New tumor suppressor gene linked to cancer predisposition
... of control. ARLTS1, on the other hand, is a tumor suppressor gene a gene that normally helps the body identify and destroy suspicious-looking cells before they undergo malignant transformation and spread. When ARLTS1 is altered, it loses that ability, giving tumors a chance to establish themselves and grow. T...Blocking COX-1 slows tumor growth in mice
...arian surface epithelial cells that lacked a tumor suppressor gene. In the current study, the Vanderbilt researchers used Orsulic's model to test whether celecoxib (Celebrex), a selective COX-2 inhibitor, and SC-560, an experimental drug that selectively blocks COX-1, slowed tumor growth when these cells were ...Mosaic mouse technique offers a powerful new tool to study diseases and genetics
...l gene is lost. For example, if you delete a tumor suppressor gene, the green cells will proliferate, and you can actually study the tumor's progression. If you can image these cells in a live animal, you can potentially watch the tumor grow." Luo points out that MADM is more precise than the widely used "knoc...Chromosome deletion predicts aggressive neuroblastoma
...pparently removes the protective effect of a tumor suppressor gene, and thereby allows the tumor to grow. Patients in the study with the chromosome deletion had a three-year overall survival rate of 66 percent, compared to 83 percent for patients without the deletion. Dr. Attiyeh's research abstract received to...Ancient immune defense mechanism is no match for HIV-1
... transcriptional activator, also can function as a suppressor of RNA silencing (SRS). Tat helps HIV-1 to elude the cell's natural RNAi defense by interfering with the ability of Dicer to process dsRNAs. "Our results suggest that the dynamic interplay between RNAi and SRS remains physiologically conserved fr...MSKCC researchers uncover structure of key protein complex in cells
...n to allow its accumulation, thus enabling the p53 suppressor protein to stifle the formation of tumors. Three scientists -- two Israelis and an American -- were awarded the 2004 Nobel Prize in Chemistry for their work showing that ubiquitin marks other proteins for destruction. SUMO-1 does not appear to label...New regulators of apoptosis and chemoresistance identified
...pressors. "Down regulation of many of these tumor suppressor phosphatases resulted in a marked cellular resistance to conventional chemotherapeutic agents. Therefore, finding out whether some of these phosphatases have inactivating mutations in specific cancers may help overcome drug resistance," said MacKeiga...Discovery offers promising lead in prostate cancer diagnosis
... cancer-causing genes known as oncogenes and tumor suppressor genes have long been known to be major factors in ...he U.S., the identification of oncogenes and tumor suppressor genes that are altered in most prostate cancer cells have eluded scientists thus far. Dr. Charles Bi...Engineered skin offers clues to melanoma development
...terfere with the retinoblastoma (Rb) and p53 tumor suppressor pathways, which normally act to keep cell growth in check, as well as human telomerase reverse transcriptase (hTERT), the enzyme that protects the ends of chromosomes during cell division. This enzyme is associated with the progression of many cancer...Other highlights in the June 15 JNCI
...hair follicles and pulmonary cysts, may be a tumor suppressor gene that predisposes a person to renal tumors whe...lleagues hypothesized that BHD may also be a tumor suppressor gene. They examined the BHD gene in 77 renal tumors from 12 patients with germline BHD mutations. Th...Most common lung cancers may begin in newly discovered cells
...rly, and if the mutation happens to affect a tumor suppressor gene or oncogene, it could start the process of forming a tumor. There are certainly suggestions that various tumors might arise in locations where there has been a previous injury." The researchers acknowledge that the ultimate stem cell test remain...Cancer related gene p53 not regulated as indicated by previous tissue culture research
...maged DNA to self-destruct pivots on the p53 tumor suppressor gene. If p53 is inactivated, as it is in over half...sures. When higher than normal levels of p53 tumor suppressor exist, there is enough p53 to bind to many regulatory sites in the cell's genome to activate the pro...JCI table of contents August 1, 2005
...lar to these latter, are anergic ex-vivo and exert suppressor functions. NnTregs represent a pure population of nave naturally-occurring regulatory T cells, whereas Tregs are most likely composed of a mixture of NnTreg-derived antigen-experienced regulatory T cells, recently activated CD4+ T cells, and, possib...... genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2. Together, the studies shed new light on the long-standing question as to how the loss of either protein (which act in the same pathway to inhibit mTOR signaling and cell growth) can have such dramatically different effects o...Biased reporting found in cancer prognostic studies
...ished studies alone have focused on a single tumor suppressor protein (TP53) that may predict the outcome of a patient with head and neck cancer. As researchers attempt to make sense of the growing mountains of information, some are beginning to question the validity and possible biases in many of the studies....Building a better mouse model of lung cancer: FHIT counts
... FHIT for years, noting it is one of several tumor suppressor genes residing on chromosome 3 in humans that, whe...ing loss of protein with the loss of another tumor suppressor might enhance the research value of the new mouse model even more, so the research team bred another...BRCA1 tumor suppression nullified by cyclin D1 at the estrogen receptor
...e mechanism by which cyclin D1 nullifies the tumor suppressor activity of BRCA1. "Cyclin D1 is a collaborative ...n this paper describes an important oncogene/tumor suppressor interaction." The tumor-promoting action of various oncogenic sources upregulating expression of cyc...Customized gene chip provides rapid detection of genetic changes in children's cancer
...a pair of genes. When the gene involved is a tumor suppressor gene, LOH removes a brake on uncontrolled cell growth, the growth that is the hallmark of cancer. Researchers in Dr. Maris' laboratory previously established that LOH in a region of chromosome 11 allows aggressive neuroblastoma to take hold. The ne...Other highlights in the August 3 JNCI
...rkers. In cancer cells, the transcription of tumor suppressor genes is often silenced by increased or aberrant DNA methylation, and aberrantly methylated DNA has been proposed as a potential tumor biomarker. To determine whether methylation of the vimentin gene could be a possible biomarker for colon cancer, Sa...Researchers find BRCA1 tumor suppression nullified by cyclin D1
...hich cyclin D1 nullifies one activity of the tumor suppressor BRCA1. "Cyclin D1 is a collaborative oncogene and ...n this paper describes an important oncogene/tumor suppressor interaction." The tumor-promoting action of various oncogenic sources upregulating expression of cyc...