Tag: "subtypes" at biology news

Neuroblastoma expert reviews progress and challenges in fighting difficult pediatric cancer

...ns call a heterogeneous disease; its name includes subtypes of disease that behave very differently. Some cases strike in infants, but spontaneously disappear with minimal treatment, while other cases in older children may be relentlessly aggressive from the start. So precisely defining a given patient's risk...

Scripps research scientists show protein accelerates breast cancer progression in animal models

... Pleiotrophin stimulates new collagen of different subtypes and new elastin synthesis. Collagen fragments are known to stimulate growth of carcinoma cells and to stimulate anti-apoptotic pathways, favoring growth of the carcinoma cells. ...

Pediatric cancer stem cell identified: understanding the origin of ERMS

...f the cancerous cells, there are several different subtypes of RMS. Embryonal rhabdomyosarcoma (ERMS) is the most common subtype, usually found in children under 15, in the head and neck region and genitourinary tract. Dr. Zon and colleagues have developed an animal model to identify and test therapeutic ta...

Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells

...cute and chronic forms of leukemia, each with many subtypes that vary in their response to treatment. According to the National Cancer Institute, about 44,000 new leukemia cases will be diagnosed in the United States in 2007, and there will be about 22,000 leukemia-related deaths. Based on previous reports ...

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

... identify subsets of cell lines that represent the subtypes observed in analyses of primary tumors. By corr...ic agents should be prioritized for testing in the subtypes of breast cancer along with other cancers and their subtypes. When therapies are ineffective, they ...

Migratory birds: Innocent scapegoats for the dispersal of the H5N1 virus

...uring the previous epizooties of highly pathogenic subtypes of H5 and H7, it was shown that the expansion of t...and transmission of virulent agents, in particular subtypes of highly pathogenic influenza. Paradoxically, the H5N1 virus coupled with a fear of transmission by...

Lack of a protein in lung tumors may increase risk of death

...rn of silenced genes could distinguish between two subtypes of NSCLC, adenocarcinoma and squamous cell carcinoma. The research identified 47 genes that together can differentiate between the two lung cancer subtypes. It also found that the silencing of the Olig1 gene which results in the absence or low le...

Pacific Rim researchers to collaborate on distributed bioinformatics analysis of avian flu

...to annotate the biological structures of different subtypes of the avian influenza virus, at the same time as we study their variations," said principal investigator Peter Arzberger, director of Life Science Initiatives at UC San Diego. "We will also construct a grid infrastructure to support avian flu resear...

Grant to Yale from Simons Foundation to explore genetic causes of autism

...ny boys as girls. Researchers do not know how many subtypes of autism exist. Klin, the Harris Associate Profes... said the gene data might help identify meaningful subtypes of autism, thus advancing knowledge that is critical for behavioral and brain studies, and promoting...

Study advances evidence for receptor's role in alcohol pleasure and problems

... studies have shown that, among the brains various subtypes of opioid receptors, the mu-subtype is most likely responsible for transmitting alcohols positive effects. "We also know that there are several genetic variants of the human mu-opioid receptor," notes first author Christina Barr, V.M.D., Ph.D., a l...

Gene profiling predicts resistance to breast cancer drug Herceptin

...sities found markers that identified breast cancer subtypes resistant to Herceptin, the primary treatment for ...emonstrates that digging deeper into the molecular subtypes of these tumors helps us understand why some tumors are resistant and may point to ways to remedy th...

Researchers begin 'Project 3000,' a recipe for hope through genetic research

...cess to individuals affected with specific genetic subtypes of LCA. Even the most common genetic types of LCA occur in less than 300 people in the United States. Project 3000 seeks to identify as many individuals as possible with each genetic subtype so that clinical trials will never be slowed by a lack of a...

Changes in amino acids in the 1918 influenza virus cut transmission

...to initiation of infection. There are 16 different subtypes of hemagglutinin called H1 through H16, present in influenza virus strains circulating in birds. H1 and H3 are found today in human influenza viruses. Hemaglutinin helps open the door to the cell to allow the virus to infect. The first step is in ...

Selective marker found to indicate aggressive form of breast cancer

...wn that it is more likely than other breast cancer subtypes to respond to certain types of therapy, which highlights the need for a definitive diagnostic marker." The basal epithelial breast cancer subtype represents 17 to 37 percent of all breast cancers and is more common in premenopausal African American...

Silver bullet: UGA researchers use laser, nanotechnology to rapidly detect viruses

...a single virus particle and can also discern virus subtypes and those with mutations such as gene insertions and deletions. This specificity makes it valuable as a diagnostic tool, but also as a means for epidemiologists to track where viruses originate from and how they change as they move through population...

Three new lung tumor subtypes identified in DNA profiling study

CHAPEL HILL -- A new study has identified three subtypes of non-small-cell lung cancer tumors, a finding th... Hayes and his colleagues noted that the three new subtypes were robust and could be found frequently. All were identified in each of the data sets....

Viral marker of human migration suspect

...ause neurological disease. There are more than 14 subtypes of the virus, each primarily associated with diffe...with human migration, one would expect the various subtypes to group together geographically, she explains. Shackelton added that if the co-evolution of the v...

New drug blocks influenza, including bird flu virus

...) provided 100 percent protection against numerous subtypes (of flu), including the highly pathogenic H5N1 viruses...," according to the Journal of Virology report. The new drug, known as "entry blocker," is a fragment of a larger human protein whose role in biology is to help things pass through membranes s...

National Institutes of Health to map genomic changes of lung, brain and ovarian cancers

...ociated with cancer; and differentiation of cancer subtypes based on genomic changes. In addition, the pilot project will establish a publicly available integrated database that scientists can use to generate new knowledge through research. TCGA data will be made available through public databases supported...

New National Institute of Mental Health research program launches autism trials

...udies will define the characteristics of different subtypes of autism spectrum disorders (ASD) and explore pos...se autism. These studies seek to better define the subtypes within autism. Children with regressive autism appear to develop normal language and social skills b...

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(Date:7/28/2014)... team of researchers led by the University of Arizona ... The genetic information will enhance scientists, and agriculturalists, understanding ... as enable the development of new rice varieties that ... to help solve global hunger challenges. , The paper, ... ) and evidence for independent domestication," was published online ...
(Date:7/28/2014)... and organic compounds in hydrothermal environments are critical components ... for the deep biosphere, and may have implications for ... about how minerals influence organic reactions. A team ... a common mineral acts as a catalysts for specific ... solvents or expensive reagents. , At the heart of ...
(Date:7/28/2014)... Researchers at Yale School of Medicine have pinpointed a mechanism ... glucose levels in the blood, linking it to both type ... the July 28 issue of Proceedings of the National ... prolyl endopeptidase enzyme located in a part of the ... of steps in motion that control glucose levels in the ...
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