Scientists a step closer to understanding how anaesthetics work in the brain
...esirable effects could lead to much more specific, targeted alternatives being developed, which could greatly reduce these problems, he said....Charting ever-changing genomes
...Science. It reveals the regions that are currently targeted by natural selection or have been so during the evolutionary past. In an independent study the collaborators -- this time led by Detlef Weigel, Ph.D., director of the Max Planck Institute for Developmental Biology in Tbingen, Germany, and an adjunc...Gene identified for Crohn's disease in children
...oms. Understanding gene influences gives us a more targeted way to look at disease physiology, and also may suggest targets for treatment. Baldassano and Hakonarson said that they will continue to search for other gene variants associated with Crohns disease and the closely related bowel disorder ulcerative c...Gene discovered for type 1 diabetes in children
... diabetes, we hope to intervene early in life with targeted drugs or cell therapies to prevent the disease from developing, said Polychronakos. The current research used a technique called genome-wide association, in which highly automated analytic equipment rapidly scans each patients DNA for more than ha......ch is needed to determine the effectiveness of IL6 targeted cancer therapies, these initial results are encouraging. "Targeting secreted proteins that Ras activates has opened the door to inhibit the oncogenic signal of Ras via druggable proteins," states Dr. Counter...EPA foregoes opportunity to improve nanotechnology oversight
...on, second generation usesin electronics, sensors, targeted drugs and active nanostructureshave already begun. In May 2007, Davies authored the first in-depth analysis of EPAs nano-tech readiness, EPA and Nanotechnology: Oversight for the 21st Century. This Project on Emerging Nanotechnologies report is av...Major breakthrough in understanding how HIV interferes with infected cell division
...m have identified a novel cellular protein complex targeted by HIV-1 Vpr to stop infected cell division. This protein complex, designated DDB1-CUL4-VprBP, is involved in a process called ubiquitination. Ubiquitination is a mechanism by which a small protein called ubiquitin is conjugated to cellular proteins ...Small molecules may explain psoriasis
...in the future become more effective than medicines targeted at individual proteins. We believe that microRNA may also be significant in regulating other common chronic inflammatory diseases such as arthritis and certain autoimmune diseases, says Andor Pivarcsi, who has directed the study together with Enik ...Antibody retards growth and induces death in liver cancer cells
...liver cancer cell lines with a monoclonal antibody targeted against PDGFR. It resulted in a significant decrea.... We are very excited because this is the first targeted therapy for liver cancer. Other therapies have some modest benefits, but no one knows exactly how th...New use for a cell toxin found to inhibit survival proteins in cancer cells
...combination with other agents, and could lead to a targeted molecular therapy to enhance the effectiveness of cancer treatments. Hockenbery said his groups approach illustrated the need to look at how the proteins interact with everything else in the cell. By over expressing this protein, the cell is changed ...Other highlights from the July 10 JNCI
...er Targeted Cancer Drugs Using Ultrasound A new targeted drug delivery method uses ultrasound to image tumo...nanobubbles into the tumor. Cancer drugs can be targeted to tumors by delivering them in packets of nanoparticles, then releasing them with ultrasound. But t...Invisible gases form most organic haze in urban, rural areas
...hether we could improve air quality if we directly targeted VOC emissions and not just particle emissions," said Zhang. "Until we understand the breakdown between human-caused and natural VOC emissions, and between different human sources, we won't have an answer to that question." ...Researchers identify genetic mutation that may alter tumor cell proliferation
...bers of this pathway are among the most frequently targeted for new cancer drug discovery efforts. Activation ...luable tool for the stratification of patients for targeted therapies. This paradigm of identifying specific defects in cancer cells to successfully develop inn...JCI Table of Contents -- July 2, 2007
...rchers have long asked why only certain organs are targeted in autoimmune disease. In so-called NOD mice (an animal model of type 1 diabetes) T and B cells that infiltrate the pancreatic islets have been shown to target insulin B chain amino acids 923 (insulin B:923), and NOD mice lacking insulin B:923 are ...Glimmer of hope for Tahitian tree snails' survival
... publication. The findings offer renewed hope that targeted conservation measures may yet preserve a representative, although impoverished, fraction of Tahitis endemic tree snail genetic diversity in the wilda feat earlier believed to be impossible. The Society Islands were a biodiversity hot spot for tree ...M. D. Anderson team identifies new oncogene for brain cancer
...s IGFBP2 an important candidate for development of targeted therapy to treat gliomas, Zhang says. Gliomas kil...lly reduce side effects caused by a treatment that targeted the gene or its protein product. Fuller and Zhang first associated overexpression of the gene with...Cell receptor may lead to new 'biomarker' for pancreatic cancer
...effect on pancreatic cell growth, blocking it with targeted antibodies killed more cancer cells than did the standard treatment drug gemcitabine (gem-SITE-uh-bean) alone. Our findings suggest that combining antibodies that block the RON receptor and the standard chemotherapy drugs might stop progression of......F) as a key factor in heart damage. And antibodies targeted to MIF, so-called anti-MIF antibodies, significantly improves cardiac performance during septic shock. MIF levels are also two times higher in autoimmune diseases like rheumatoid arthritis and diabetes. In the laboratory, Al-Abed and his colleague...SNM initiatives supported by inclusions in NAS Report on competitiveness of US chemistry research
...ne practice and radioisotope R&D needed to advance targeted molecular therapy and other radioisotope needs for the future. The results of a separate NAS study that is reviewing the state of the science for nuclear medicinea multidisciplinary science and medical specialty that uses radiopharmaceutical agents......ing biomass to energy and precision "vehicles" for targeted drug delivery. The research, which was conducted at the U.S. Department of Energy's Brookhaven National Laboratory, will be published in the July 2, 2007 issue of the journal Angewandte Chemie. "Our study demonstrates that nanoparticles are appea...