Tag: "target" at biology news
New understanding of schizophrenia could lead to new treatment approaches
...n known to be altered in schizophrenia, and is the target
of many antipsychotic drugs. "Changing the white matter in the brain apparently unbalanced the dopamine system, something that also occurs in patients with neuropsychiatric disorders," says Corfas. Finally, mice whose NRG1-erbB signaling was bl...
A relative of anti-aging gene Klotho also influences metabolic activity, obesity
...ose levels in fat cells of mice, making it a novel target
for developing drugs to treat human obesity and di...s Klotho protein, known as beta-Klotho, is a novel target
for developing drugs that can enhance or block the metabolic activity of this hormone, which has bee...
Deactivating protein may protect nerve fibers in MS
...ts are eyeing a protein as a potential therapeutic target
for multiple sclerosis because de-activating it pr...ive years. "We don't have to invent the drugs to target
this protein. They already exist," Bourdette said. Such a therapy can't come soon enough for 36-ye...
Study links faulty DNA repair to Huntington's disease onset
...rray. The study suggests that OGG1 might offer a target
for the development of new Huntingtons disease treatments. McMurrays team is already pursuing this path and is screening for small molecules that block OGG1 function. This work may also be relevant to research on other diseases, such as Alzheimers an...
Susceptibility to Crohn's disease -- an important new clue
...ing the way towards personalized medicine and drug target
Knocking out survival protein could aid leukemia treatment
...findings demonstrate that Mcl1 may be an effective target
for drugs directed against CLL and ALL," says principal investigator John C. Byrd, professor of internal medicine and director of the hematologic malignancies program at Ohio State's James Cancer Hospital and Solove Research Institute. "These resu...
JCI table of contents -- April 19, 2007
...drugs that are known as beta-blockers because they target
proteins known as beta-adrenergic receptors (beta-...MUNITY Autoantibodies help T cells "see" their target
Autoimmune diseases such as type I diabetes and rheumatoid arthritis are caused by the immune sys...
Discoveries thrust cancer-initiating stem cells into a larger role in cancer biology and treatment
...tem cells are examined as the cause and potential target
of treatment for many, if not all, cancers. At th...newal is important in developing therapeutics that target
the tumor stem cell pool. These genes might also become targets of interest in the treatment of tumo...
Researchers identify key gene that may be a marker of breast cancer metastasis
... important biomarker for metastasis and a possible target
for novel treatments for patients with metastatic breast cancer....
OHSU lab finds meth receptor that could lead to therapy
... found. The signaling system could soon become a target
for therapies aiming to reverse meths adverse heal... and Pharmacology, scientists demonstrated the new target
of meth, and its close relative amphetamine, is a G protein-coupled receptor known as trace amine-as...
Genes and biomarkers that allow doctors to choose the right therapy for the right patient
...ailor existing therapies to individuals and how to target
experimental agents." Gray and his colleagues ha...ticular recipient, Mousses said. To search for target
genes that regulate Tykerb response, Mousses and his colleagues performed a genome-scale scan of two...
News tips from the Journal of Neuroscience
...occurring antagonists, which are in themselves FGF target
genes. This pattern creates feedback regulation of FGF signaling. Abraira et al. examined the effect of one of these antagonists, Sef, on cochlear development. Sef antagonizes the MAP (microtubule-associated protein) kinase pathway that is induced by...
Biologists prove critical step in membrane fusion
...mbrane-bound drugs can be induced to hemifuse with target
cells rather than fully fuse there is the potential to control the timing of drug delivery....
Stem cells provide new tool for studying disease and identifying ALS drugs
...arly diagnosis of the disease but also provides a target
for potential new therapies aimed at slowing motor neuron degeneration in ALS. "That's what happens when scientists from major institutions work together toward shared goals. Project A.L.S. prides itself on building productive research teams from ...
Research director to be honored at international congress
...el small and large drug molecule design; molecular target
identification for cancer therapy, infection control and regenerative medicine; stem cell and tissue engineering technologies for therapy and laboratory models of human tissue; and mathematical and computational modeling of molecules, cells and tissu...
Progress toward a targeted therapy for a specific form of leukemia
... has indicated that MYB might well be an important target
for therapies for this group of T-ALL patients. ...archers are convinced that MYB can be an important target
for the development of a new therapy for T-ALL. They are particularly encouraged by the results they...
Enhancing chemotherapy's efficacy: New agent has synergistic effect with standard drugs
... of new cancer drugs in development such as MCP110 target
this pathway to inhibit one or more steps in the g...rapies may use two drugs that either have the same target
or two different targets. Another approachthe one we've taken hereis to combine a pathway-targeted ...
Health disparities -- Genetics, society and race play an important role in access to healthcare
...sh." The results, Hamilton said, may help better target
disease intervention programs for those most vulnerable and at risk. The Effect of Hospital and Physician Volume on Racial Differences in Disease Recurrence Following Surgery for Prostate Cancer: Abstract 3416 Epidemiologists have unexpectedly ...
MicroRNAs as tumor suppressors
...origenesis. This paper establishes that HMGA2 is a target
of let-7, and that the let-7 microRNA functions as a tumor suppressor to prevent cancer formation in healthy cells....
Blame the brain for high blood pressure
...rain, so that we know what drug to use, and how to target
them. JAM-1 could provide us with new clues as to how to deal with this disease. Professor Jeremy Pearson, Associate Medical Director of the British Heart Foundation, commented: This exciting study is important because it suggests there are unexpe...
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