UVA studies potential target for skin cancer treatment
...ccine to stimulate the immune system to attack and suppress melanoma tumors. "Scientists are beginning to see patterns in the profile of genes expressed in individual tumor cells," said John C. Herr, Ph.D., professor of cell biology at UVa and a scientist at the UVa Cancer Center. " Patients who express a g...Researchers receive $12.8 million NIH grant to improve diagnosis/treatment of chronic lung disease
... T cells, also known as the "the gatekeepers," can suppress allergic responses and control allergies in humans. The ability of these cells to control allergic responses may be critical in determining which patients develop allergy and which patients do not develop lung damage. "Our ultimate goal is to lear...JCI table of contents: Oct. 2, 2006
...Italy, have identified one pathway by which tumors suppress the anti-tumor response, providing new avenues of ...uppressor cells (MSCs) because of their ability to suppress an immune response. Vincenzo Bronte and colleagues have now shown that MSCs marked by their expressi...Recycled paper and compost could both be key tools to control plant disease
... compost contains a diversity of microbes that can suppress plant diseases. The ecological benefits of this are obvious: less fungicide has to be applied to plants, less peat is required thus preserving peat bogs, and green waste and paper waste that would otherwise be land-filled is recycled. Professor Ra...Heavy drinking can hasten the progression of the simian immunodeficiency virus disease
...clear. "Each episode of alcohol intoxication can suppress multiple elements of immune function in humans," he said. "This suppression can be largely responsible for the increased incidence of infections such as pneumonia. However, chronic alcohol consumption can also stimulate the immune system, leadin...A spicy solution for colon cancer?
...f colorectal cancer cells, and that curcumin could suppress this migration -- possibly reducing the ability of colorectal cancer to spread to other locations in the body. "Our findings suggest that curcumin may be useful for colon cancer treatment, as well as potential colon cancer suppression, in cells that...Search for natural, safe and abundant chelator may be a 'shell game'
...ionuclides, scientists speculate that chitosan may suppress deposition in bones and critical organs like the liver and kidney, and accelerate removal from the body. Levitskaia's research is directed toward finding a natural chelator like chitosan that can safely and effectively rid the body of diverse radionu...Mechanism to organize nervous system conserved in evolution
...high levels of BMPs in non-neural regions actively suppress neural development. This role of BMPs is one of the best examples of a conserved evolutionary process. However, it has been less clear whether BMPs also play a common role in further subdividing the nerve tissue into three distinct regions. Althoug...Fight weeds with plant pathogens
...anaging weeds. "The use of plant pathogens to suppress weeds is considered as one of the alternative weed control options for areas or production systems where the use of chemical herbicides is not permitted or feasible," said Erin Rosskopf, USDA, Agricultural Research Service, Fort Pierce, FL. "Plant pa...JCI table of contents: September 1, 2006
...to harbor many infection-specific Tregs that might suppress their immune system. In an accompanying commentary, Lucienne Chatenoud and Jean-Franois Bach from Hpital Necker-Enfants Malades in France discuss how these data seem to provide the first evidence of a population of adaptive Tregs (that is, Tregs ge...DOE JGI, VBI describe disease mechanisms of sudden oak death, related soybean pathogens
...produce gene products that enable them to evade or suppress the plant's defense responses during infection and later produce gene products that kill and destroy plant tissue. "What is extraordinary about the Phytophthora genomes is that almost half of the genes contained in them show signs of rapid adaptati...Study shows how cancer drug aids anti-cancer virus
... immune response, making it unnecessary to totally suppress the immune system when using this treatment." In the late 1990s, a student of Chiocca's discovered that the virus killed tumors more effectively when the animals were first given the drug. Chiocca then set out to learn why. In this study, one of ...Dartmouth researchers find key player in immune system regulation
...ected to the activity of regulatory T cells, which suppress immune responses. The researchers say theirs is the first study to find that mast cells mediate immune system suppression. "Our finding is a complete surprise. We were studying transplant tolerance and what's required to protect a graft from rejec...Forsyth scientists develop system for automated analysis of behavior
... or stimulants, counteract effects of neurotoxins, suppress pain, modulate the activity of other psychoactive compounds, or serve as antidotes to drug addiction. How it Works The device basically consists of a set of small chambers monitored by digital cameras. Each chamber contains a complex set of light...Cooling analgesia harnessed to relieve chronic pain
...apies would make use of the body's own capacity to suppress pain. The discovery of a novel biological mechanism by which cooling analgesia works therefore has great potential for relieving the suffering of millions of chronic pain patients....Friendly bacteria in chewing gum that bites back
... antimicrobial properties, have also been shown to suppress the bacteria that fight tooth decay. Other potential uses of Lactobacillus include the prevention of body odour. BASF are looking into producing a deodorant based on L. aladoris, which can inhibit odour-producing bacteria in the armpit. Similarly, ...Researchers seek to solve mystery of natural HIV control
...few HIV-infected individuals are naturally able to suppress replication of the virus. The Elite Controller Co...t cure or prevent infection but could successfully suppress viral levels. Since this natural ability is so rare, we need to work with collaborators around the ...Scientists discover age-regulated cellular activities that protect against protein aggregation
...nce (RNAi), a naturally occurring process known to suppress certain gene activity in living cells, to lower the activity of the IGF signaling pathway. Indeed, this approach worked and the researchers discovered that if aging was delayed, the onset of proteotoxicity was also postponed. "In switching this pa...Loosen up, DNA: Leukemia gene changes genetic packaging
...that is unavailable, known as heterochromatin, can suppress tumor growth by keeping genes that tell cells to g...cer directly, or knock out genetic mechanisms that suppress cancer. "A molecule that is both an oncogene and that also antagonizes a tumor suppressor mechanis......ber of drugs currently in development or in use to suppress appetite or trigger weight-loss are also known modulators of anandamide signaling and given the results presented in the current study "such drugs need to be carefully evaluated to judge their effects on women of reproductive age and those that are p...