JCI table of contents: Aug. 9, 2007
...rdiac remodeling occurs in mice engineered to have sustained inflammation in the heart (MHCsTNF mice) and is ac...ted only one pathway of apoptosis activated by the sustained inflammatory response the intrinsic apoptotic pathway of cell death. The extrinsic apoptotic pathwa...Sugar and spice and everything nice: Health differences in newborn girls and boys
...te in newborn female livers, a difference that was sustained throughout the ischemic period. Based on these findings and other considerations, the researchers concluded that: the newborn female liver developed a greater and more rapid tissue acidosis compared to males during normothermic ischemia, whic...ESA announces 2007 award recipients
...ition of an outstanding body of ecological work or sustained ecological contributions of extraordinary merit. Lange is one of the founding fathers of plant physiological ecology, and his impact on the field has been vitally important. He has 368 publications on the topic (92 since his retirement), has co-edit......ecosystems. Zeidberg and Robison's paper shows how sustained scientific monitoring efforts in the marine environment can help document such important biological shifts that might otherwise be missed....Faster-acting antidepressants closer to becoming a reality
...nd that targeting them directly led to such rapid, sustained relief of depression-like behaviors in this study and that a single dose of ketamine did the same in humans in the earlier study suggests that they are probably the key targets for antidepressant medications. In any other illness of depressions m...American Chemical Society's Weekly PressPac -- July 18, 2007
...t, used to represent an artificial cell, underwent sustained movement through a chemical solution for several minutes until finally coming to a stop. In doing so, the researchers say, the droplet demonstrated a primitive form of chemotaxis, one of the most basic cellular responses in which the cell directs its...UB scientist discovers novel iron-copper alliance
...a myriad of serious conditions, and life cannot be sustained without it. In novel research, investigators at the University at Buffalos School of Public Health and Health Professions, have learned that iron is only one half of an all-important duo of trace minerals -- the other being copper -- that work in tan...A novel molecular dictator 'with a conscience' discovered
...er intervention to re-open an occluded artery, for sustained symptom-free benefit you would be hoping for suppressed smooth muscle cell growth, without affecting endothelial cell growth, says Professor Khachigian. And thats exactly what happens when we simply top up blood vessels with the bodys natural rese...High blood pressure medication strategy proves effective in Hispanic women
...ly assigned to a drug strategy containing either a sustained release form of the calcium antagonist verapamil or the beta-blocker atenolol. The INVEST study enrolled more Hispanic patients than any other hypertension trial to date, Cooper-DeHoff said, and included Hispanic participants from the mainland Uni...5 OHSU faculty members singled out for honors
...gnize OHSU faculty members who have demonstrated a sustained and significant record of meritorious academic accomplishments. The winners each of whom has received $3,500 from the OHSU Foundation are: Research: Michael V.Danilchik, Ph.D., professor in the department of integrative biosciences in the School...VIB scientist receives major research grant
...and Marinee Chuah are the first to have achieved a sustained gene therapy cure for hemophilia A in mice. In the mice with hemophilia A, the researchers succeeded in raising the concentration of coagulation factor VIII 1000 times. Unfortunately, however, scientists ran into difficulties when testing the ther...Gene variations directly link inflammation to an increased risk for lung cancer
... of Cancer Epidemiology and Genetics. Essentially, sustained inflammation alters the microenvironment of the lung tissue, damaging cells and altering DNA. Inflammation is part of the immune systems arsenal to combat the effects of infection and cell damage. However, prolonged or intense inflammation could l...Chronically sleep deprived? You can't make up for lost sleep
... term, allostatic responses are adaptive, but when sustained on a chronic basis, such as in their study, an allostatic load will develop and lead to negative health outcomes. The allostatic load resulting from the accumulating sleep debt loops back to the sleep regulatory system itself and alters it. Even th...Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery
...radation until they reach their target and provide sustained release of drugs. Polymeric nanoparticles, however, suffer from one major limitation: they are quickly removed from the blood, sometimes in minutes, rendering them ineffective in delivering drugs. The research team, led by Samir Mitragotri, a profes......radation until they reach their target and provide sustained release of drugs. Polymeric nanoparticles, however, suffer from one major limitation: they are quickly removed from the blood, sometimes in minutes, rendering them ineffective in delivering drugs. The research team, led by Samir Mitragotri, a profes...2 MSU professors spearhead international water project
...ed States and abroad to ensure that the project is sustained after the NSF funding is over, he said....Gene therapy study shows safety and statistically significant improvement in Parkinson's disease
...o how brain cells communicate. The significant and sustained improvements in clinical symptoms following treatment of only one side of the brain are impressive. Moreover, the PET results offer an important window into the function of the living brain in these patients, which supports a normalization of brain a...UN issues analysis of global investors' sustainable energy 'gold rush'
...n total in the developing world. We will need many sustained steps towards the de-carbonizing of the global economy. It is clear that in respect to renewables those steps are getting underway. Says Yvo de Boer, Executive Secretary of the UN Convention on Climate Change: As governments prepare to launch a new...Remicade data in ankylosing spondylitis show improvement in spinal mobility and spinal inflammation
...ty. In addition, REMICADE-treated patients showed sustained reductions in spinal inflammation through two year...ement in MRI Activity scores at week 24, which was sustained through week 102 in those patients who continued in the trial extension (N=161). Patients initially...Latest data shows MabThera provides significant, sustained relief from symptoms of RA
...stressing symptoms of rheumatoid arthritis (RA) is sustained or further improved with subsequent courses of treatment, as is the number of patients achieving remission1. Importantly, the safety profile of MabThera remained unchanged in patients who had received as many as seven courses of treatment at 6-12 mo...