Support for chromosomal theory of cancer found in cancers' development of drug resistance
... resistance suggests that imatinib is not a highly targeted drug, as advertised, but just another cell "poison" that happens to kill more leukemia cells than normal cells. Development of drug resistance in cancer is one of the strongest arguments for the aneuploidy, or chromosomal, theory of cancer, Duesber...Damon Runyon names new class of rising stars in cancer research
...reast cancer patients with the goal of designing a targeted immunotherapy....Other highlights in JNCI, June 26
... to more efficiently evaluate the effectiveness of targeted therapies. Many cancer drugs that target specific molecules only benefit a subset of patients who have high enough levels of the target molecule. Often, though, phase III clinical trials are designed without knowledge of this threshold, so the tria...Nanoparticles carry chemotherapy drug deeper into solid tumors
... In the past, similar drug carriers have improved targeted delivery of the drugs and reduced toxicity, but they sometimes decreased the drugs ability to kill the tumor cells. Using a new drug carrier, Ning Tang of the Chinese Academy of Sciences in Beijing and colleagues compared tumor growth and survival in...Neuroblastoma expert reviews progress and challenges in fighting difficult pediatric cancer
...the tumors growth process. These approaches are targeted therapies--aimed in highly selective ways at cancer cells, but sparing healthy cells, said Maris. But in order to best guide us to the most appropriate treatments, we need greater understanding of the abnormal biological events that give rise to neur...Gene therapy study shows safety and statistically significant improvement in Parkinson's disease
...as not likely due to the surgical lesioning of the targeted brain region, as surgical approaches typically give rise to immediate, short-lasting benefit around the time of surgery, while prior studies of AAV-mediated gene therapy show that gene expression gradually increases to a maximal level over a period o...Study identifies 5 genetic themes key to keeping stem cells in a primitive, flexible state
...o disease. This may ultimately allow us to develop targeted therapies to stimulate adult stem cells within our own bodies to repair damaged tissues, and may provide further areas of exploration for the treatment of cancer....UVa researchers restore genes in human inner ear cells
... Kesser, an assistant professor of otolaryngology, targeted a gene known as KCNQ4, which causes genetic hearing loss in humans when mutated. They engineered a correct form of the gene and created a gene therapy delivery system that successfully transferred the KCNQ4 gene into human hair cells harvested from t...Small, self-controlled planes combine plant pathology and engineering
...isease, and mitigating potentially damaging events targeted at our nations agriculture and food supply....Physicist cracks women's random but always lucky choice of X chromosome
...has more chance of surviving any biological threat targeted at a single version of the X chromosome....U-M researchers discover gene switched off in cancer can be turned on
...r Center. The finding could lead to a new class of targeted cancer therapies with potential to benefit many di...to existing drugs, Reisman says. The researchers targeted lung cancer cell lines in particular, although they found similar results in a variety of other canc...Researchers shed light on mechanism of action used by anti-cancer drug
...ens in which it is combined with other molecularly targeted agents for patients with blood cancers and solid t... this agent might be logically combined with other targeted agents whose antitumor activity is limited by Mcl-1 expression, Grant said. Several such targeted ag...Super fruit fly may lead to healthier humans
...normal development, Roberts said. It is the most targeted family of receptors by drug manufacturers, Robertssaid, estimating that a quarter of all pharmaceuticals focus on GPCRs. This approach should be generally applicable. And generally powerful, given that GPCRs are notoriously unstable anddifficult ...A first: Simultaneous PET/MR images of the brain debut, increase molecular imaging capabilities
...ry small amounts of radioactive materials that are targeted to specific organs, bones or tissues. Radiotracers (such as FDG) are injected and then detected by a special type of camera that works with computers to provide precise pictures of the area of the body being imaged and molecular images of the body's ...Michael R. Zalutsky receives SNM's 2007 Paul C. Aebersold Award
...lonal antibodies; for contributing to the field of targeted radiotherapeutics, particularly those labeled with... the National Cancer Institute for his research in targeted radiotherapy. Zalutskys primary research interests are the development of molecularly targeted radio...Genomic signatures identify targeted therapies for lung cancer
...pproach to those patients, and that is where these targeted therapeutics come in." Potti and colleagues pres...cancer responded to treatment with the appropriate targeted therapy. Targeted therapeutics such as this could be "smart bombs" in comparison to the standard ...Cells re-energize to come back from the brink of death
...that program to kill the cell. Such a specifically targeted drug might be more effective and less toxic than standard chemotherapy. A report on this work is in the June 1 issue of Cell. Apoptosis is triggered by a variety of factors, including gene mutations that can make the cell become cancerous. During a...Gene therapy offers new hope for treatment of peripheral neuropathy
... managing this condition. It also is our hope that targeted transgene delivery of GlyR may have even broader implications for managing a number of chronic pain syndromes, including pain resulting from shingles, arthritis and cancer," explained Dr. Glorioso. ...2 million dwarfism study launched
... in every 10,000 children. Other disorders to be targeted include pseudoachondroplasia and spondyloepiphyseal dysplasia congenita, which both manifest with severe arthritis in adulthood. In the shorter term our research will help in the better diagnosis and prognosis of these disorders, said Dr Briggs. Ho......ived a unilateral intrastriatal 6-OHDA lesion that targeted dorsal striatum. The authors studied those animals that displayed motor deficits as revealed by amphetamine-induced rotation, cylinder, and stepping tests. Half of the rats received fetal ventral mesencephalon cell transplants, after which motor perf...