Tag: "suppressors" at biology news
Researchers uncover how infections combat plant immune responses
...steza virus (CTV) produces three proteins that are suppressors
of RNA silencing and each inhibits RNA silencing i...the need to remove CTV-infected trees. Since viral suppressors
are also known to interfere with plant development, further analyses of the CTV suppressors
Stowers researcher publishes DNA double-strand break repair discovery in Science
...complex that contained a number of candidate tumor suppressors
including a specialized histone variant called H2A.X/v. H2A.X/v itself becomes phosphorylated by a DNA damage- recognizing factor in the proximity of DNA double-strand breaks. This finding raised the possibility that the complex, which was called the...
Scientists reveal cells' 'energy factories' linked to cancer
...ochondria's energy generating machinery are tumour suppressors
and that defects in these genes can lead to cancer. But, until now, it was unclear as to how mutations in these genes resulted in the disease. The team looked at one of the known tumour suppressor genes called SDH, which codes for a molecule called ...
Study shows naturally occurring proteins protect against rapid tumor growth
...ngiogenic inhibitor molecules were acting as tumor suppressors
to control the rate of cancer progression. "For several decades now, autopsies have shown that many people [between ages 40 and 50] who have died of trauma [i.e. automobile accidents, suicide] have tiny dormant tumors in one or more of their organs,...
UC Riverside researchers discover model organism for studying viruses that affect humans
... screening chemical compounds that inactivate RNAi suppressors
associated with avian flu, HIV and others....
Protein aggregates in Lou Gehrig's disease linked to neuron death
...important to scientists looking to develop genetic suppressors
and therapeutics." Morimoto's team focused on SOD1 because it is a form of familial (hereditary) ALS in which a mutation in just one gene and its associated protein has devastating consequences to the cell. (Approximately 10 percent of ALS cases are...
Protein marker associated with positive outcome in invasive breast cancer
...o. "Targeting the BCA2 mediated breakdown of tumor suppressors
could provide a new therapy to block breast tumor growth." The Canada Foundation for Innovation and the Ontario Innovation Trust, now the Ontario Research Fund - Research Infrastructure, funded the infrastructure for this research. The Canadian Insti...
Common molecular 'signature' identified in solid tumors
...s the miRNA signature targets, including the tumor suppressors
retinoblastoma-1 (RB1) and transforming growth factor, beta receptor 2 (TGFBR2). Croce predicts that miRNAs themselves may one day be used as treatments. "If we can replace miRNAs that are lost and block those that are overly abundant, then maybe we...
Activation of microRNA inhibits cancer gene in human cancer cells
... impact regulatory RNAs that may function as tumor suppressors
in normal cells and proposes a novel strategy for treating human cancers. DNA methylation and histone deacetylation are epigenetic processes involved in the regulation of gene expression. In the case of cancer, these processes are thought to turn off...
Evolving defenses rapidly suppress male killers
...ow scant evidence has linked the evolution of host suppressors
to selfish elements that mediate male killing. How...hus, genetic conflict between killing abettors and suppressors
may be far more widespread than once thought, but has simply eluded detection. Given the diversity o...
Distinguishing friend from foe in the battle against cancer
...b previously showed that mouse cells lacking tumor suppressors
known as TSC genes are more susceptible to the lethal effects of chemotherapeutic agents than are normal cells. Why cells from these TSC null mice were so poorly equipped to survive was not entirely clear. Co-lead authors Sourav Ghosh, Ph.D., and Vi...
An AIDS-related virus tricks cells to become tumors, new Penn study finds
...or LANA, tricks the cell into destroying two major suppressors
of tumor growth called von Hippel Lindau (VHL) and...n that when LANA expression was blocked, the tumor suppressors
again become stable suggesting a direct role of the viral protein in regulation of these major cell ...
Genomic 'firestorms' underlie aggressive breast cancer progression
...and the locations of candidate oncogenes and tumor suppressors
in the genome. It will assist the researchers in identifying genes that drive cancer progression, and help unravel the complex yet elusive genetic pathway that underlies tumor metastasis....
Regulating the nuclear architecture of the cell
...le in the suppression of gene expression, known as suppressors
of variegation, were named Su(vars). The gene family known as Su(var)3-9 codes for proteins that chemically modify certain histones in the nucleosomes. Su(var)3-9 proteins attach methyl groups to the histone labeled H3 at its ninth amino acid resi...
Pair of microRNA molecules controls major oncogene in most common leukemia
...tranded RNA molecules that can act either as tumor suppressors
or oncogenes. They can block transcription of genes by stopping them from producing messenger RNA or can inhibit translation of the genes by blocking production of proteins from messenger RNA, according to Pekarsky. Earlier this year the investigato...
Simple diagnostic test detects genetic signs of lung cancer in a patient's sputum
...ed to check whether two genes believed to be tumor suppressors
are deleted in cells found in sputum, identified 76 percent of stage I lung cancer patients whose tumors also showed the same genetic loss. Existing sputum "cytology" tests, which look for changes in cell structure, identified only 47 percent of the ...
Reactivated gene shrinks tumors
... see if the same approach will also work for tumor suppressors
other than p53....
Gene knockouts reveal FoxOs' vital functions in cancer defense, health of stem cells
... transcription factors, normally function as tumor suppressors
that override maverick cells threatening to grow t...ncer, why did the knockout mice lacking FoxO tumor suppressors
not develop more types of cancers? It turns out that the cancer-causing pathway operates differently...
Researchers at IRB Barcelona discover a new mechanism that regulates stem cell division
... protein", explains Gonzlez, "is one of the tumour suppressors
that we described in 2005, which suggests that the centrosome plays a key role in preventing these stem cells from becoming malignant; a question to which we are currently devoting considerable research effort". These studies form part of a research ...
MicroRNAs as tumor suppressors
... (UVA) reveal that microRNAs can function as tumor suppressors
in vitro. "Overexpression of HMGA2 is an important feature of many medically important tumors like uterine fibroids, explains Dr. Dutta. It is very exciting to realize that microRNAs have an important role in suppressing the overexpression of HMGA...