Novel protein in St. John's Wort found to suppress HIV-1 gene expression
...olecular mechanism by which the protein is able to suppress HIV-1 gene expression and replication, according to Khalili. It is the expression of the viral gene and the replication of the viral genome that leads to the development of AIDS in HIV-infected individuals. "Our studies indicate that p27SJ has the ...Stem cells' electric abilities might help their safe clinical use
... "Our findings may lead to genetic strategies that suppress undesirable cell division after transplantation, not only for ESCs and their derivatives, but perhaps for adult stem cells as well." Li adds that much more work is necessary to know for sure....Molecular drug pump may help reduce risk of Alzheimer's
...iliar with a variety of drugs that can promote and suppress Pgp activity. The new connection may, for example,...ed over extended periods of time are also known to suppress Pgp activity. These drugs include some calcium channel blockers, immune suppression drugs and anti-d...Multiple sclerosis progression linked to immune-cell substance
...levels of immune-system cytokines or products that suppress inflammation . "Our evidence overall suggests that the inhibition of this steroid hormone by MIF has an important influence on the immune system and in determining whether the disease progresses or not," Whitacre says....A fatty acid found in milk may help control inflammatory diseases
...ing antibiotic resistance," he adds. "You can also suppress the animal's immune system, but that makes it much more susceptible to disease." However, Cook is interested in another approach: Using CLA as a natural way to prevent "collateral damage" from the immune system's response to invading pathogens. "The ...First evidence of brain abnormalities found in pathological liars
... the mindset of the other person. You also have to suppress your emotions or regulate them because you don't w...us. There's quite a lot to do there. You've got to suppress the truth. "Our argument is that the more networking there is in the prefrontal cortex, the more th...JCI table of contents October 1, 2005
...ogenic genes. TITLE: Polyunsaturated fatty acids suppress glycolytic and lipogenic gene expression through the inhibition of ChREBP nuclear protein translocation AUTHOR CONTACT: Catherine Postic Institut Cochin, INSERM, Paris, France Phone: 33-1-53-73-27-07; Fax: 33-1-53-73-27-03; E-mail: postic@cochin...Microtubules critical to development of mental disorders
...n of the serotonin receptor known as 5-HT1AR is to suppress the activity of the NMDA receptor by coupling to cellular signaling, which depolymerizes microtubules," said Yuen, first author on the paper. "The breakup of microtubules, in turn, interrupts NMDAR delivery to the neuronal surface, resulting in suppr...... that a commercially available antibody is able to suppress the inflammation that occurs in connection with spinal cord injury and in doing so supports nerve regeneration. The first studies on humans are already planned. Hans R. Schler was full of eagerness when he closed the meeting: "The best meetings are t...Fungus helps tall fescue choke out native plants
...be that infected tall fescue grass will spread and suppress native plants," said co-author Jennifer Rudgers, n...d fenced plots were sprayed with an insecticide to suppress insect herbivores. Tall fescue progressed most slowly in plots that were both sprayed and fenced, co...A step closer to a malaria vaccine
... been entirely effective, only able to temporarily suppress the disease. A complete, fully protective malaria vaccine will likely consist of several components, each only partially successful at fighting malaria on its own. The potential "part" studied here is a protein known as "Apical Membrane Antigen 1" (A...Improving the potential of cancer vaccines
... off the function of a special group of T cells to suppress immune response to tumors and even infectious dise... (Treg for short). These cells have the ability to suppress the body's natural immune response. If they are depleted, autoimmune diseases will result because th...Leptin-signaling protein maintains normal body weight and energy balance in mice
...d out chemical signals called neuropeptides, which suppress appetite and make us stop eating. When the system works properly, the body maintains a natural balance between energy taken in as food and energy expended in activity. "It's like the feedback mechanism on a thermostat set to maintain room temperature...Grasshopper love songs give insight into sensory tuning
...gth of those connections adaptively, to amplify or suppress connections. Some four decades ago, a general principle called the "efficient coding hypothesis" was formulated, holding that sensory systems adjust to efficiently represent the complex, dynamic sounds, sights, and other sensory input from the enviro...Building a better mouse model of lung cancer: FHIT counts
... very low levels of the protein might be enough to suppress or even prevent lung cancer," says Huebner. Huebner had a hunch that pairing loss of protein with the loss of another tumor suppressor might enhance the research value of the new mouse model even more, so the research team bred another strain of mic...Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine
... the first evidence of plague vaccines that do not suppress innate immune responses and that may be useful for plague vaccination in animals, and, perhaps, humans." The next steps include testing in other animal models, said Schneewind. The two papers combined, Schneewind suggested, are a good example of ho...Parasites trigger healthy eating in caterpillars
...re . Many parasites have developed mechanisms that suppress their hosts' ability to fight them off or even change their behavior in favor of the parasite. "We found the opposite is true with tiger moth caterpillars and their parasites," said UA Regents' Professor Emerita Elizabeth Bernays. Bernays discovered...W. M. Keck Foundation announces 2005 class of Distinguished Young Scholars in Medical Research
...ptive mechanisms interact with genes that cause or suppress tumors. The research could lead to treatments to boost the effectiveness of other cancer therapies or prevent recurrences. Kang Shen, M.D., Ph.D., Department of Biological Sciences, Stanford University, Stanford, CA Dr. Shen studies how the nervo...Identification of a protein important for Hepatitis B replication
...include lamivudine and alpha-interferon which also suppress viral replication by attacking the virus itself, but the identification of the action of this protein offers new therapeutic opportunities by targeting the human proteins that help the virus to replicate.......trated that by lowering Stat3 hyperactivity we can suppress stomach cancer formation, importantly without affecting Stat3's other important roles in the body. Add to that the evidence suggesting that Stat3 is also involved in breast, head and neck, and prostate cancers, and we have a compelling case for inves...