Scientists take next step in understanding potential target for ovarian cancer treatment
...and that the km23 protein itself may be a possible target for cancer therapies. km23 is part of the signaling system for a growth factor called TGF, which attaches to TGF receptors at the cell membrane. It activates km23 into action. km23 acts like a traffic cop for specific proteins as they move in t...A decisive step toward a cure for insulin dependent diabetes
...w design highly specific drugs that will precisely target the effects of the defective gene. These treatments, combined with a stem cells regeneration therapy, will relieve patients of all symptoms of diabetes. Dr. Polychronakos notes, While this prospect is still far off, it is realistic, and this study is......ersity Medical Center have identified IL6 as a new target in the battle against Ras-induced cancers. Ras i...d lung cancer. Unfortunately, though, attempts to target Ras for inhibition in a clinical setting have proved unsuccessful. "We knew Ras was really importa...JCI table of contents: July 12, 2007
... The clot thickens: protein interaction is a drug target for blood clot prevention After a blood vessel in injured, platelets cluster together to plug the site of injury in the form of a blood clot (thrombus). In arterial disease, altered platelet aggregation can block blood vessels and cause heart atta...Antibody retards growth and induces death in liver cancer cells
...est that PDGFR offers an important new therapeutic target for the treatment of HCC. We are very excited because this is the first targeted therapy for liver cancer. Other therapies have some modest benefits, but no one knows exactly how they work. We now have identified a pathway that appears to be overl...Researchers use new approach to predict protein function
...kely to bind to any of a vast library of potential target molecules, or substrates. Determining which substrate binds to a given protein is vital to understanding the proteins function. This study describes an integrated approach using experimental techniques, computational techniques and X-ray crystallog...New use for a cell toxin found to inhibit survival proteins in cancer cells
... express Bcl-2 proteins. Higher expression of the target protein made cells more sensitive to the 2-Methoxy antimycin inhibitor. This is called a gain of function mechanism and is counterintuitive to the way most drugs work. Our compound, 2-Methoxy antimycin, is the only Bcl-2 inhibitor reported with gai......activity (facilitation of miRNA-guided cleavage of target mRNA). However, as Drs. Donal OCarroll and Alexander Tarakhovsky (The Rockefeller Institute) report in an upcoming issue of G&D, Ago2s defining characteristic is surprisingly non-essential for its role in hematopoiesis and miRNA biogenesis. An a...Modified herpes virus keeps arteries 'free-flowing' following procedures
... treated with the herpes virus. The ability to target the smooth muscle cells that cause the narrowing, and regenerate the endothelial cell lining is an important finding, noted Skelly. This study is an important step in the application of genetically engineered herpes simplex viruses for treatment...Nearly 90 percent of babies receive recommended newborn screening tests
...ements. The snapshot shows that the nation is on target to meet the March of Dimes goal of having all babies screened for 20 or more of the recommended panel of genetic disorders by 2008. Federal Advocacy Efforts The March of Dimes supports two pieces of federal legislation, the Newborn Screening Sav...Other highlights from the July 10 JNCI
...erapy Drugs A gene known as HDAC1 may be a good target for drugs to treat multidrug-resistant neuroblastoma, a cancer that develops in immature nerve cells and is prevalent in children. Drug resistance could explain why about 50% of high-risk neuroblastoma patients die of the disease. Nino Keshelava, ...MIT, BU team builds viruses to combat harmful 'biofilms'
...believe that many more could be custom-designed to target different species or strains of bacteria. The wo...r system that allows engineers to design phages to target specific biofilms. As a proof of concept, they used their strategy to engineer T7, an Escherichia co...Scientists identify 2 distinct Parkinson's networks
...ng to alter these networks and we need new ones to target these symptoms. He said that the networks could be used as biomarkers to diagnose the disease. The scientists have also developed mathematical computer models to determine how fast the disease will progress. These scanning techniques may be helpfu...Scientists follow familiar TRAIL to new cancer therapy
...eath receptor signaling an attractive and exciting target for cancer therapy, and it is currently being tested in clinical trials. However, most cancer cells have defects in their ability to die via a cell death pathway called apoptosis, and unfortunately, TRAIL therapy is not effective in cells that have c...A gene that protects from kidney disease
...ve already identified one promising candidate drug target and our mouse model will help us find many others....Tracing Parkinson's lethal mechanism
...es in neurons and modulating a relevant downstream target rather than Cdk5 directly may be a better therapeutic strategy with regard to this pathway. ...New 'asthma gene' could lead to new therapies
... biology and we know the players, it's possible to target with specific drugs." Childhood asthma treatments are heavily focused on allergic responses, since most children with asthma also have many allergies. The discovery of a so-called 'asthma gene' would provide a new set of mechanisms to try and modif...Today's waste, tomorrow's fuel
...le ways to re-use this finite resource. One prime target is the waste containers in road-sweepers. The research collaboration is also exploring how food wastes, and friendly bacteria can be used to create greener energy. Their goal is to see these techniques being applied to produce clean fuel cells t...Waging war on the deadliest superbug
... developed the ClosTron knock out system which can target specific genes in C. diff and other clostridial sp...by the spores of harmless clostridial species that target the cancer tissue; (ii) more effectively controlling the food borne bacterium C. botulinum, and (iii...American Chemical Society's Weekly PressPac -- June 27/July 3, 2007
...anorods to monoclonal antibodies that specifically target cancer cells, may mean a promising new approach to early detection of cancer, the report states. ARTICLE #5 High Sensitivity of In Vivo Detection of Gold Nanorods Using a Laser Optoacoustic Imaging System DOWNLOAD PDF http://pubs.acs.org/cgi-bin/s...