Boosting newborns' immune responses
... adenosine alters the physiology of white cells to suppress production of TNF-alpha (but not of IL-6) when TLR...erns may serve an evolutionary purpose. Nature may suppress babies' production of inflammatory cytokines like TNF-alpha and IL-12 before birth because they can ...A broken stress response system can contribute to Gleevec resistance
...tion of a gene called Arf, which normally helps suppress the growth of cancer cells. Mutations in the Arf gene are found in the cells of more than 30 percent of patients with ALL, whereas they have not been observed in patients with CML. The researchers found that when the Arf gene was inactivated, BC...Why nerve cells work faster than the theory allows
... help the cells transmit fast changing signals and suppress slow signals. (Nature, Volume 440, Number 7087, 2006) Every living cell maintains a voltage difference across its cell membrane. Nerve cells distinguish themselves from other cells in that they use this voltage difference to process and transmit mes...Just the expectation of a mirthful laughter experience boosts endorphins 27 percent, HGH 87 percent
...o can offset symptoms of chronic stress, which can suppress various components of the immune responses, particularly those related to anti-viral and anti-tumor defenses. In addition, there appears to be a rebalancing of the Th1/Th2 immune response which suggestively could lead to reduction of autoimmune issue...One big biology question solved
...the case of an infertile couple wanting a baby, or suppress it, in the case of pest management. Professor Koopman also suggested that an inappropriate retinoid signal might give the wrong instructions to germ cells, which could lead to the formation of germ cell tumours. "Our research has suggested a possib...JCI table of contents, March 16, 2006
...ponent of the cell wall of yeast, actually acts to suppress the immune response. The researchers stimulated hu...impaired ability of TGF-beta to activate Notch and suppress the immune response. These studies demonstrate that coordination of membrane-bound TGF-beta expressi...New evidence suggests statins could prove useful in treating MS
...06) that suggests a mechanism by which Lipitor may suppress the production of pro-inflammatory cytokines associated with central nervous system autoimmune disease. Study findings indicated that the drug's effects on the immune system occur independently of its cholesterol-reducing effects. And it builds on th...New target for obesity and related metabolic disorders
...n a high-fat diet, acted on the target receptor to suppress appetite and weight gain in the animals, they found. As reported by Hilary Overton, Christine Reynet, and colleagues of the biotechnology company (OSI)Prosidion, the team found that so-called oleoylethanolamide, a naturally occurring lipid-signaling...Infection 'alarm' yields clues to immune system behavior
...ng target for new medications designed to boost or suppress the immune system, the researchers said. An overactive immune system, for example, can set off the excessive inflammation associated with rheumatoid arthritis and lupus. In addition, some cancers are more likely to grow where inflammation occurs. The...Living taste cells produced outside the body
...w taste stimuli interact to enhance good tastes or suppress unpleasant tastes. Similarly, new molecules, including potential artificial sweeteners or bitter blockers, can be evaluated to see if they interact with taste receptors to activate the cell. Another important avenue for research aims to help people ...New study shows antibody-interleukin complexes stimulate immune responses
...also stimulates CD4+ T regulatory cells, which can suppress those same memory T cells. Therefore, the prevailing view was that administration of IL-2 mAb removes the IL-2-dependent CD4+ T regulatory cells, which in turn leads to an expansion of CD8+ T cells. "In the study, however, we noticed that the enhanci...High-status monkeys ignore the interests of riff-raff
...d levels of the male sex hormone testosterone, may suppress so-called "social vigilance," which is high in low-status males that readily follow the gaze of others.......than previously realized. If brevetoxins similarly suppress human and manatee immune systems, as Bossart believes is likely, then it could open those exposed to brevetoxins to ailments not currently associated with the red tides. This would pose a serious problem to residents of southwest Florida, where red t...Study finds drug may cut down involuntary movements
...ugs like haloperidol (Haldol) are commonly used to suppress chorea, but they cause many different side effects. This study shows that tetrabenazine can decrease chorea, and the drug is well-tolerated by most research subjects," said Shannon. Tetrabenazine was originally developed in the 1950s to treat psycho...Studies of obese children reveal body-weight control hormone
...d from the same precursor protein that is known to suppress appetite in humans and rodents. "The assumption had been that α-MSH was most important at keeping energy balanced in people," O'Rahilly said. "The new studies point the finger at the neglected sibling, -MSH." Both α-MSH and -MSH are derived...Barrow Neurological Institute neuroimmunology fellow receives $135,000 fellowship award
...lls to produce a protein that allowed the cells to suppress MG when induced experimentally in mice. These research findings were published in December 2005 in The Journal of Immunology. With the Muscular Dystrophy Association fellowship award, Dr. Liu will work over the next three years to identify key elemen...Partner proteins may help estrogen foster breast cancer
... in partnership with other proteins to activate or suppress gene activity in breast cancer cells. Surprisingl...ed seven partner proteins that help ER activate or suppress gene activity in breast-cancer cells. And one of the activating partner proteins was c-MYC. But wer...JCI table of contents, February 1, 2006
...he mechanisms by which high glucose concentrations suppress PI3K activity." TITLE : GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathwayAUTHOR CONTACT: Shanthi Srinivasan Emory University, Atlanta, Georgia, USA Phone: (404) 727-5298; Fax: (404) 712-2980; ...Other highlights in the February 1 JNCI
...negatively regulates cell growth and survival, can suppress tumor growth in squamous cell carcinoma of the head and neck (SCCHN) tumors. When the promoter region of the STAT1 gene is chemically modified by a process called promoter hypermethylation, thereby inhibiting STAT1 expression, the result can increase......RNAs, tiny, recently discovered RNA molecules that suppress gene expression. Increasing evidence indicates a role for microRNAs in the developing nervous system, and researchers from Children's Hospital Boston now demonstrate that one microRNA affects the development of synapses the points of communication b...