JCI table of contents -- July 26, 2007
...Ca-ATP] channels. The authors went on to show that suppression or blockade of SUR1 activity following spinal cord...al role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cellassociated antigens AUTHOR CONTACT: Masato Takana RIKEN R...Immune system 'escape hatch' gives cancer cells traction
...out injections of MDSCs. They found an 80 percent suppression of the immune response in the presence of MDSCs, confirming that the suppressor cells were inactivating the T cells. The Florida team then turned to Schneck, who in 1993 developed several novel proteins to test how various antigens, such as those o......months of induction therapy should achieve durable suppression of HIV and maximize the possibility of eradicating viruses resistant to the maintenance regime. They also find the counter-intuitive result that for induction regimens of limited duration the optimal time to initiate induction therapy may be several ...University of Cincinnati receives $1.7M to research molecular treatment of brain injury
...and stroke. Strauss then shifted his focus from suppression of the harmful COX-2 enzyme to the potential for elevating two theoretically helpful eicosanoids, known as HETEs and EETs. We believe eicosanoids reduce the number of inflammatory cells that fester around the injury site and cause chronic tissue d...New research holds promise for protecting cancer patients against infertility
...GnHR analogues were already used for the temporary suppression of ovulation in infertility treatment, so reasoned that it would be possible to use it to shut down the ovaries temporarily during the time that chemotherapy was administered, and hence protect them from the effect of the drugs. The women were give...Researchers discover method for identifying how cancer evades the immune system
... that of mice. In all cases, the researchers saw a suppression of CD83 and CD28, two genes that affect activation of immune cells, and over-production of B7-H4, a gene whose protein product inhibits immune activation. The human colorectal cancers, however, showed variations in their immune signatures, which rese...Key to tackling malaria may lie in bed nets for adults and older children
...insecticide-treated nets, including community-wide suppression of malaria transmission, can be realised across Africa, we could prevent hundreds of thousands of deaths each year." The research was welcomed by Dr Alex Mwita, programme manager for the National Malaria Control Programme in Tanzania. "Malaria i...Stressed-out African naked mole-rats may provide clues about human infertility
...nd of a continuum of socially-induced reproductive suppression among mammals, with other examples including prima...queen and the non-breeders are translated into the suppression of certain fertility hormones (luteinizing and follicle stimulating hormones). In the non-breeding f...Potato wart eyed as risk to potato production
...lack of suitable chemical controls for potato wart suppression make this disease especially problematic for any t...ping and improving reliable and integrated disease suppression methods to directly deal with this disease," said Franc....Other highlights in JNCI, June 12
...eloping glioma and increased tumor growth, whereas suppression of the gene was associated with the inhibition of tumor growth. Our results support the rationale for developing CCRK as a potential therapeutic and diagnostic target for glioblastoma multiforme, and, possibly, other cancers, the authors write. ...Study shows big power of small RNAs, not just proteins, in halting cancer
...lead to a deeper understanding of a critical tumor suppression mechanism but also may provide insight into how to best engage the p53 pathway to treat cancer by killing tumor cells, said He. ...JCI table of contents -- June 1, 2007
...dstream by fatty tissue and it plays a role in the suppression of inflammation-associated metabolic disorders that may result in type 2 diabetes, obesity, and atherosclerosis. In the June 1 issue of the Journal of Clinical Investigation, Rosario Scalia and colleagues from Thomas Jefferson University studied the ...LIAI scientists make important finding on cytomegalovirus transmission
...p will be conducting animal studies with the IL-10 suppression and the OX40 enhancement combined into one treatment. "We tested them separately, but they may well be even more effective when combined," Croft said....JCI table of contents -- April 19, 2007
...ophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy AUTHOR CONTACT: Gnther Schtz German Cancer Research Institute, Heidelberg, Germany. Phone: +49-6221-423411; Fax: +49-6221-423470; E-mail: g.schuetz@dkfz.de . Jan P. Tuckermann Fritz Lipmann Institute, ...Slow but sure -- Burned forest lands regenerate naturally
...ere was no evidence of recent conifer mortality or suppression leading to seedling death. Total conifer density... wildland, fire and research organizations. Fire suppression and fuel buildups, among other possible causes, have led to an increasing frequency and severity of ...Natural mechanism for immune suppression paves way for cancer trials
... of other drugs to be used. Another goal for IDO suppression is to treat chronic infections that induce this mechanism, Dr. Mellor says. "This mechanism is induced by pathogens to protect themselves from host immunity," says Dr. Mellor. "HIV certainly is a potent inducer of this mechanism." He suspects othe...Gene mutations linked to hereditary lung disease
...rk," she explains. "If were not so tied to immune suppression therapies, we could eventually tailor drugs to a different target."...News tips from the Journal of Neuroscience
...roglia as part of inflammatory responses. Although suppression of OPN results in a better outcome in animal models of autoimmune disease, Hashimoto et al. report this week that OPN may be neuroprotective in spinal cord injury. The authors compared the effects of a spinal cord contusion at T13 in wild-type (WT) a...Other highlights in the Feb. 21 JNCI
...d that KISS1 secretion was required for metastasis suppression of the melanoma cells. Only the cells with the intact form of KISS1 secreted kisspeptins, and these cells showed less metastatic activity when they were injected into the mice than those with the altered version. Mice that were injected with the gene...Central and peripheral signals set the circadian liver clock
...ERBa that shuts down circadian gene expression via suppression of a clock gene Bmal1. The modified gene had tetracycline-responsive elements (TREs), that respond to tetracycline and similar antibiotics. Mice with this modification were bred with a strain carrying a gene construct that activates the elements spec...