Antioxidant found in many foods and red wine is potent and selective killer of leukemia cells
...terward. So, there is an intensive search for more targeted therapies for leukemia worldwide, said corresponding author Xiao-Ming Yin, M.D., Ph.D., associate professor of pathology, University of Pittsburgh School of Medicine. Leukemia is not a single disease but a number of related cancers that start in t...JCI table of contents -- April 19, 2007
...ce expressing ovalbumin in the pancreas (the organ targeted by the immune system in type I diabetes) they caused diabetes only if the mice were also transplanted with IgG antibodies that recognize ovalbumin. The antibodies were shown to enable immune cells known as dendritic cells to take up dying pancreatic ...New methods and tools needed to measure exposure to airborne nanomaterials
...ng environments" said Maynard. "This will require targeted research into developing new methodologies and new instruments. But the rapid advancement and commercialization of nanotechnologies are leading to the need for effectiveif not necessarily perfectexposure measurement approaches and devices to be devel...Genes and biomarkers that allow doctors to choose the right therapy for the right patient
... By correlating the responses of these cells to targeted therapeutic drugs, the researchers were able to identify the molecular characteristics of cells that were most sensitive to the drugs. They tested their approach by analyzing responses of the cell line panel to lapatinib, a duel inhibitor of EGFR an...Cetuximab increases survival in advanced colorectal cancer patients, study shows
...This is the first time a single agent biologically targeted therapy has demonstrated a survival advantage in patients with colorectal cancer, and it is also the first time an EGFR-targeting drug has achieved this goal." Conducted by the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) in...Progress toward a targeted therapy for a specific form of leukemia
...ng these mechanisms will enable the development of targeted therapies, which are preferred over chemotherapy. Scientists know that T-ALL arises only when defects occur in several genes simultaneously. So it is not only important to identify the genes that underlie T-ALL, but also to discover which combination...Enhancing chemotherapy's efficacy: New agent has synergistic effect with standard drugs
Integrating the use of drugs targeted to specific cancer proteins into current chemotherapy regimens to improve the efficacy of systemic treatment is an important clinical goal at Fox Chase Cancer Center. Fox Chase research presented during the 97th Annual Meeting of the American Associ...Research team identifies additional genetic risk factors for Crohn's disease
...disease and reveal new causal pathways that can be targeted therapeutically," says Mark Daly, PhD, of the MGH Center for Human Genetics Research and the Broad Institute, co-senior author of the Nature Genetics paper. "The study takes advantage of new knowledge of genetic variation patterns and new technology...Macaque genome analysis will help find human disease genes
...caques, eight from China and eight from India, and targeted five regions of the genome for deeper analysis, sequencing those regions in fine detail in 47 individuals. Macaques show less variation on the X chromosome (one of the two sex chromosomes) than on others, Bustamente's group found. "Evolutionary theor...AACR Annual Meeting showcases significant developments in understanding and targeting cancers
... and therapeutic advances such as personalized and targeted therapies that prolong patients lives, the number ...abolism, stem cell biology, molecular diagnostics, targeted therapies, early detection and the impact of future cancer science on public health will provide a ...India's biotech industry emerging as world innovator, collaborator, competitor
...fy national priorities for public health and use a targeted funding approach to ensure development of products and services that address local health needs. Improve public health infrastructure and/or give incentives to private firms to develop innovative distribution strategies. ...New role for sugars: Research shows connections between sugar modifications in cells and cancer
...ors. These are the same types of proteins that are targeted by a new generation of anti-cancer drugs such as Herceptin (trastuzumab). "These findings may lead to a new class of drug treatments as well as strategies to improve the effectiveness of existing anti-receptor drugs," states Dr. Jim Woodgett, Dire...A 'traffic light' for neurons means 'go' for improving brain research
...or example, this insight will allow development of targeted genetic or pharmaceutical treatments to fix those neurons. Conceivably, direct control of neuronal activity with light could someday become a therapy in itself. A neural traffic light To selectively take control of neurons, the researchers used...UT Metroplex institutions to collaborate on biomedical research
...hin living cells as well as their potential use in targeted cancer therapies. "A pattern-based analysis of neural mediators of working memory deficits in autism" Dr. Greg Allen, assistant professor of psychiatry at UT Southwestern, and Dr. Bart Rypma, associate professor of behavioral and brain science...Leading researchers honored for progress in cancer prevention, detection and treatment
...f cancer and applying these insights to the use of targeted therapies for cancer, will give his lecture "Targeting Genetic Lesions in Cancer: Lessons from EGFR and MET," at noon on Tuesday, April 17, in Hall A of the Los Angeles Convention Center. Thomas W. Kensler, Ph.D., Professor in the Department o...Blood sugar's manufacture limited by building blocks' supply
...ino acid. The researchers found that mice with a targeted deletion of KLF15 display severe hypoglycemia after an overnight fast. They further found evidence that defective amino acid breakdown promotes the development of fasting hypoglycemia in the mutant animals by limiting the availability of a glucose su...Preventing and treating lung cancer -- ESMO explores collaboration to fight cancer on all fronts
...ation (WHO) brief them on the latest approaches to targeted therapies, chemotherapy and, most crucially, the p...How genetic testing can improve the outcome of new targeted therapies for lung cancer (William Gullick, GB, Rolf Stahel, CH, and Giuseppe Giaccone, US) The ...Penn scientists engineer small molecules to probe proteins deep inside cell membrane
...sely related membrane proteins." The researchers targeted two transmembrane proteins called integrins that influence the behavior of platelets, small blood cells important in clotting. One of these, the IIb3 integrin, the most prominent integrin on platelets, is involved in making platelet aggregates, an im......he end of the signaling pathway: the nuclear genes targeted by retrograde signaling. He identified a short motif in the regulatory region of most genes targeted by retrograde signaling and pinpointed ABI4 as the corresponding binding factor. Genes induced by...Overfishing large sharks impacts entire marine ecosystem, shrinks shellfish supply
...ide demand for shark fins and meat." Sharks are targeted in numerous fisheries, and they also are snagged as bycatch in fisheries targeting tunas and swordfish in both U.S. and high seas fisheries. As many as 73 million sharks are killed worldwide each year for the finning trade, and the number is escalat...