Insignia -- A new way to identify viruses and bacteria
...d to rapidly compute signatures for any particular target species. The program can have a wide range of applications, from diagnosing infections in humans to detecting harmful microbes in a water supply. To maximize its use by scientists in a variety of disciplines, Insignia is freely available on the autho...Combining NSAIDs with chemotherapy, radiation may improve cancer treatment
...f cells in S phase suggests this class of drug may target the radio-resistant cells, and use of the drug together with radiation might provide better tumor control than radiation alone. Because inflammation is thought to play a role in the development of certain cancers, numerous studies have investigated...Newly identified mechanism for silencing genes points to possible anti-cancer strategies
...nces against particular messenger RNA sequences to target them for destruction," explains Ramin Shiekhattar, Ph.D., a professor"in the Gene Expression and Regulation Program and the Molecular and Cellular Oncogenesis Program at Wistar and senior author on the new study. "Thats one way we know that microRNAs...New study examines 'brain's own marijuana'
...nxiety. An alternative strategy may be to directly target the brains own marijuana. The success of such a strategy requires a better understanding of how endocannabinoid moderates stress-related behaviors and how stress and stress hormones activate the endocannabinoid system. Haj-Dahmane and his co-investi...Soy estrogens and breast cancer: Researcher offers overview
...nterferes with treatments, such as tamoxifen, that target estrogen receptors in breast tumors. (About 70 percent of women with breast cancer have estrogen-responsive tumors.) "The resolution of this paradox may lie in the timing of estrogen administration," Helferich said. Exposure to genistein, an estrog...Pediatric cancer stem cell identified: understanding the origin of ERMS
...nd progression, effective long-term therapies must target the self-renewing population of cancer stem cells. The zebrafish is ideally suited for use in targeted chemical genetic approaches to specifically inactivate cancer pathways we have identified in our study. Identifying drugs that inactivate these p...Getting to the core of an emergent public health threat
...ntly prevent infection. Another important viral target of Hogues research is the role of the coronavirus envelope protein (E protein), described in "Role of the Coronavirus E Viroporin Protein Transmembrane Domain in Virus Assembly," Journal of Virology (April 2007). By creating mutants of the E protein...Other highlights in the May 16 JNCI
...static cancer cells from dying and could be a good target for drug development. Unlike normal cells, meta...lts raise the possibility that FLIP is a potential target for novel anticancer therapies," the authors write. Contact: Jane Finlayson, senior public affair...Subtle signs can help predict Huntington's disease early
...f Medicine in Iowa City. "Ideally, treatments will target at-risk people at or before the earliest stages of the disease, before they have any problems with thinking or movement." The study involved 218 people in North America, Europe and Australia considered at risk for Huntington's disease because they ...NYU's Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
...earchers found that one-third of C. elegans miRNAs target gene sets have related functions. That is, it appe...reporter, green fluorescent protein (GFP) carrying target 3 UTRs with controls that did not carry the target 3UTRs. The laboratory results confirmed the role ...DNA sieve -- Nanoscale pores can be tiny analysis labs
...ves ionizing and disintegrating large numbers of a target molecule, then analyzing the masses of the resulting molecules to produce a "molecular fingerprint" for the original sample. This equipment can cover a good-sized desk. By contrast, the "single-molecule mass spectrometry" system described in the PNAS...Climate policy: It's good to be in the 'RED'
...ns needed from all carbon sources to meet the IPCC target of 450 parts per million of carbon dioxide in the atmosphere by the year 2100. As for the second issue, computer models that link climate effects to changes in the carbon cycle have predicted that tropical forests will survive and continue to act a...UF scientists identify cancer virus' genetic targets
... this case all of the viral microRNAs were used to target 34 different binding sites on the human gene, so apparently this is a virus that really wants to down-regulate thrombospondin." In some people Kaposis sarcoma virus technically its in the family of herpesviruses causes patches of cancerous tissue...Landmark study identifies large number of new proteins implicated in Huntington's disease
...roteins," said Hughes. "Effective follow-up on any target protein depends, in large part, on how much expertise a scientist has with that target. We are hoping that researchers will look at this study and that those with specific expertise in a particular protein will move forward with their own inquiries."...Molecule that destroys bone also protects it, new research shows
...nflammation in autoimmune diseases. Therapies that target IL-17 or its cellular receptor currently are being...ut also because the consequences of therapies that target these cytokines need to be understood."...Genetic roots of bipolar disorder revealed by first genome-wide study of illness
...a very few years ago. We now have a new molecular target scientists can investigate in their search for bet...be better prevented or treated. "Treatments that target just a few of these genes or the proteins they make could yield substantial benefits for patients. ...BEMA Fentanyl demonstrates substantial transmucosal delivery
... the commercial value for BEMA Fentanyl remains on target with our expectations. In addition, we believe these continued positive findings with our BEMA technology lend support to the continued development of other products in the technology, including our next pain product in development, BEMA LA."...Healthy reefs hit hardest by warmer temperatures
...le. During the study, the researchers monitored target reefs for white syndrome, which infects Pacific reef-building corals. The disease results in a white band of tissue or exposed coral skeleton that moves across a colony as infection progresses. (White isnt the only color of diseased coral other synd...Nitric oxide: Key to cardiovascular and pulmonary function and drug effectiveness
...ay, as well as many hormone and neurotransmitters, target a specific family of cell surface receptors known as G-protein coupled receptors. The researchers believe that the presence or absence of nitric oxide or SNOs determines whether these receptors continue to function properly. This action is controlled......ard to control experimentally. Birds are an easier target for research and indeed, they also have different personalities. An international team of researchers have now found evidence for the existence of a "curiosity-gene" in a songbird, the great tit (Parus major). The gene (Drd4) carries the building ins...