Study describes basic mechanism in cell growth control involving damaged DNA
... of proteins no longer needed, including the tumor suppressor protein p53," said Xiong. This protein stops the cell from growing or kills it, he added. "If the cell is growing happily, it would not want p53 around. So it places ubiquitin on it, slating it for degradation, for recycling when it's needed." In the...Muscling in on a deadly cancer
...e of Forkhead of Fkhr, a gene that acts as a tumor suppressor to control cell division, which runs amok in cance... Pax3:Fkhr cancer gene and deactivate either tumor suppressor gene, Keller says. Mice previously have been created to develop the less deadly...New version of tumor-suppressor linked to progression of childhood cancer
...iously thought to function exclusively as a cancer suppressor in neuroblastoma (NB), a highly aggressive and deadly childhood cancer. The study, published in the October issue of Cancer Cell, reveals new evidence about what stimulates progression of neuroblastoma and may provide a likely target for new anti-can...Manipulation of epigenome turns off as many genes as it turns on
...hat normally stifle cell growth -- so-called tumor suppressor genes -- are shut down because extra methyl groups are hanging on to them. If these extra methyl groups could be removed, the thinking has gone, the gene could be restarted and the cancer slowed or stopped. But the new work shows that while the ag...Urine testing might prove to be an alternative screening test for cervical cancer
...act is titled, "Promoter hypermethylation of tumor suppressor genes in urine from cervical cancer patients." The study included urine testing of women from Senegal, West Africa. Urine samples were taken from 41 women with negative or low-grade lesions, 72 women with invasive cancer, and 30 women with high-g...Newly discovered protein suggests novel tumorigenic pathway
...ating PTEN, the second most commonly mutated tumor suppressor in human tumors. This discovery suggests the poss...cular Biology journal. Mutations in the PTEN tumor suppressor are found in a variety of human cancers including breast and prostate cancers. Approximately 20 per...JCI table of contents November 1, 2004
...otects Intestines from Inflammation TITLE: Kinase suppressor of Ras-1 protects intestinal epithelium from cytokine-mediated apoptosis during inflammation AUTHOR CONTACT: D. Brent Polk Vanderbilt University, Medical Center North, 21st and Garland Avenues, Nashville, TN 37232, USA Phone: 615-322-7449; Fax: 615-3...Researchers uncover how infections combat plant immune responses
...this approach, e.g., by directly targeting the CTV suppressor genes," Ding said. "Our work indicates for the fi...ime that viruses may have to produce more than one suppressor of RNA silencing to overcome the antiviral immunity," he added. "Secondly, one of the CTV suppressor...U-M researcher examines the cell's housekeeping habits
...o promote and prevent cancer. Its works as a tumor suppressor when it limits cell size and removes damaged machinery in the cell that could generate free radicals or create genetic mutations. But, paradoxically, autophagy may protect cancer cells against some cancer treatments and it might also make cancer cell...Cell enzyme may help suppress cancer development
...e strongly suggests that the PTPRO gene is a tumor suppressor gene. If further research verifies the importance of the PTPRO gene to the cancer process, it may mean that measuring the degree of methylation of this gene in a patient's tumor will tell doctors something about the level of danger posed by that tumo...NYU team develops enhanced algorithm for detecting changes in cancer genomes
...y, points to locations of both oncogenes and tumor suppressor genes. In addition, the algorithm can be used to account for the varied genomes present across human population. An earlier version of the algorithm as well as several other competing algorithms were capable of dealing with only cancer data or only ...New protein identified in development of lung cancer
...dentified protein that can flag an important tumor suppressor gene for destruction may be a key player in the de... activity of p53 possibly the most powerful tumor suppressor in the entire genome. When it functions normally, p53 regulates several critical cellular processes,...Other highlights in the November 17 JNCI
... May Reduce p53 Activity in Lung Tumors The tumor suppressor protein p53 is a key regular of the cell cycle, and the p53 gene is the most frequent genetic defect in human tumors. The protein Pirh2 was recently discovered to negatively regulate p53 by targeting the protein for degradation. In a new study of hum...UT Southwestern researchers locate gene family involved in determining potential for acquiring lupus
...completely impaired. If we can understand what the suppressor gene is doing to block SLAM/CD2, we may be able to tweak the immune system back into normal balance." Other Center for Immunology contributors to the Immunity study were Dr. Amy Wandstrat, assistant instructor; Xiang-Hong Tian, senior resear...MIT creates new model of cancer syndrome
...ch shows that a single point mutation in the tumor suppressor gene p53 yields a mouse that develops a broad tumor spectrum that is reminiscent of LFS. Although LFS is a rare genetic disease, affecting fewer than 400 families worldwide, the p53 gene is also very commonly mutated in tumors unrelated to LFS. Mut......edd4 as an agent of endocytosis. Nedd4's role as a suppressor of Notch was illustrated even more plainly when the lab showed that inhibition of Nedd4 results in the upregulation of ligand-independent activation of the Notch pathway. Nedd4's place in the greater scheme of Notch signaling became clearer when the ...Researchers tease out one critical role of tumor-suppressor gene
...s cell division in check. That means Rb is a tumor suppressor gene, which keeps cells from growing out of contro...ue scientists in to the gene's behavior as a tumor suppressor and why it mutates. It could also ultimately help scientists understand how other types of cancer pr...Stowers researcher answers fundamental question of cell death
...t mice and found that Bruce regulates p53, a tumor suppressor gene, and the mitochondrial pathway of apoptosis. Bruce's primary function resides upstream of mitochondria. Loss of function of Bruce increases the level of p53, making cells more sensitive to apoptosis. The transcriptional activity of p53 is respo...New cancer gene identified by Memorial Sloan-Kettering scientists
... the function of other proteins, including a tumor suppressor called ARF. The mice developed aggressive, fatal forms of lymphoma. In further work, using a technique called tissue micro arrays to study tumor samples from people with many types of cancer, they confirmed that Pokemon is present in very high levels...Protein tyrosine phosphatases to be topic of ASBMB-Merck Award lecture
...ns have shown that PTPs can also function as tumor suppressor genes. The PTEN gene, which is among the most commonly mutated tumor suppressor genes in human cancer, is a member of the PTP superfamily. Like many other tumor suppressors, PTEN t...