NIH gives $8M to University of Pittsburgh School of Medicine for myositis research
...dy doctors want to know whether rituximab improves symptoms of these diseases. Rituximab is a monoclonal an...r polymyositis. The study doctors believe that the symptoms of myositis are related to the presence of B cells in the blood and rituximab is being given to redu...Risk of common vaginal infection linked to preterm birth appears higher for blacks
...rmal bacteria. Among the infections more prominent symptoms is a milky, foul-smelling discharge. For years, clinicians have thought of BV infection as a minor problem, but in addition to increasing the risk for preterm birth, other studies have shown that women who have BV also are more likely to get herpes...High blood pressure, low energy -- a recipe for heart failure
...ort that mice born without any ERR alpha developed symptoms of heart failure when their hearts were forced to pump against high pressure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting outcomes suggest that heart health greatly depends on ERR alpha. "The...Genetic variation helps to understand predisposition to schizophrenia
...tions affect the function of this gene and lead to symptoms of schizophrenia. The researchers are now planning to investigate further the role of Neuregulin 1 type 4 in brain development and behavior and determine how various alterations of the Neuregulin 1 gene lead to schizophrenia. By better underst...Gilbert Foundation and American Fed for Aging Research award grants on Alzheimer's disease
...rmalizing this calcium defect can reduce the later symptoms of the disease. Alzheimer's disease is the most prevalent neurodegenerative disease affecting an estimated 26 million people worldwide, including 4.5 million Americans. Scientists predict that the prevalence of the disease will double for every f...Antioxidant overload may underlie a heritable human disease
...tallin, specifically in the heart develop the same symptoms seen in human patients, including heart enlargement, progressive heart failure, and an early death. They further show that the animals hearts are under reductive stress. The find initially took Benjamin by surprise, he said. They had conducted a te...New molecular regulators of hyperthyroidism and goiter
...ce had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In addition, the thyroid gland in these mice was unresponsive to the proliferative effects of TSH and a goitrogenic diet. The authors therefore suggest that inhibiting Gq and G11, or the molecules activated...JCI table of contents: Aug. 9, 2007
...ce had reduced thyroid gland function and many had symptoms similar to individuals with hypothyroidism. In addition, the thyroid gland in these mice was unresponsive to the proliferative effects of TSH and a goitrogenic diet. The authors therefore suggest that inhibiting Gq and G11, or the molecules activated...Gene variant is associated with brain anatomy, clinical course of ADHD
...udy demonstrates changes in cortical thickness and symptoms occurring in tandem, a future goal is to refine further our appreciation of cortical thickness by examining the links between this neuroanatomical variable and putative cognitive endophenotypes [invisible but measurable components on a disease pathwa...Gene predicts better outcome as cortex normalizes in teens with ADHD
...d more than half of them still had pronounced ADHD symptoms when followed-up about six years later, compared to only 21 percent of those with at least one copy of the 7-repeat variant. There was also a trend toward better overall functioning among those with at least one copy of the 7-repeat variant at follow...A low expression of MX2 gene exists in the white blood cells of narcoleptics
... of dreaming that occur while awake. Other common symptoms include sleep paralysis, hallucinations and cataplexy. About one out of every 2,000 people is known to have narcolepsy. The chance that you have narcolepsy is higher when a relative also has it. It is very rare for more than two people in the sam......s given to people within a day of exposure, before symptoms develop, can prevent illness and death. In mouse studies using DNA microarray technology, the U-M scientists were able to track which genes and enzymes play key roles in the bacterium that causes anthrax, while it sneaks inside the immune systems ...New databases put wings on search for bipolar risk genes
...rst of its kind, offering detailed descriptions of symptoms and course of disease on more than 5,000 people wi...e database will let researchers correlate specific symptoms with sequences of genetic material. The new database, available at http://www.hopkinsmedicine.org/...New UD tissue-engineering research focuses on vocal cords
...ural pliability, resulting in hoarseness and other symptoms of vocal dysfunction. The reduction of vocal-fold scarring remains a significant therapeutic challenge, Jia said. Jia and her colleagues want to explore two parallel tissue-engineering approaches to regenerate the lamina propria. One method focus...Geisinger scientist seeks cure for Lou Gehrig's disease, creating device to find treatment
...ho suffer from ALS. In the diseases early stage, symptoms may be so hard to detect that the disease gets overlooked. But by the end stages of the disease, the patients are totally paralyzed. ALS is a terrible disease, Gerhard says. Your brain is fine but your body and your muscles just waste away....Research teams uncover risk genes for multiple sclerosis
...S is a disease of the central nervous system whose symptoms range from mild muscle weakness to partial or complete paralysis. It is widely considered an autoimmune disease that arises from a combination of genetic and environmental factors. This collusion of events leads the body to attack and destroy the ins...Insulin grown in plants relieves diabetes in mice; UCF study holds promise for humans
...s could someday be used to prevent diabetes before symptoms appear and treat the disease in its later stages, Daniell said. He has since proposed using lettuce instead of tobacco to produce the insulin because that crop can be produced cheaply and avoids the negative stigma associated with tobacco. The Nati...First new multiple sclerosis gene found in 30 years
... in the bodys electrical system. This leads to the symptoms of the disease, which include muscle weakness, cognitive impairment, difficulties with balance and coordination, and speech and vision problems. What triggers this autoimmune response is likely a result of a complex interplay between genetic and envi...After a decades-long search, scientists identify new genetic risk factors for multiple sclerosis
...other. Various immunosuppressant drugs can reduce symptoms and slow the disease's course, but most MS patients become increasingly disabled with time. The trigger for MS is unclear, though there's strong evidence for an interplay between genetic susceptibility and some type of environmental factor. Having...... MS, a disease of the central nervous system whose symptoms range from mild muscle weakness to partial or complete paralysis, is widely considered an autoimmune disease, one that arises from a combination of genetic and environmental factors. This collusion of events leads the body to attack and destroy the i...