New class of tuberculosis-fighting antibiotics suggested by biochemical-pathway study
...e effect on the growth of TB in mice was small, it suggested that a valid target was identified. The research group went on to show that the enzyme disabled by the phenothiazines is called type II NADH dehydrogenase and is a unique and important antimicrobial target. "What we have now is a new target in TB,"...Gene variant increases risk of age-related macular degeneration
... percent of all cases of AMD. Earlier studies had suggested that CFH may play a role in protecting blood vessels from inflammation and damage, a function which might explain its role in AMD, the researchers said. "We knew that chronic inflammation played a role in macular degeneration, but we didn't know if ...Anti cancer virotherapy well tolerated in first human administration, research finds
...fren told conference delegates that these findings suggested that administration of a single dose of CVA21 directly into a cancerous tumour was well tolerated. "Administration of CVA21 may be of potential therapeutic benefit in controlling the spread of melanoma," Professor Shafren said. CVA21 is one of a smal...Childhood deficits in the cerebellum may be linked to adult alcoholism
...edical Center. "For example, imaging studies have suggested the involvement of the cerebellum in schizophrenia...ere have to my knowledge been no studies that have suggested a role for the cerebellum in alcohol dependence." Manzardo's research was prompted by a visiting H...Surprisingly complex behaviors appear to be 'hard-wired' in the primate brain
...lses that last less than a half-second. He further suggested that longer pulses might stimulate more complicated motions. Working with alert macaques, he and his colleagues found that applying such long-duration signals did in fact elicit several of these complex behaviors, much as they had predicted. Kaas and...Study finds anticonvulsant drug poses greater birth-defect risk than suspected
...sorders as bipolar disorder. Earlier studies have suggested a potential risk of birth defects, primarily neural tube defects such as spina bifida, but none had definitively established the level of risk and the types of malformations that most frequently occur. The North American AED Pregnancy Registry was e...Tiny scaffolding allows stem cells to become working fat cells
...uld develop type II diabetes," Kniss said. He also suggested that the new approach might have commercial applications as a way of testing new drugs. "Small, three-dimensional cell colonies could be grown on multi-well assay plates and be used to test dozens of compounds at the same time," he explained. "Since ...Emory scientists find new prostate cancer suppressor gene
... Xiaodong Sun, PhD. Although previous research has suggested that a section of chromosome 16 harbors a tumor suppressor gene in several types of human cancers, the particular gene responsible has not previously been identified. By studying the genes within the section of chromosome 16, the Emory scientists fo...Autism linked to mirror neuron dysfunction
...on and communication skills, previous research has suggested that a dysfunctional mirror neuron system may expl...earlier interventions. One therapeutic possibility suggested by the study's findings is biofeedback. Pineda, who also works on a number of brain-computer interf...Earth's services in peril, report concludes
...scientific community is offering an evaluation and suggested options. Now is a real opportunity for leadership." The study said that three key changes must take place before major change is realistic. People must first understand that the services provided by nature are not free and limitless. Local communit...Aspirin is safer than warfarin and just as effective for treating blocked arteries in the brain
...much as 15 percent per year. Studies in the 1950s suggested that anticoagulants (a class of drugs that reduce blood clotting), such as warfarin, can reduce the risk of stroke in people with this disease. In the new study, called the Warfarin Aspirin Symptomatic Intracranial Disease (WASID) trial, investigator...Research breakthrough in the understanding of the spread of cholera
...e University of Haifa team, led by Prof Meir Broza suggested that egg masses of non biting midges serve as a natural reservoir of cholera. It was discovered quite 'accidentally'. Broza explains: "We were looking for a safe way to control nuisance midges in an Israeli drinking water system. One day hundreds of...Ingredient in garlic protects against severe chronic pulmonary hypertension in rats
...ght to have medicinal properties, and reports have suggested that garlic supplementation in humans could help l...ion and enhance thrombolysis. Garlic also has been suggested to improve arterial oxygenation associated with pulmonary dysfunction in patients with hepatopulmona...Estrogen, SERMS reduce asthma impact by halting constriction
...ego (April 3, 2005) For years, anecdotal evidence suggested that ovulating or pregnant women or post-menopausal women taking estrogen supplements, experienced fewer asthma attacks and less severe asthma symptoms, strongly suggesting that perhaps estrogen affects airway smooth muscle function by preventing the...Society of Nuclear Medicine offers program to meet patients' current, future needs for radionuclides
...uclide Production Enhancement (NRPE) program. This suggested program, which addresses the current and projected future shortfalls of radionuclides in this country, has gained the support of numerous professional organizations. They include the Academy of Molecular Imaging, the Academy of Radiology Research, th...Yeast discovery gives insight into familial dysautonomia
... in cell growth and found several indications that suggested that the protein the Elp1 gene codes for -- called Elp1p -- plays an important role in directing cell polarity. Previous research results have identified Elp1p as playing a different role -- that of gene expression, an activity that occurs in the nuc...SSRI antidepressants involve dopamine as well as serotonin signaling
... of treatment before antianxiety effects are seen, suggested the researchers. Also, they wrote that their findings may explain why treatment of children with fluoxetine can induce depressive symptoms in adulthood. The researchers wrote that, since serotonin plays a vital role in neuronal development, disruptio...Mouse with designer liver has enhanced glucose tolerance and improved insulin response
...lls. Biochemical studies on Gab1 in cell cultures suggested that Gab1 is also involved in insulin signaling, but it is not clear how Gab1 acts to control insulin activity in the liver. To learn how Gab1 functions in the liver, Feng used a highly advanced genetic engineering technology, called tissue-specifi...Unconventional brain circuits offer clues to insomnia-obesity connection
...of this apparent insomnia-obesity association have suggested a causal link between the two, but the underlying mechanism has remained unclear. The new findings of hypocretin neurons offer some possible clues, Horvath said. Scientists discovered hypocretin neurons while studying narcolepsy, a condition marked b...Jeffrey Friedman, discoverer of leptin, receives Gairdner, Passano awards
... reframed views on the pathogenesis of obesity and suggested that the development of approaches to improve leptin response in resistant individuals could provide new treatments for obesity. Leptin itself has proven to be an effective therapy for a number of other human conditions associated with low leptin le...