Amgen investigational therapy, AMG 162, increased bone mineral density with twice yearly injection
...l cohort comparison to FOSAMAX®. "This study suggests that AMG 162 significantly improves bone mineral density in postmenopausal patients experiencing bone loss," said Michael McClung, MD, FACE, principal investigator of the AMG 162 study and founding director of the Oregon Osteoporosis Center in Portla...Columbia University scientist wins 2004 Nobel Prize
...arine snail, and molecular analysis of these genes suggests how diverse behavioral patterns may be encoded in the genetic material and inherited from parent to offspring. ...Fungus knocks a frog down but not out, raising questions about amphibian declines
...te a high rate of infection in that species. This suggests that some species may tolerate the pathogen, which raises questions about how the disease persists and spreads from frog to frog and region to region. "T. eungellensis seems to have been 'lucky' in terms of having at least survived the fun...Researchers find chemosignal that encourages women's sexual desire
...on," McClintock explained. Other research suggests that women living in early societies produced children when food resources were plentiful. The chemosignal would have been a way of encouraging other women to reproduce when circumstances were optimal. In 1998, McClintock and other resea...Muscle-building hand-grips aid systolic blood pressure, carotid AD, endothelial function
...fore training, the artery still dilated more. This suggests a heightened vasoactive sensitivity to the reactive hyperemic stimulus. These findings suggest that the reduction of blood pressure with IHG may be due to improvements of endothelial function....Is more better: Counting birds may only tell part of the story
...aintained an open habitat and abundant prey. This suggests some birds are able to adjust to changes, seizing the "ecological opportunities" that may arise from human disturbances and learning to avoid ecological traps. For a global understanding of these results, Bock and Jones suggest that studies o...Protein protecting brain from toxins also blocks some chemotherapy from reaching tumors
...he cerebrospinal fluid (CSF). The finding strongly suggests that the natural role of Mrp4 is to block the pass...l for this type of transporter," Schuetz said. "It suggests that Mrp4 blocks specific molecules from leaving the capillaries. And if such molecules slip out of ...'Junk' DNA may be very valuable to embryos
...lished in the October issue of Developmental Cell, suggests that retrotransposons may not be just the "junk DNA" once thought, but rather appear to be a large repository of start sites for initiating gene expression. Therefore, more than one third of the mouse and human genomes, previously thought to be non-f...Environmental exposures before and after birth can harm children's lungs
...s 12 and 24 months. "A great deal of new evidence suggests that the respiratory system may be vulnerable to damage caused by inhaled environmental agents during the prenatal period," said Rachel L. Miller, MD, the study's lead author at the Columbia Center for Children's Environmental Health, part of the Col...Acoustics meeting in San Diego
...ngstanding misconceptions in sports. New research suggests that the spot on a baseball bat that feels the best to a hitter (i.e., transmits the least vibration to the hands) may not really be the spot that can send the ball the farthest distance. Dan Russell of Kettering University in Michigan ( drussell@ke...Mitochondria findings may help beat wide range of disease
...ssary for healthy cell physiology. Recent research suggests that when this process goes awry, healthy cells die, resulting in diseases ranging from optic atrophy (the most common inherited form of blindness), to Charcot-Marie-Tooth disease (a disease in which nerves in the hands, feet and lower legs die off),...Rutgers-led research offers new clues in the genetic mysteries of maize
...l genes, a common practice in genetic engineering, suggests that it would create an unnatural instability in the genome," said Messing. "With all the maize genes moving around by themselves in nature, perhaps conveying some selective advantage in doing so, this argument is unfounded." Through sophisticated co...Estrogen protects male rats from aortic aneurysms
... "Dr. Woodrum's study extends earlier research and suggests that there also is something inherent in males tha...ly 17 percent of the female aortas in female rats, suggests that host environment is the critical factor in aneurysm formation," Upchurch says. In the third par...Channel protein converts vibrations to electrical signal
...the cilia within minutes. According to Corey, this suggests that once a hair cell senses that its signaling co...el in the hair cells, the structure of the protein suggests that it may play another role. Previous biophysical studies had indicated that a springy structure t...Gladstone researchers resolve key Huntington's disease mystery in Nature cover story
...and thus prolonging neurons' survival. The finding suggests that mutant huntingtin protein inflicts its damage in some form other than as inclusion bodies, which are insoluble, or resistant to being dissolved in liquid. Investigators may now focus attention on the possibility that the real culprit is a more s...Study using robotic microscope shows how mutant Huntington's protein affects neurons
...treatments for HD and other disorders. This study suggests that finding ways to remove mutant proteins diffused throughout the cell might be a more effective approach. "This approach provides a way to connect cellular changes to fate," says Dr. Finkbeiner. The automated microscope system could be app...Tips from the Journals of the American Society for Microbiology
...vaccine Research from Sweden suggests that adding the drug tucaresol to plasmid DNA influenza vaccines could offer longer-lasting and more efficient protection against the influenza virus. The findings appear in the October 2004 issue of the Journal of Virology. An...Experimental drug prevents vaginal simian HIV transmission in monkeys Science study says
...ss of PSC-RANTES against SHIV in these experiments suggests that CCR5-inhibition -- alone or coupled with other approaches -- might prevent sexual HIV transmission between humans, according to the authors. The majority of HIV infections are acquired via transmission across mucosal surfaces, especially the va...Muscling in on a deadly cancer
...mice have some characteristics of stem cells. That suggests the "primitive-appearing [rhabdomyosarcoma] tumors may be the result of non-primitive [muscle] cells reverting to a primitive state," Keller says. Mice with rhabdomyosarcoma now can be studied to determine how the cancer arises f...Mechanism discovered for muscle wasting seen in diabetes, AIDS and other diseases
...ockage of the NF-kB pathway can ameliorate atrophy suggests a new set of drug targets for chemical intervention during cachexia, cancer, AIDS and other settings of atrophy," the authors conclude. "This is critically important because unfortunately there are currently no drugs approved for the treatment of sk...