Next-era targeted therapy overcoming Gleevec's shortcomings
...cr-Abl protein. One such candidate drug is AMN107, synthesized by Novartis Pharmaceuticals in Basel, Switzerland, and characterized in collaboration with investigators at the Dana Farber Cancer Institute. In essence, AMN107 retains half the chemical makeup of Gleevec, while the other half was engineered to assu...NIH awards Georgia Tech/Emory $11.5 M for nano cardiology research
..."quencher" molecule at the other end. The ssDNA is synthesized to match a region on a specific messenger RNA (mRNA) that is unique to the gene. The fluorescence of the beacon is quenched, or suppressed, until it seeks out and binds to a complementary target mRNA, which causes the hairpin to open up and the beaco...PNAS highlights for the week of May 9 - 13
...eleasing factor (CRF) and urocortin II (UcnII) are synthesized in the small intestine to regulate inflammation, shedding light on diseases such as irritable bowel syndrome....For young canaries learning their song, freedom in youth gives way to rules in adulthood
...r occur in the repertoire of an adult canary. "We synthesized a song, using a computer, in which each sound is s...ll that a random walk," says Nottebohm. In another synthesized song each successive note was identical to the previous one except for a slight drop in pitch, a dow...Dietary supplement a potential treatment for Canavan disease
...synthesis deficiency causes CD. Analyses of newly synthesized lipids in the brain revealed significant decreases in four or five major myelin lipids in CD mice at the time of peak myelination. Acetate levels in the brain decreased by about 80% while acetate levels in the liver and kidney remained unchanged. Ana...Penn receives $9.5 mllion NIH grant to create center for molecular discovery
...es, collected and purified from natural sources or synthesized by chemists around the world, will be tested against biological targets for inhibitory or activating activity. The Penn center is one of nine facilities that the NIH is establishing across the country as part of the Molecular Library Screening Cente...Anthrax inhibitors identified by Burnham team
...ll-molecule inhibitors of LF. Lead compounds were synthesized and validated as highly potent and selective against LF in vitro. In in vitro assays, the compounds did not affect prototype human metalloproteinase enzymes that are structurally similar to LF. This is very important as selectivity is a fundamental ...Nerve protector could make for new stroke treatments
... A research team lead by the Burnham Institute has synthesized and tested a new series of inhibitors that can prevent the type of nerve cell injury and death associated with many neurodegenerative diseases and stroke. The study, led by Stuart Lipton, MD, PhD, professor and director of Burnham's Del E. Webb Cen...Hunt for human genes involved in cell division under way
... called 'RNA interference (RNAi)' where chemically synthesized RNA molecules are used to target and silence each ...e first use of a genome-wide library of chemically synthesized siRNAs in academic research and these partners have provided us with the tools to carry out this sea...Endocannabinoids the brain's cannabis demonstrate novel modes of action to stress
...in and oxytocin are synthesized. They found that a synthesized cannbinoid (CP55,940) inhibited both excitatory and inhibitory synaptic transmission and that a balanced input can produce sustained changes in neuronal activity without damage to neuronal homeostasis. "Our next step is to investigate cannabinoids' e...Using nanoparticles, in vivo gene therapy activates brain stem cells
... the nanoparticles developed by the UB team can be synthesized easily in a matter of days by an experienced chemist. The UB researchers make their nanoparticles from hybrid, organically modified silica (ORMOSIL), the structure and composition of which allow for the development of an extensive library of t...Toxins drove evolution of human taste sense, global study reveals
...comprise a wide class of natural defense compounds synthesized by over 2,500 plant and insect species. Glucopyranosides are present in various foods items, including cassava, almonds, green tea and some beans. The researchers identified six common variants of the TAS2R16 bitter receptor, two of which alter the r...New molecule may aid in production of biofuels and fungi-resistant plants
... the Norwegian University of Life Sciences. "It is synthesized by different crustaceans, mollusks, algae, insects, fungi and yeasts and is a major structural component of these organisms. For example, chitin gives strength and stiffness to the shells/cuticles of shrimps and insects and to the cell walls of fungi...Nobel Laureates solve 72 year old, dietary cholesterol puzzle
...trated when Rudolph Shoenheimer observed that mice synthesized large amounts of cholesterol when fed a low-cholesterol diet, but this synthesis stopped when the mice were fed cholesterol. In later years, many details of this cholesterol feedback were worked out, but the main mechanism by which cells in the liv...JCI table of contents September 1, 2005
...trated when Rudolph Shoenheimer observed that mice synthesized large amounts of cholesterol when fed a low-cholesterol diet, but this synthesis stopped when the mice were fed cholesterol. In later years, many details of this cholesterol feedback were worked out, but the main mechanism by which cells in the liv...University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
...lar to those from other insect species. These were synthesized at the University of Nevada, Reno then sent to London to study their effects on mosquitoes. When a mosquito sucks blood from a human--and only pregnant female mosquitoes do this--it will take in twice its body weight in blood. To decrease this added ...Harmless virus may hold key to more effective HIV drug discovery
...artment of Chemistry, who together with co-workers synthesized the small-molecules used in the study. New anti-HIV compounds are being tested by Dr. W. Ed Robinson, Jr. in the Department of Pathology. Weiss and Olszewski have made their method freely available to the scientific research community. Olszewski is ...VCU research: Magnetic nanoparticles for potential cancer treatment
...erial but also to the way in which the material is synthesized and processed." Today, polymer encapsulated iron oxide particles are used in biomedical applications. However, Carpenter said that the high magnetization of the enhanced ferrite nanoparticles may potentially improve the absorption of the radio freq...Researchers find drug that blocks spread of lung cancer in mice
...nt begins in most cases. The researchers designed, synthesized and tested GRN163L, which consists of 13 nucleotides, the units that make up DNA, plus a fatty section that improves the rate at which cells take it in. GRN163L specifically matches a stretch of DNA at the end of the chromosome, a segment called the......cause melanin - a coating of black pigment - to be synthesized and deposited on the surface of the pathogen. The goal of their research is to understand how insects recognize infection caused by microorganisms such as viruses, bacteria and fungi, and the pathway of reactions that follow in the immune system. Stu...