JCI table of contents: March 15, 2007
...d, largely because tumors develop ways in which to suppress the immune system. For example, before immune cells known as CD8+ T cells can destroy tumors cells they must receive signals through 2 receptors on their cell surface and many tumors do not express the molecules that trigger the second signal, throug...Making memories that last a lifetime
...y controlled the activity of genes known to either suppress or promote memory formation. The memory suppressor gene they studied is called protein phosphatase 1, and the memory-promoting gene is called reelin. "To our knowledge, this study is the first to present evidence that DNA methylation, once thought ...Green tea and COX-2 inhibitors combine to slow growth of prostate cancer
...ke celecoxib (known under the brand name Celebrex) suppress prostate cancer in animal models. COX-2 inhibitors also have been shown to cause adverse cardiovascular effects when administered at high doses over long durations. In 2004, Mukhtar and his colleagues demonstrated that green tea polyphenol EGCG h...Other highlights in the Feb. 21 JNCI
...authors write. Finally, the finding that KISS1 can suppress metastasis in the apparent absence of GPR54 in tumor cells opens up the possibility that additional KISS1 metastasis suppressor receptors and signaling pathways exist with the potential to be selectively targeted. Contact: Hank Black, UAB Media Re...Neuroscientist Robert Sapolsky will discuss stress, health, Feb. 17 at AAAS meeting
...dren, the continual release of glucocorticoids can suppress the secretion of normal growth hormones. "There's actually a syndrome called stress dwarfism in kids who are so psychologically stressed that growth is markedly impaired," Sapolsky said. Studies show that long-term stress also suppresses the immune...UCI awarded $3.5 million for stem cell research
...ting them into a patient often requires doctors to suppress a patients immune system. Currently, transplanting multipotent stem cells into the injured central nervous system often results in poor cell survival. The second round of CIRM research funding up to $80 million over four years is scheduled to be ...New study may show how to forestall a fatal, virus-caused immune-system meltdown
...gnaling pathways well enough, you can stimulate or suppress the immune response in the right way at the right time to create safe and effective therapies. According to Bowick, the Pichinde experiments have already generated some therapeutic leads, thanks to the unexpected discovery that a growth factor rece...New role in asthma for old drug
...fore indicates that targeting DCs in the lungs can suppress allergic asthma in mice and might lead to studies determining whether such targeting by iloprost can provide a new treatment for individuals with asthma. ...JCI table of contents: Feb. 1, 2007
...fore indicates that targeting DCs in the lungs can suppress allergic asthma in mice and might lead to studies determining whether such targeting by iloprost can provide a new treatment for individuals with asthma. TITLE: Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway den...JCI table of contents: January 25, 2006
...h MS. TITLE: Heme oxygenase1 and carbon monoxide suppress autoimmune neuroinflammation AUTHOR CONTACT: Miguel P. Soares Instituto Gulbenkian de Cincia, Oeiras, Portugal. Phone: +351-214464520; Fax: +351-214407970; E-mail: mpsoares@igc.gulbenkian.pt . View the PDF of this article at: https://www.the-jc...Reactivated gene shrinks tumors
...ancers arise due to defects in genes that normally suppress tumor growth. Now, for the first time, MIT researchers have shown that re-activating one of those genes in mice can cause tumors to shrink or disappear. The study offers evidence that the tumor suppressor gene p53 is a promising target for human c...Small molecule offers big hope against cancer
...er cells," Michelakis said. "Cancer cells actively suppress their mitochondria, which alters their metabolism,...erent forms of cancer, because all forms of cancer suppress mitochondrial function; in fact, this is why most cancers can be detected by tests like PET (positro...Antibody therapy prevents type 1 diabetes in mice
... have demonstrated that CD137 antibody therapy can suppress the development of type 1 diabetes in mice and that the effect is dependent on the induction of a certain subset of regulatory T-cells. If we can demonstrate this same genetic predisposition and therapeutic effect in human type 1 diabetes patients, t...New HIV test may predict drug resistance
... During antiretroviral therapy that does not fully suppress the virus, a strain that develops drug resistance will grow more quickly than strains lacking such resistance, and the resistant strain will replicate to become the most prominent virus in the person's body. "The viral populations found in the blood......roach has been to use broad strokes," he says. "We suppress the whole compliment of genes involved in memory formation rather than chasing each individual gene and its expression." The rat results are then compared with the information gleaned from the memory imaging in humans to see if there's a correlatio...Pair of microRNA molecules controls major oncogene in most common leukemia
... of two miRNAs known as miR-29 and miR-181 seem to suppress expression of the TCL1 oncogene that drives the most aggressive forms of the leukemia, said the studys lead author, Yuri Pekarsky, Ph.D., assistant professor in the Department of Molecular Virology, Immunology and Medical Genetics at Ohio State Unive...Researchers create genetically matched embryonic stem cells for transplantation
...d tissues formed, with no rejection and no need to suppress the recipients' immune system. Daley's laboratory at Children's Hospital Boston is now trying to replicate its results with human eggs. As Daley noted, there are several potential limitations to embryonic stem cells generated by parthenogenesis. Fi...Burnham Institute for Medical Research announces affiliation with UC Santa Barbara
...ly target drugs to tumor blood vessels in mice and suppress the growth of those tumors. He has also found a way to selectively target the lymphatic vessels in tumors. The hope is that this very specific delivery of therapeutics to tumor blood and lymphatic vessels will increase the efficacy of cancer therapie...Preventing graft-versus-host disease disease after bone marrow transplant -- without toxicity
...ike other treatments to prevent GVHD, BPI does not suppress the immune system and has shown virtually no toxicity. Researchers Ofer Levy, MD, PhD, of Childrens Hospital Boston, and Eva Guinan, MD, of Childrens Hospital Boston and Dana-Farber Cancer Institute, will present their most recent findings and dis......ough the soluble factor TGF-beta has been shown to suppress the growth of tumor cells in the early stages of breast cancer, high levels of TGF-beta during the later stages of the disease are associated with a poor outcome. A study using human breast cancer samples and mice, which appears online on December 7 ...