DNA replication when bases are incorrectly paired. Mutations in these repair genes are associated with increased risks of cancer. Stavroula Raptis and Miralem Mrkonjic, gr...Researchers begin 'Project 3000,' a recipe for hope through genetic research
...CA, doctors will be able to learn how each genetic subtype of LCA behaves over time and will be able to use t... as many individuals as possible with each genetic subtype so that clinical trials will never be slowed by a lack of affected individuals. Make genetic tes...Fighting influenza and co. with 40,000 blood samples
...reme virulence. The patho-gen, the influenza virus subtype A/H1N1, homed in on women and men in the prime of their lives. 'Normally respiratory diseases are dangerous for children and the over-60s,' the project coordinator Dr. Oliver Schildgen explains. 'What's more, in the case of the elderly the flu vaccin...Scientists identify pancreatic cancer stem cells
...hat define the highly aggressive pancreatic cancer subtype are not identically matched to those found in aggressive breast cancer, the researchers also discovered. The difference is in one marker, CD24, which is negative in breast cancer and positive in pancreatic cancer, according to Simeone. "These stud...Changes in amino acids in the 1918 influenza virus cut transmission
...hat of 1918, which was caused by a novel influenza subtype virus capable of causing severe respiratory disease and death," says Dr. Garca-Sastre. "So if we can understand the molecular mechanisms behind its transmission, perhaps we can do something to block transmission and prevent illness." To do this, Dr...Selective marker found to indicate aggressive form of breast cancer
...stic marker." The basal epithelial breast cancer subtype represents 17 to 37 percent of all breast cancers ...er demographic groups. Among breast cancers, this subtype is known to have an early age of onset and a very short time between treatment and relapse. It is mo...Evolution of influenza A virus
...nvestigate the evolutionary properties of the H3N2 subtype of human influenza A virus. The authors, in the first population-based study of its kind, collected a sample group of 413 complete influenza genomes from across New York State. Comparative analysis of the samples revealed genetically distinct viral...Getting to the heart of the heart
... in a Petri dish, then isolated a relatively rare subtype of cell (just 1 percent of the cells in the dish) that were poised to begin developing along a cardiac pathway. The presence of these cardiac progenitors was indicated by a green fluorescent protein, which lit up when a gene called Nkx2.5 was activat...U of S Vaccine and Infectious Disease Organization team discovers key step in flu virus replication
...all influenza viruses, including influenza A virus subtype H5N1," said VIDO Director Lorne Babiuk. Zhou says that although years of research remain to be done, this work provides novel insights for developing live vaccines and antiviral drugs for influenza epidemics and pandemics. A provisional patent has...Viral marker of human migration suspect
...eral instances of one population group harboring a subtype typically associated with another group," she said...ple one finds viruses from the Japanese and Korean subtype in the European subtype group--another incongruency." If the virus had been strictly passed down fr...Mature muscle fibers can revert to become cancerous, researchers find
...esearchers focused on alveolar rhabdomyosarcoma, a subtype of rhabdomyosarcoma, the sixth most common childhood cancer. Alveolar rhabdomyosarcoma is an aggressive, often fatal form of cancer that occurs primarily in the trunk, arms and legs of older children or teenagers. The disease starts when one of two...A new tool against brain disease
...ase," so a medicine designed to fit into a certain subtype of nicotinic receptor would produce more dopamine ...to begin to understand how to bind to one receptor subtype and not another" to trigger the release of whatever neurotransmitter is needed to treat or prevent a...Tips from the journals of the American Society for Microbiology
...solates and the correct type and partially correct subtype for 13% of the isolates. Incomplete subtyping in most cases was attributed to failure relating to nucleic acid amplification as opposed to testing limitations. "By using the FluChip-55 microarray in conjunction with a well-established RNA amplific...Breast stem cells have features similar to 'basal' tumors
...s of the stem cell resemble the aggressive 'basal' subtype of breast cancer. There is increasing evidence tha...rkers. These characteristics also define the basal subtype of breast cancer, which is more commonly seen in tumoursthat develop in women who are carriers of th...Gorilla susceptibility to Ebola virus: the cost of sociality
... humans and other great apes. Since 1994, the Zare subtype of the Ebola filovirus has been responsible for nine human outbreaks in Gabon and the Republic of the Congo; a majority of these outbreaks have originated from the handling of infected great-ape carcasses. In fact, Ebola virus has become one of the m...Genetic parallels found between lung development and lung cancer
...propriate treatment. In addition, cancers within a subtype may vary in their aggressiveness. Seeking a be...est prognosis. Even within a single adenocarcinoma subtype stage I disease survival times varied according to gene expression patterns. Gene expression patte...A broken stress response system can contribute to Gleevec resistance
...xtent with a drug called Gleevec (imatinib), and a subtype of ALL acute lymphoblastic leukemia, which does not respond well to this drug. The hallmark of both diseases is a genetic alteration in an enzyme (BCR-ABL) whose activity is specifically blocked by Gleevec treatment. The work reveals that loss of a ...