How plague-causing bacteria disarm host defense
...g bacteria. "The question now becomes, why is Gaq targeted by YpkA"" ...Analysis reveals extent of DNA repair army
...ve a better idea of how the BRCA1 protein is being targeted to DNA damage sites," Elledge said, and this seems to run a pretty big part of the BRCA1 program." The proteins, known as Abraxas and RAP80, bind to the BRCA1 protein and form a complex that governs three essential modes of DNA damage control: damage...JCI table of contents: May 24, 2007
...hh. Cobourne and colleagues found that mice with a targeted Gas1 deletion had underdeveloped faces, fused teeth, cleft palates, and severe ear defects, however their forebrains remained intact. These effects were associated with a partial loss of Shh signaling, suggesting that Gas1 is involved in Shh signalin...A close-up on pancreatic disease: How do we improve the odds?
...stoperative Patient Survival (Abstract #964) As targeted therapies become more reliable, researchers are searching for additional prognostic factors as therapeutic targets, with the concept of tailoring therapies to patients who will respond better to certain regimens. Epidermal growth factor receptor (or...Engineered protein effective against Staphylococcus aureus toxin
...ructure as the binding site of the T-cell receptor targeted by SEB. The researchers expressed the engineered protein on the surface of yeast cells (using a process they helped develop, called "yeast display") and generated mutations meant to increase the protein's ability to bind SEB. After several rounds of ...Nanocomposite labeled cancer cells can be targeted and destroyed using lasers
...e such particles into cells and then destroy those targeted cells with a laser. In a presentation at the NSTI Nanotech 2007 Conference, researchers describe work conducted at the NanoBiotechnology Center, Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY and the University of Michig...2007 Joint Assembly in Acapulco -- press conference schedule
... effects that are coming into focus as a result of targeted scientific investigations. In this press conference, panelists will discuss some key results from major field studies conducted in Mexico City and So Paulo, Brazil. Among the highlights, scientists find that the chemistry of emissions from developing...Insignia -- A new way to identify viruses and bacteria
...biological agents. The genome sequencing field has targeted and sequenced the complete genomes of hundreds of bacteria and thousands of viruses over the past decade, which now make it possible to develop programs like Insignia, capable of detecting any given virus or bacterium by its DNA pattern in a sample....Study warns deep-sea mining may pose serious threat to fragile marine ecosystems
..., and some of the governments in the jurisdictions targeted by this industry have a poor record of mining oversight. The prospects for regulation of underwater mining are not good." The study appears in the May 18 issue of the journal Science, and is co-authored by Rodney Fujita, a marine ecologist with U.S...Iowa State scientists demonstrate first use of nanotechnology to enter plant cells
...al biotechnology, creating a powerful new tool for targeted delivery into plant cells. The research, "Mesoporous Silica Nanoparticles Deliver DNA and Chemicals into Plants," is a highlighted article in the May issue of Nature Nanotechnology. The scientists are Kan Wang, professor of agronomy and director o...Pediatric cancer stem cell identified: understanding the origin of ERMS
...ells. The zebrafish is ideally suited for use in targeted chemical genetic approaches to specifically inactivate cancer pathways we have identified in our study. Identifying drugs that inactivate these pathways in theERMS cancer stem cell may have far reaching implications for treatment of patients with thi...Burroughs Wellcome Fund awards $14M to support physician-scientists
...c pathway deregulation provide a novel approach to targeted therapeutics in non-small cell lung carcinoma ...setts Institute of Technology Novel biomarkers and targeted therapies for human lung cancer: translation from a mouse model Joseph C. Wu, M.D., Ph.D. Stanf...Toxoplasmosis infection trick revealed by scientists
...here is potential to develop therapeutics that are targeted at disrupting this mechanism, therefore thwarting infection." Toxoplasma gondii, the parasite that causes toxoplasmosis, is one of the worlds most common parasites. Around a quarter to half of the worlds population is thought to be infected, and ar...UF scientists identify cancer virus' genetic targets
...a researchers have identified specific human genes targeted by a virus believed to cause Kaposis sarcoma, a rare form of cancer associated with AIDS and with organ transplants that causes patches of red or purple tissue to grow under peoples skin. Writing today (May 11) in PLOS Pathogens, the scientists are...Global heartbeat control suggests therapy for beating heart failure
...ardiac energy-sensing machinery. Among the genes targeted by the receptors, the researchers uncovered several that had been linked previously to cardiomyopathies, a finding that Gigure described as "the cherry on the sundae for us." Those direct links to human disease suggest that drugs targeting ERR rece...Anthrax paralyzes immune cells with lethal toxin, UF research shows
...wick are currently looking for additional proteins targeted by anthrax. They hope to develop a diagnostic blood test that detects the bacterium by checking for telltale changes in protein expression. Southwick's team used an unusual approach to tease out the anthrax toxin's effects on cell migration: They a...Einstein's Dr. Vern Schramm elected to the National Academy of Sciences
...n a pivotal phase IIb clinical trial (specifically targeted to study efficacy) at sites in the U.S., eastern and western Europe, and South America. Another transition-state inhibitor developed by Dr. Schramm is now being studied as a possible treatment for autoimmune diseases such as psoriasis, rheumatoid ...New clues for treatment of disease that causes accelerated aging
... cell samples from one of the patients with a drug targeted for progeria, they saw signs that the cells were improving. "Our success in treating these cells, which had unusually high levels of bad lamin A, suggest that progeria treatment may not be as distant as we thought," says senior author Jeffrey Miner, ...Estrogen fluctuation affects epileptic seizures
...at the effects of this hormone in the brain can be targeted to individual synapses, fine-tuning how neurons communicate, and on a much more rapid time scale then previously appreciated. The estrogen regulation of neurotransmitter vesicles points to novel targets for anti-epilepsy therapies....... team, led by the Wellcome Trust Sanger Institute, targeted a gene called Bic/microRNA-155 (or miR-155) in embryonic stem cells which they used to transfer the mutation into mice. Previous research showed that miR-155 was active in cells of the immune system and overactivity was found in lymphoma development....