MicroRNA processing and cancer
... determined that that blocking Drosha activity can suppress miRNA production in cancer cells. "The alterations in miRNA expression that are observed in cancer are dramatic. Our studies raise the possibility that a single regulatory event could be the cause of this widespread miRNA mis-regulation. Understandin...JCI table of contents: July 27, 2006
... GC-induced osteoporosis. TITLE: Glucocorticoids suppress bone formation via the osteoclast AUTHOR CONTACT: Steven L. Teitelbaum Washington University School of Medicine, St. Louis, Missouri, USA. Phone: (314) 454-8463; Fax: (314) 454-5505; E-mail: teitelbs@wustl.edu . View the PDF of this article at: ...Invasive plants prefer disturbance in exotic regions over home regions
...cs. The researchers suggest that soil pathogens suppress the growth of certain species and may contribute to the disproportionately powerful effect of disturbance in introduced regions. "The potential for disturbance to have much stronger effects in invaded systems than in native systems is not trivial,"...JCI table of contents: July 20, 2006
...st that this demonstration that targeting TAMs can suppress tumor growth and metastasis could lead to the development of new therapies for cancer. TITLE: Targeting tumor-associated macrophages as a novel strategy against breast cancer AUTHOR CONTACT: Rong Xiang The Scripps Research Institute, La Jolla, Ca...Speeding discovery of the 'human cancer genome'
...r-causing genes or the loss of genes that normally suppress tumor formation. But as genome technology continues to improve, providing ever-increasing resolution, researchers have found more than they had expected, Chin said. In human melanoma, for example, more than 100 genomic regions exhibit recurring s...JCI table of contents: June 22, 2006
...elivered DNA-based vaccine, they can significantly suppress the growth and spread of multidrug-resistant colon and breast carcinomas in mice. By disrupting collagen type I expression the authors were able to significantly increase tumor uptake of chemotherapeutic drugs, resulting in tumor rejection and a 3-fo...Molecular 'brake' found for neurofibromatosis 1
...ces becomes unstable and can no longer effectively suppress the Ras oncogene. As a result, Ras becomes over-stimulated, and this in turn leads to the formation of the tumors along the nerve fivers." Scientists have not fully understood how and why the mutated neurofibromin gene leads to activation of the Ras ...Parkinson's disease mechanism discovered
...egulating trafficking could also be switched on to suppress alpha-synuclein toxicity in yeast cells. "Our find...ded to test whether enhancing Ypt1p activity would suppress alpha-synuclein toxicity in animal models of the disease. Fortunately, we had an excellent team of c...JCI Table of Contents, June 15 2006
...dermis of wounded skin exceeded those necessary to suppress or prevent the growth of foreign microbes. The results of this study demonstrate that wounding of the skin alone, without the presence of microbes, is sufficient to activate defense mechanisms in the skin that can prevent microbial growth and related...HIV-1's high virulence might be an accident of evolution
...s, including the less virulent human strain HIV-2, suppress the expression of a receptor normally found on the surface of T cells, making the immune cells less responsive to activation, the researchers found. In contrast, they report, the nef gene of HIV-1 and a subset of closely related SIVs failed to limit ...Scientists tie several cancers to common 'oncogene engine'
...arcoma. While no drug currently exists to directly suppress MITF, the identification of MITF's role opens a door to potential therapies because the researchers have identified some of the genes and proteins that MITF regulates that new drugs could be used to block. One of the targets is Bcl-2, which enables c...Leptin found to control appetite and limb development in frogs
...nd other mammals, leptin acts on the frog brain to suppress appetite. But the hormone also seems to play a role in the complex signaling that turns a finned tadpole into a four-legged frog, according to Robert Denver, an associate professor of biology at the University of Michigan. Denver's team gave frogs a ...Chronic neuropathic, 'phantom' pain comes from affected nerve and spinal cord, not brain
...ouraged, Smith said. Another possibility may be to suppress the immune system for the initial five days after injury. This may curtail the inflammation associated with peripheral nerves that appears to trigger many aspects of neuropathic pain. According to lead author Sridhar Balasubramanyan: "Clearly, what......treated with the drug cyclosporine often given to suppress the immune system before organ transplants tended to lose bone mass. Those patients were also at increased risk of bone fractures, said first author Winslow, who led the study as an HHMI predoctoral fellow in Crabtree's lab. Winslow is now working ...Gene therapy prevents the onset of diabetic symptoms in mice
...increase in regulatory T cells, which are known to suppress the activation of the immune system. However, the most important aspect of our study is that we've shown it is now possible to efficiently insert genes into beta cells in a living organism, allowing us to analyze the effects that different gene produ...Fox Chase study sheds light on cancer susceptibility and disease involving bone-marrow failure
...is governed by a gene, p27, that normally works to suppress tumors," Ruggero pointed out. "This could be a key explanation for the increased tumor susceptibility seen in patients with dyskeratosis congenita. "Two other proteins found in the study, XIAP and Bcl-xL, are involved in regulating the normal dying ...New findings help pinpoint autism's genetic roots
...used on a gene called Pten, which is also known to suppress cancers in humans. Some people with autism have mutations in Pten, but it has been unclear if that's what causes the disease, Dr. Parada said. To test that hypothesis, the researchers deleted the gene in the front of the mouse brain and in areas of t...Patent awarded for LSUHSC-developed peptide that blocks lethal toxins of anthrax
...research team set out to make a peptide that would suppress furin activity. In collaboration with a research group in California (Torrey Pines Institute for Molecular Studies), the LSUHSC group developed the furin inhibitor, D6R. The LSUHSC research group working on anthrax under the direction of Dr. Iris Lin...Novel stem cell technology develops a new cell for repairing spinal cord injuries
...n contrast, transplanted precursor cells failed to suppress scar formation or promote the growth of any nerve fibres across the injury site. Importantly, in a sensitive test of limb placement during walking, rats that received the astrocyte transplants recovered and were able to walk normally within two weeks......ion and inflammation. Because cannabinoids seem to suppress activated white blood cells, Tohyama believes they could have a potential use in the treatment of inflammatory diseases....