Tag: "target" at biology news
Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
...relevance of the NF-κB signaling pathway as a target
for MM therapy. MM is a cancer of the plasma cel...pathway as a key event in MM pathology. NF-κB target
genes are known to be involved in cell proliferation and cell survival. Although there is significan...
Invasion of the brain tumors
...receptor and suggest it may be a novel therapeutic target
in the treatment of this devastating cancer. ...
Bursts of waves drive immune system 'soldiers' toward invaders
...t plays a role in heart attack - another promising target
for applying the new insights of the regulation of cell movement, the authors say. White blood cells, or neutrophils, are the body's first line of defense against potentially harmful microbes, and are one of the swiftest cells in the body. The wav...
High blood pressure, low energy -- a recipe for heart failure
...e activated with small compounds, making it a good target
for drugs." ...
ESF EURYI award winner aims to stop cancer cells reading their own DNA
...k is aiming towards a new generation of drugs that target
cancer cells much more specifically than tradition...orks normally, but in cancer cells it is a natural target
for disruptive therapy. Specifically targeting these molecular motors in cancer cells would then pre...
deCODE discovers cause of major subtype of glaucoma
...hat causes XFG, providing a promising mechanism to target
for developing therapy. We plan to conduct additional studies to examine how we can take advantage of this finding to begin drug discovery, said Kari Stefansson, CEO of deCODE. The deCODE team discovered the variants by first analyzing more than ...
Genetic variation helps to understand predisposition to schizophrenia
...ovel protein works in the brain, we may be able to target
it in people with the disease. The researchers showed that the genetic change that causes overproduction of Neuregulin 1 type 4 is part of a DNA sequence called a promoter, which enables genes to be coded for proteins. A protein called a transcrip...
Brain blood flow gives clues to treating depression
...different classes of antidepressant medicines that target
different neurotransmitters is associated with a similar improvement in cerebral blood flow, he noted. However, cerebral blood flow continued to deteriorate in patients who responded to electroconvulsive therapy, added Bonne, who helped implement fun...
Secret life of elephant seals not secret anymore!
...alinity collected by the seals show that the seals target
very specific water bodies, Dr Rintoul said. An intriguing surprise was that the feeding preferences of the Atlantic seals were very different from seals tagged on Kerguelen and Macquarie Islands, in the Indian and Pacific sectors of the Southern O...
Cornell scientists link E. coli bacteria to Crohn's disease
...up adopted a broad culture-independent approach to target
specific subgroups of bacteria for quantitative in situ analysis and culture based characterization, said Kenneth Simpson, professor of small animal medicine at the College of Veterinary Medicine. Our findings raise the possibility that a novel group...
Penn researchers discover how key protein stops inflammation
... inflammatory diseases. Current drug treatments target
inflammation signaling pathways. When you inhibit ...Bcl-3 acts on specific genes, we should be able to target
a subset of dangerous regulatory genes without disrupting other important immune responses. Such dru...
Link identified between Alzheimer's disease and glaucoma
...drugs being trialled for Alzheimer's disease which target
this protein may be used to treat glaucoma. The ...se damaged retina to screen Alzheimer's drugs that target
beta-amyloid build up."...
Defects in critical gene lead to accelerated lung tumor growth
...is to their patients, as well as giving them a new target
for future therapies, Sharpless said. The stud...sions depending on which therapy is most likely to target
that defect. Currently, Hayes and his colleagues are looking at cancer progression in patients fro...
Improved NIST SRM aids lead poisoning detection
... even lower lead blood level than that of the 2010 target
among children younger than 72 months. SRM 955c is packaged as four vials of frozen blood at four progressively elevated lead concentration levels. Unlike previous issues of SRM 955 that were based on hog or cattle blood, SRM 955c is based on bloo...
Identified mechanism in the malaria parasite to help it adapt to infected individuals
...s are a possible weak point, and thus a very clear target
to develop vaccines. Alfred Corts, an ICREA researcher working at IRB Barcelona and an expert in molecular parasitology, together with researchers from the National Institute for Medical Research (NIMR) in London, have discovered that the parasite ha...
Phase II study of therapeutic vaccine shows efficacy in patients with metastatic colorectal cancer
...y, enhancing the immune response to tumors. The target
of this immuno-therapy approach is a tumor antigen called 5T4, a protein embedded within the membrane of cancer cells. The protein is rarely found in normal tissues, but is produced at high levels by a wide range of human cancers, including colorecta...
Taming the anthrax threat
...g cells), Bergman says. New drugs, he says, should target
the bug during the brief window of vulnerability when the bacteria transform from dormant spores into active, growing organisms. That chance exists for a few hours when the invaders are inside immune cells in the lung and then pass from the lungs to ...
Cost-effective method for gene silencing is featured in Cold Spring Harbor Protocols
...ing silencing RNAs, called esiRNAs, to efficiently target
virtually any gene in mammalian cells. The protocol ( http://www.cshprotocols.org/cgi/content/full/2007/16/pdb.prot4824 ) describes how to enzymatically generate RNA molecules in vitro, using the cloned gene of interest as a template. The RNA mole...
Gold nanoparticles may pan out as tool for cancer diagnosis
...e fabricated so that their size is unique to their target
marker. That way, when nanorods bind to their mark... to the nanorod's dimensions, its antibody and the target
cancer marker, which must be present for binding to occur. More than 200,000 women are diagnosed w...
Under magnetic force, nanoparticles may deliver gene therapy
... vehicle for delivering drugs, genes or cells to a target
organ. This is a novel delivery system, the first ...could use magnetic forces to direct the cells to a target
organ. Furthermore, researchers might deliver nanoparticles to magnetically responsive, removable...
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