Growth of common skin cancer blocked in gene-switch mice
... that this does not happen in regressed mouse BCCs suggests that any residual human BCC cells, if present, should also remain in check as long as the Hh pathway is effectively inhibited....Mouse brain tumors mimic those in human genetic disorder
... system cells occurs before actual tumor formation suggests that these events are important for the development of tumors," Gutmann says. "These findings raise the possibility that targeted therapies for NF1 brain tumors may involve agents that prevent the supply of growth promoting factors provided by new bl...Brain tumor study reveals why treatment efforts fail in genetic disorder
...n the Jan. 1 issue of the journal Cancer Research, suggests where researchers should now look for more promising approaches to treating neurofibromatosis tumors, and may help scientists understand other cancers related to RAS. "The downside is our study proves we're not using the right therapies for this part...Fox Chase Cancer Center scientists discover key proteins linked to aging and cancer
...n of this cancer, but no one knew why. Adams' work suggests the possibility that this cancer arises because PML is unable to do its job in forming SAHF. If so, then extrapolating from recent findings in other cancers, inactivation of PML, HIRA, ASF1a and formation of SAHF may also contribute to other human c...A key signaling molecule in osteoarthritis is identified
...by degrading major matrix components. "Our study suggests that collagen binds to DDR2 and stimulates the production of an enzyme, MMP-13, that in turn degrades the cartilage," concludes Dr. Li. "Our study also identifies a signaling pathway in cartilage cells used by DDR2 to regulate the synthesis of MMP-13...Winter biological processes may help spread shrubs in the Arctic
...05 issue of BioScience, a variety of evidence now suggests that winter biological processes form a positive feedback mechanism that is contributing to the expansion of shrubs in the Arctic. The effect could have important implications for the global carbon budget, as the mechanism may liberate large stores o...Human complexity and diversity spring from a surprisingly few (relatively speaking) genes
... RNA editing in malignant brain-tumor tissue. This suggests that epileptic seizures in patients with brain tumors could be caused by an editing deficiency with regard to the channel molecule." Maas's research group recently discovered that A-to-I editing, in which adenosine is converted to inosine, is widespr...Higher blood pressures among African Americans - genes not likely to be an explanation
...fferent interpretation to the previous US data and suggests that high rates of hypertension might have more to do with lifestyle and socio-economic background than with racial origin. Previous studies in the US, and to a lesser extent the UK, have shown that populations of African descent are much more likely...Study examines relationship of vitamin A pathway to breast tumor progression
...es the role of retinoids in normal development and suggests future research strategies to determine how retinoids may prevent tumor formation and growth of both hormone receptorpositive and negative breast cancers.......ansit patients benefited from fiber. Further data suggests that while many patients may be helped by a fiber-...ed doses. With this information, Dr. Mller-Lissner suggests that "patients may no longer be bothered by ineffective advice regarding fiber and fluid ingestion n...Pitt scientists study how cancer cells get out of control
... spindles were no longer multipolar. "This finding suggests that a possible treatment for some types of cancer could be a drug that inhibits NuMA," noted coauthor Susanne M. Gollin, professor of human genetics in Pitt's Graduate School of Public Health and coinvestigator at the Oral Cancer Center of Discovery...Scientists decipher genome of bacterium that helps clean up major groundwater pollutants
...udy the evolution of catabolic pathways. The study suggests that the microbe may have developed the metabolic capability to consume chlorinated solvents fairly recently possibly by acquiring genes in an adaptation related to the increasing prevalence of the pollutants. As evidence, they point out that about ...Don't count on vitamin C to boost your exercise performance
... in antioxidant defenses, or both. Recent evidence suggests that increased ROS tonically suppresses myocardial beta-adrenergic receptor responsiveness in middle-aged and older adult humans, as this can be reversed by acute intra-coronary administration of the powerful antioxidant ascorbic acid." However in th...Scientists discover key genetic factor in determining HIV/AIDS risk
...ion and disease onset. In a broader sense, it also suggests how the immune systems of individuals with different geographical ancestries might have evolved in response to microbial stresses and how these differences in the immune system might result in medical approaches to thwart HIV/AIDS or other infections...National Academy news: Water quality improvement in southwestern Pennsylvania
...nse Plan" (CWARP) to deal with these problems, and suggests ways to better unify and coordinate the region's e...ndards even in dry weather, the report adds, which suggests contamination from failing septic systems. Livestock management practices in rural areas are likely...Scientists discover unique microbe in California's largest lake
...e of this hybrid gene over such a long time period suggests that it has been favored by natural selection," Miller says. The foreign DNA encodes a structural feature of the ribosome that makes large and precise movements during protein synthesis, but its exact function is still unknown. The next challenge, Mi...Mutations in transporter protein shed light on neurodegenerative disorders
... reduction in sialic acid transport activity. This suggests that for the milder form of the disease increasing the level of expression or stability of the protein could be one way to treat the disease," concludes Dr. Reimer....Queen's discovery sheds new light on ancient temperatures
...scovery by a team of Queen's University scientists suggests that ancient earth was much colder than previously...al theory known as "The Snowball Earth" hypothesis suggests that around 700 million years ago the earth was almost totally enclosed in ice. The Queen's discover...An invasion of cheats: The evolution of worthless nuptial gifts
...asion of so-called male cheating behaviour, and it suggests that the evolution of worthless gift-giving may arise though males' sensory exploitation of female preferences for nutritious gifts. Natasha R. LeBas and Leon R. Hockham: "An Invasion of Cheats: The Evolution of Worthless Nuptial Gifts"...Healthy cleavage: How statins protect against Alzheimer disease
...known, but a study by Sam Gandy and colleagues now suggests a possible mechanism. Alzheimer disease is characterized by accumulation of amyloid deposits in the brain. These deposits are composed of amyloid-beta (A b ) peptide, a protein fragment that is cleaved off from the amyloid precursor protein APP. AP...