Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations
...igger cancer and/or inactivate genes that normally suppress cancer. However, they emphasize that far more work remains to be done to clarify the relationship between cancer and the breakage hotspots. One thing researchers have determined is that the regions immediately flanking the breakage hotspots contain m...Researchers identify gene's role in suppressing longevity
...that, unlike in yeast, mouse SIRT1 can function to suppress cellular longevity rather than to promote it," said Alt. "That has been a big surprise to the field since it does not fit with preconceived notions of the role of SIRT1." In further studies, the researchers found that SIRT1 might regulate senescence ...GSK nonpeptide oxytocin receptor antagonists damp contractions in late-term rat pregnancy
...t spontaneous myometrial contractions in vitro and suppress myometrial activity in live animal models. In a cl...in anesthetized rats. Furthermore, these compounds suppress spontaneous contractions in late-term (19-21 days) pregnant rats." Brooks is speaking at the Ameri...Elevated temperature enhances success of viral cancer therapy
... not advocate the use of pharmacological agents to suppress fever would favor the tumor-selective replication of ONYX-015. This study indicates that induction of a heat shock response by pharmacological agents (that could potentially be administered systemically) or local hyperthermia, could greatly augment a......p between PTEN and TSC2 in tumorigenesis: TSC2 can suppress formation of specific tumors caused by Pten heterozygosity, but PTEN is haploinsufficient for repression of carcinogenesis resulting from Tsc2 heterozygosity. Specifically in the kidney, the researchers determined that Tsc2-heterozygous tumors need t...Researchers find potential Celebrex target in lung cancer
...roduced by lung cancer tumors fuels the cells that suppress immune function in patients and may be a target fo...ty of lymphocytes called T-regulatory cells, which suppress immune function, making it even harder for a patient to fight cancer. For the first time, UCLA resea...Retina adapts to seek the unexpected, ignore the commonplace
...ly rare horizontal features, the retina adjusts to suppress the routine vertical features while highlighting the singular horizontal elements. Meister and his co-authors examined neural signals in retinal ganglion cells, which convey visual images from the eye to the brain. These cells generally record local ...Gene changes linked to deficient immune suppression in MS
...changes reflecting a drop in the body's ability to suppress inflammatory cells that attack nerve fibers and promote progression of multiple sclerosis. In a study published in the July issue of the Journal of Neuroscience Research, OHSU scientists, in collaboration with The Immune Response Corp. of Carlsbad, ......ormation? How does it generate signals or receive, suppress or transmit signals from the environment? How does this manifold collection of molecules result in life? To find answers to such questions, scientists today are trying to understand these life processes as a whole as a system. However, this endeavor...'Vicious cycle' of protein formation involved in Parkinson's disease
...t when the system goes out of balance, the fibrils suppress the normally functioning enzyme, preventing it from fully breaking down the unfolded alpha-synuclein, resulting in even more of the protein being available to form clumps. The clumps also alter the structure of the enzyme in such a way that it produc...Tiny zebrafish teaches researchers how to fight off a deadly cancer
...astatic melanoma cells provide molecular cues that suppress tumor development. Hendrix is president and scie...that is, the zebrafish microenvironment appears to suppress the tumor-forming abilities of malignant melanoma cells. "The significance of this study is the po...NIH awards $11.9 M to The Burnham Institute to establish the San Diego Chemical Screening Center
...acterial toxins, radioprotective drugs, drugs that suppress inflammation and autoimmunity for diseases including rheumatoid arthritis, lupus, multiple sclerosis, and inflammatory bowel disease, drugs for behavioral diseases including attention deficit disorder, substance abuse, schizophrenia, and bipolar dise...Other highlights in the June 15 JNCI
...of its ability to catalyze free radical formation, suppress the immune system, and fuel the growth of cancer cells. However, studies in humans that have examined the role of iron on the risk of developing colorectal cancer have had conflicting results, which may in part be the result of using different metho...Monkeying around to improve organ transplantation
... first time that anergic T cells generated ex vivo suppress renal allograft rejection in non-human primates. This may be an approach that could be used in human transplant trials....New advances may slow tumor growth in pancreatic cancer
...ancer that inactivate pathways that would normally suppress cell growth. Published in the June 10 issue of the Journal of Biological Chemistry, the study was led by Dr. Murray Korc, a pioneer in early research on growth factor receptors in pancreatic cancer, and chair of the department of medicine at Dartmout...JCI table of contents July 1, 2005
... first time that anergic T cells generated ex vivo suppress renal allograft rejection in non-human primates. This may be an approach that could be used in human transplant trials. Title: Renal allograft rejection is prevented by adoptive transfer of anergic T cells in non-human primates AUTHOR CONTACT: Hisa...Plant pathologists explore using fungi to control plant diseases
...ch indicates that some of these benefits may be to suppress plant diseases and other stresses," he said. Plant pathologists have found that introducing non-harmful endophytes to a plant can cause it to become more resistant to plant diseases that may harm or kill the plant. When an endophyte is introduced in...Raisins as a functional food for oral health
...wed that phytochemicals in this popular snack food suppress the growth of several species of oral bacteria associated with caries and gum disease," said Christine D. Wu, Professor and Associate Dean for Research at the University of Illinois at Chicago College of Dentistry and lead author of the study. Routin...Suppressing growth hormone in early adulthood may prevent cancer
... the somatostatin class are currently available to suppress growth hormone and IGF-1 in people, so somatostatin analogs could be given as preventative measures to lower plasma IGF-1 before the onset of disease, especially in high-risk people. In a previous study, rats with high levels of growth hormone (a cir......e from drugs given to organ transplant patients to suppress the immune system, to treatments for high blood pressure and heart disease. Pessah's research group works with calcium channel modulators and other biomolecules derived from plants and scorpion venom. But when Pessah and Molinski got to talking at a ...